The Children's Hospital of Philadelphia (CHOP) proposes to continue our NICHD-sponsored Institutional Ruth L. Kirschstein National Research Service Award (NRSA). Our goal is to increase the number and effectiveness of subspecialty pediatricians with a rigorous training in basic, translational and clinical research. We accomplish this by training outstandingpediatric fellows to become successful physician-scientists, addressing questions of fundamental importance to health and disease in children. Candidates for our program are enrolled in our subspecialty fellowship programs who are identified through national searches for the best and the brightest. Each candidate will identify a prospective mentor from a group of 40 mentors: 36 from CHOP (Pediatrics, Pathology, Surgery) and 4 from the University of Pennsylvania (Penn). These CHOP-T32-NRSA mentors were chosen by the following criteria: rigorous science in areas germaine to pediatrics, a record of successful mentoring and collaboration, a strong record of extramural funding, and programmatic balance. Trainee progress is reviewed twice a year by our Core Advisory Committee. Subspecialty trainees are supported for two years to conduct research as outlined in their formal proposals. Trainees in basic and translational research have access to a wide variety of outstanding mentors and educational opportunities, all supported by a wide array of clinical and laboratory research cores. Our T32-NRSA and the companion K12-CHRCDA grant have been highly successful in training physician-scientists who are capable of conducting independent research and who have consistently assumed academic positions. Five of the 11 have obtained advanced (Master's) degrees. This renewal of our CHOP-T32-NRSA will continue the tradition established for the first 5 years of this grant, taking advantage of the tremendous strengths of CHOP as an academic pediatric institution with an outstanding pool of subspecialty fellows, a large number of experienced mentors, and cutting edge research programs. CHOP and Penn provide a very comprehensive, well-supported and resource-intense environment, as well as a proven track record of training academic investigators in basic, translational and clinical research. Relevance: The training of physician-scientists in pediatric subspecialties is critical for advancing the understanding and treatment of childhood diseases, and for providing future leaders in academic pediatrics.

Public Health Relevance

(Seeinstructions): Pediatric medicine's contribution to the health and welfare of future generations requires that physician- scientists continue to be trained in highly academic environments. CHOP is such a place with its long history of achievement in all areas of academic pediatrics. This application proposes to enhance previous training efforts at the postgraduate level, in order to provide a new generation of pediatric physician-scientists with the skills and professional foundation necessary to lead future initiatives in basic and translational research.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
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Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Winer, Karen
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Children's Hospital of Philadelphia
United States
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Weaver, Lehn K; Behrens, Edward M (2014) Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis. Curr Opin Rheumatol 26:562-9
Weaver, Lehn K; Behrens, Edward M (2013) How to use... antinuclear antibodies in paediatric rheumatic diseases. Arch Dis Child Educ Pract Ed 98:64-70
Pierson, Tyler Mark; Torres, Paola A; Zeng, Bei-Jin et al. (2013) Juvenile-onset motor neuron disease caused by novel mutations in ýý-hexosaminidase. Mol Genet Metab 108:65-9
Tuchman, Shamir; Kalkwarf, Heidi J; Zemel, Babette S et al. (2010) Vitamin D deficiency and parathyroid hormone levels following renal transplantation in children. Pediatr Nephrol 25:2509-16
Pierson, Tyler Mark; Bonnemann, Carsten G; Finkel, Richard S et al. (2008) Umbilical cord blood transplantation for juvenile metachromatic leukodystrophy. Ann Neurol 64:583-7
Pierson, T M; Zimmerman, R A; Tennekoon, G I et al. (2008) Mega-corpus callosum, polymicrogyria, and psychomotor retardation: confirmation of a syndromic entity. Neuropediatrics 39:123-7
Donoghue, Aaron J; Nadkarni, Vinay M; Elliott, Michael et al. (2006) Effect of hospital characteristics on outcomes from pediatric cardiopulmonary resuscitation: a report from the national registry of cardiopulmonary resuscitation. Pediatrics 118:995-1001
Matthews, Randolph P; Plumb-Rudewiez, Nicolas; Lorent, Kristin et al. (2005) Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6. Development 132:5295-306
Matthews, Randolph P; Lorent, Kristin; Russo, Pierre et al. (2004) The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development. Dev Biol 274:245-59