Children today are at risk of exposure to multiple environmental hazards - toxic chemicals, social stressors and the hazards of the built environment. Evidence is mounting that exposures in the environment contribute to causation of many common pediatric diseases, and also that they may increase risk for disease in adult life. Yet despite the potential importance of the environment to human health, few pediatricians are trained to study, diagnose, treat or prevent disease of environmental origin, and few academic health centers have programs in environmental pediatrics or research leaders trained to direct such programs. The IOM states that there is national need to expand the scientific workforce in environmental medicine. To train the next generation of physician-researchers and academic leaders in environmental pediatrics, the Mount Sinai School of Medicine seeks support for a 3-year, post-residency interdisciplinary research training program targeted to clinically trained pediatricians. Epidemiological research in environmental pediatrics will be the core training theme. Diseases of principal focus will be neurodevelopmental disorders;diabetes and obesity;and asthma and allergy. We intend to provide our fellows with a robust methodological base and to equip them with a versatile set of tools that they can apply to study a wide range of scientific questions in environmental pediatrics. Selection of fellows will be competitive, and emphasis will be placed on recruitment of underrepresented minorities. In year 1, fellows will receive didactic training in epidemiology, biostatistics, environmental medicine, study design and research methodology. A seminar series in molecular epidemiology and a course on grant writing will complement the core curriculum. In years 2 and 3, emphasis will be placed on a mentored research project. Fellows will gain clinical experience in environmental pediatrics in the Pediatric Environmental Health Specialty Unit. A mentor and 1-2 additional faculty members will guide each fellow. Each fellow's progress will be evaluated semi-annually. Expected outcomes include: authorship of at least 1-2 manuscripts based on original research;authorship of at least 2- 3 posters and/or abstracts for presentation at regional or national meetings;successful completion of an MPH degree focusing on environmental health;development in year 3 of a K08 or R01 grant proposal;and evidence of transition toward independent investigator status. An Executive Faculty Committee and an External Advisory Board have been established to guide the program. This program builds on a fellowship in Pediatric Environmental Health supported at Mount Sinai since 2002 by the Ambulatory Pediatric Association. It links to a Center for Children's Environmental Health and Disease Prevention Research;a Pediatric Environmental Health Specialty Unit;and a recently established Vanguard Center for the National Children's Study.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD049311-04
Application #
7845502
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Raiten, Daniel J
Project Start
2007-05-01
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
4
Fiscal Year
2010
Total Cost
$346,930
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Lee, Alison; Leon Hsu, Hsiao-Hsien; Mathilda Chiu, Yueh-Hsiu et al. (2018) Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex. J Allergy Clin Immunol 141:1880-1886
Rosa, Maria José; Lee, Alison G; Wright, Rosalind J (2018) Evidence establishing a link between prenatal and early-life stress and asthma development. Curr Opin Allergy Clin Immunol 18:148-158
Bambino, Kathryn; Zhang, Chi; Austin, Christine et al. (2018) Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish. Dis Model Mech 11:
Flom, Julie D; Chiu, Yueh-Hsiu Mathilda; Tamayo-Ortiz, Marcela et al. (2018) Subconstructs of the Edinburgh Postpartum Depression Scale in a postpartum sample in Mexico City. J Affect Disord 238:142-146
Lee, Alison G; Chiu, Yueh-Hsiu M; Rosa, Maria J et al. (2017) Association of prenatal and early childhood stress with reduced lung function in 7-year-olds. Ann Allergy Asthma Immunol 119:153-159
Wright, Robert O (2017) Environment, susceptibility windows, development, and child health. Curr Opin Pediatr 29:211-217
Rosa, Maria José; Just, Allan C; Kloog, Itai et al. (2017) Prenatal particulate matter exposure and wheeze in Mexican children: Effect modification by prenatal psychosocial stress. Ann Allergy Asthma Immunol 119:232-237.e1
Walker, R W; Clemente, J C; Peter, I et al. (2017) The prenatal gut microbiome: are we colonized with bacteria in utero? Pediatr Obes 12 Suppl 1:3-17
Rosa, Maria José; Pajak, Ashley; Just, Allan C et al. (2017) Prenatal exposure to PM2.5 and birth weight: A pooled analysis from three North American longitudinal pregnancy cohort studies. Environ Int 107:173-180
Brunst, Kelly J; Rosa, Maria José; Jara, Calvin et al. (2017) Impact of Maternal Lifetime Interpersonal Trauma on Children's Asthma: Mediation Through Maternal Active Asthma During Pregnancy. Psychosom Med 79:91-100

Showing the most recent 10 out of 71 publications