Duke University Medical Center has been engaged in the training of clinicians and scientists in the area of cardiovascular diseases for over 50 years. The philosophy has been to integrate training and research by creating an environment that facilitates the natural linkages among programs and departments throughout the University. By any measure, the program has succeeded in training a generation of outstanding investigators who are now prominent teachers and leaders in academic medicine. Much of this success can be attributed to 34 years of funding of the Cardiovascular Training Program Grant. Our goal is to maintain this history of productivity by creating an environment that will ensure that Duke will continue to contribute to the development of young investigators capable of pursuing successful research careers in cardiovascular fields. Since the last competing renewal, the PI has implemented a number of substantial changes to our program in an effort to significantly enhance the educational and research experience of our trainees. Some examples of changes that have been made to our program include: 1) Didactic course work during research fellowship that can lead to a Masters Degree from the School of Medicine, 2) Weekly seminar series on grant writing and mentoring in the summer of each year, 3) Requirement that all trainees apply for extramural funding for a Postdoctoral Research Grant in the second year of Cardiology Fellowship, 4) Biannual written evaluations of mentors by trainees, 5) Biannual written evaluations of trainees by mentors, 6) Year-end Research Symposium for fellows, with awards for the best abstract presentation, 7) Regular basic science research conferences given by program faculty to all cardiology trainees, 8) Creation of a two- month basic science elective during the first year of the clinical fellowship program for all fellows as an introduction to the basic sciences, and 9) New format to our Monthly Research Conference that integrates clinical and basic research on a thematic basis, and which provides a forum where trainees learn how to translate findings freely between the basic and clinical spheres. The goal of this program is to continue our training of talented Physician-Scientists by creating an environment that will ensure the development of our young trainees into highly successful and innovative independent investigators.

Public Health Relevance

The training of future academic scientists in cardiovascular research recognizes the need to accelerate translation of findings from discovery sciences into clinically useful therapies and strategies. This training program will provide a high-quality mentored research training experience for those future researchers who collectively will make the discoveries of scientists working in basic laboratories available to patients in the form of improved medical care.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007101-38
Application #
8393465
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1975-07-01
Project End
2016-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
38
Fiscal Year
2013
Total Cost
$578,424
Indirect Cost
$40,180
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Kahsai, Alem W; Wisler, James W; Lee, Jungmin et al. (2016) Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nat Chem Biol 12:709-16
Stiber, Jonathan A; Wu, Jiao-Hui; Zhang, Lisheng et al. (2016) The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol 36:984-93
Hunter, Wynn G; Kelly, Jacob P; McGarrah 3rd, Robert W et al. (2016) Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure. J Am Heart Assoc 5:
Mokalled, Mayssa H; Patra, Chinmoy; Dickson, Amy L et al. (2016) Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. Science 354:630-634
Hanna, Jennifer M; Keenan, Jeffrey E; Wang, Hanghang et al. (2016) Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest. J Thorac Cardiovasc Surg 151:376-82
Samad, Zainab; Vora, Amit N; Dunning, Allison et al. (2016) Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction. Eur Heart J 37:2276-86
White, Phillip J; Lapworth, Amanda L; An, Jie et al. (2016) Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Mol Metab 5:538-51
Ahmad, Tariq; Kelly, Jacob P; McGarrah, Robert W et al. (2016) Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support. J Am Coll Cardiol 67:291-9
McGarrah, Robert W (2016) Refocusing the AIM on HDL in the metabolic syndrome. Atherosclerosis 251:531-3
Hunter, Wynn G; Kelly, Jacob P; McGarrah 3rd, Robert W et al. (2016) Metabolic Dysfunction in Heart Failure: Diagnostic, Prognostic, and Pathophysiologic Insights From Metabolomic Profiling. Curr Heart Fail Rep 13:119-31

Showing the most recent 10 out of 205 publications