This is a competitive renewal of a Jointly Sponsored Neuroscience Training grant that currently funds six slots for pre-thesis Ph.D. students in the Neuroscience Training Program (NSP) at the University of Colorado Denver (UCD). The NSP is an interdisciplinary Ph.D. granting degree started in 1986 that has been funded by an NIH training grant since 1993. The 44 training faculty participating in this grant come from six basic science and six clinical departments. The faculty members have a combined funding of $29 M in direct annual grant dollars, and they have an outstanding record of previous training. Our graduates have a strong record as academicians and scientists. The average number of manuscripts published by our graduates during their tenure at UCD was 3 manuscripts. Among the 35 graduate students as of the Fall of this year 65% are women, 14% underrepresented minorities or disabled and 9% are students from rural colleges and universities in the Rocky Mountain Region. The focus of the NSP is on training outstanding neuroscientists and academicians who will make significant contributions to neurobiology, become leaders in the field and impart these qualities to future generations of neuroscientists. In addition, we aim to foster development of students who approach research in a responsible, professional manner. In the last funding period the Curriculum Committee, working in close collaboration with the Director, refined a curriculum designed to attain these goals. The emphasis is on fostering increasing independence, responsible conduct and critical thinking through courses and laboratory rotations in the first year of instruction so that, in the second year and beyond, we have students who think independently and develop, troubleshoot and communicate effectively the results of their own hypothesis-driven projects.

Public Health Relevance

The purpose of this proposal is to train Neuroscience Ph.D. students to become independent investigators. This is an important goal because the study of the brain and the development of therapies for brain disorders are dependent on a well trained workforce of neuroscientists that will work at basic and translational levels.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD041697-14
Application #
8660065
Study Section
Special Emphasis Panel (ZEY1-VSN (01))
Program Officer
Henken, Deborah B
Project Start
2001-07-03
Project End
2016-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
14
Fiscal Year
2014
Total Cost
$182,337
Indirect Cost
$13,044
Name
University of Colorado Denver
Department
Biology
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Ye, Wenlei; Chang, Rui B; Bushman, Jeremy D et al. (2016) The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction. Proc Natl Acad Sci U S A 113:E229-38
Hughes, Alexandria N; Hixon, Alison M; Josey, Megan (2016) A Schwanncentric View of Axon Arborization in Neuromuscular Junction (NMJ) Formation. J Neurosci 36:9760-2
Lopert, Pamela; Patel, Manisha (2016) Mitochondrial mechanisms of redox cycling agents implicated in Parkinson's disease. J Neural Transm (Vienna) 123:113-23
Meredith, Frances L; Rennie, Katherine J (2016) Channeling your inner ear potassium: K(+) channels in vestibular hair cells. Hear Res 338:40-51
Rowley, Shane; Liang, Li-Ping; Fulton, Ruth et al. (2015) Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy. Neurobiol Dis 75:151-8
Bernard, Paul B; Castano, Anna M; Beitzel, Christy S et al. (2015) Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype. Epilepsy Behav 44:78-85
Barcomb, Kelsey; Goodell, Dayton J; Arnold, Don B et al. (2015) Live imaging of endogenous Ca²⁺/calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activity. J Neurochem 135:666-73
Meredith, Frances L; Rennie, Katherine J (2015) Zonal variations in K+ currents in vestibular crista calyx terminals. J Neurophysiol 113:264-76
Ozbay, Baris N; Losacco, Justin T; Cormack, Robert et al. (2015) Miniaturized fiber-coupled confocal fluorescence microscope with an electrowetting variable focus lens using no moving parts. Opt Lett 40:2553-6
Jones, Heath G; Brown, Andrew D; Koka, Kanthaiah et al. (2015) Sound frequency-invariant neural coding of a frequency-dependent cue to sound source location. J Neurophysiol 114:531-9

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