We request funds to continue the interdisciplinary training program in genomics at the University of Washington and affiliated institutions. The program focuses on preparing pre-and postgraduates for a research career in genomics, proteomics and computational biology. Trainees will be engaged in projects that include discovering how a genome encodes the information for gene products to perform complex biological tasks;measuring and analyzing sequence variation;developing technologies to accommodate high throughput experimental assays including next generation sequencing;and generating new computational tools to analyze genomic and proteomic data. As these research challenges demand interdisciplinary approaches and multidisciplinary collaborations, a goal of this program is to attract individuals trained in computer science, statistics, physics, and engineering to biological research. The program also trains cellular and molecular biologists in other disciplines so that they can effectively collaborate at this interdisciplinary interface. Given the wide diversity in educational backgrounds and career goals among our trainees, the program emphasizes highly individualized training programs and interdisciplinary research. A multidisciplinary group of 45 faculty, selected for their involvement in genome and proteome analysis and their strong record of productive collaborative interactions, comprises the training team. Research experience is complemented with a variety of didactic courses and electives. The trainees are also exposed to discussions on ethical research conduct and the ethical, legal, and social implications of genomic research. Breadth of knowledge and program cohesion are achieved through trainee participation in two seminar series that feature genomic research and computational biology, journal clubs, and research reports. In the coming five years, we will continue to expand our program in genomics, proteomics, instrumentation development, computational biology, and statistical genomics. We request funds to train 14 predoctoral and 7 postdoctoral fellows each year so that they emerge with the skills necessary for success in academic and biomedical research of the 21st century made possible by advances in genomics.

Public Health Relevance

Genomics is integral to modern biomedical research and diagnosis. Genome wide studies are used to identify potential genetic causes of disease, and proteomics is often used to identify biomarkers. Our program will train pre and postdoctoral trainees for future biomedical and interdisciplinary research in genomics, proteomics and computational biology.

National Institute of Health (NIH)
National Human Genome Research Institute (NHGRI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Program Officer
Junkins, Heather
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Schools of Medicine
United States
Zip Code
Devine, Emily Beth; Lee, Chia-Ju; Overby, Casey L et al. (2014) Usability evaluation of pharmacogenomics clinical decision support aids and clinical knowledge resources in a computerized provider order entry system: a mixed methods approach. Int J Med Inform 83:473-83
Hope, Elyse A; Dunham, Maitreya J (2014) Ploidy-regulated variation in biofilm-related phenotypes in natural isolates of Saccharomyces cerevisiae. G3 (Bethesda) 4:1773-86
Rival, Pauline; Press, Maximilian O; Bale, Jacob et al. (2014) The conserved PFT1 tandem repeat is crucial for proper flowering in Arabidopsis thaliana. Genetics 198:747-54
Burton, Joshua N; Liachko, Ivan; Dunham, Maitreya J et al. (2014) Species-level deconvolution of metagenome assemblies with Hi-C-based contact probability maps. G3 (Bethesda) 4:1339-46
RaƱola, John Michael; Novembre, John; Lange, Kenneth (2014) Fast spatial ancestry via flexible allele frequency surfaces. Bioinformatics 30:2915-22
Adey, Andrew; Kitzman, Jacob O; Burton, Joshua N et al. (2014) In vitro, long-range sequence information for de novo genome assembly via transposase contiguity. Genome Res 24:2041-9
Hovde, Blake T; Starkenburg, Shawn R; Hunsperger, Heather M et al. (2014) The mitochondrial and chloroplast genomes of the haptophyte Chrysochromulina tobin contain unique repeat structures and gene profiles. BMC Genomics 15:604
Mackelprang, Romel D; Bigham, Abigail W; Celum, Connie et al. (2014) Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans. J Infect Dis 209:1623-7
Kim, Daniel Seung; Kim, Jerry H; Burt, Amber A et al. (2014) Patient genotypes impact survival after surgery for isolated congenital heart disease. Ann Thorac Surg 98:104-10; discussion 110-1
Glukhova, Veronika A; Tomazela, Daniela M; Findlay, Geoffrey D et al. (2013) Rapid assessment of RNAi-mediated protein depletion by selected reaction monitoring mass spectrometry. J Proteome Res 12:3246-54

Showing the most recent 10 out of 118 publications