The Cardiovasology Post-doctoral Training Program at Mayo Clinic, in this renewal, requests continuation of support for years 36 to 40. Through four decades of mentored career development, the Program has realized the mission of preparing physicians and scientists for independent research careers in cardiovascular medicine and biology. Trainees have acquired rigorous scientific proficiency, excelled in productivity, established track- records in research support, and secured academic placements contributing to the nation's diverse workforce. Accomplishments have included strong recruitment and retention, interactive mentoring with outstanding NIH- funded faculty, robust infrastructure and cooperative environment ensuring launch of competitive careers. The renewal spans science-education-practice intersections to best equip next generation investigators. Mapped to draw from highest educational standards and cutting-edge technological platforms, the Program is customized to match the background and career path of each trainee, while widening interests and capabilities in pursuit of evolving scientific advances. Heart failure - with focus on translation from the bench to the bedside to populations - is the central theme, reflecting national morbidity and mortality trends. The Program actuates the NHLBI Strategic Plan by implementing training for the better understanding of molecular and clinical mechanisms of heart failure aimed at improved prevention, diagnosis, and treatment of individuals and the public-at-large. Leveraging major initiatives at Mayo Clinic, including the NIH Center for Translational Science Activities, Department of Health and Human Services Southeast Minnesota Beacon Program, NHLBI Heart Failure Clinical Research Network, NIH Pharmacogenomics Research Network, NHLBI Cardiovascular Cell Therapy Research Network, and Minnesota Partnership for Biotechnology and Medical Genomics, the Program assembles collaborative and complementary teams of mentors across the discovery-translation- application continuum interconnected with local/regional/national centers of excellence. Committed to NHLBI programmatic emphases, the renewal integrates multidisciplinary training to achieve competencies in evolving areas of scientific need. The renewal capitalizes on degree-granting programs; community-based heart failure registries and biobanks; enabling biotechnology platforms; and rolled-out diagnostics/therapeutics pipelines. Aligned with Mayo Clinic Strategic Priorities of Individualized Medicine, Regenerative Medicine, and Science of Health Care Delivery, offerings have been enriched to include curricula in personalized medicine and Pharmacogenomics; regenerative medicine; systems biology and bioinformatics; molecular imaging; genetic epidemiology; comparative effectiveness; and health disparities research. A fellow-to-faculty career development program is in place to foster faculty transition, and a minority recruitment and responsible conduct of research plans are implemented to ensure consistent success. The renewal underscores the vision of the Cardiovasology Program to provide most advanced training at the vanguard of cardiovascular research.

Public Health Relevance

Project Health Relevance Statement Cardiovascular disease is the leading cause of global mortality, accounting for 1 of every 3 deaths in the United States. The 'Cardiovasology' Training Program offers post-graduate training to best equip next generations of physicians and scientists committed to cardiovascular research careers in advancing prevention, diagnosis, and treatment of heart failure in patients and populations.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007111-38
Application #
8877578
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
1975-07-01
Project End
2016-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
38
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Reddy, Yogesh N V; Olson, Thomas P; Obokata, Masaru et al. (2018) Hemodynamic Correlates and Diagnostic Role of Cardiopulmonary Exercise Testing in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail 6:665-675
Khorramirouz, Reza; Go, Jason L; Noble, Christopher et al. (2018) A novel surgical technique for a rat subcutaneous implantation of a tissue engineered scaffold. Acta Histochem 120:282-291
Reddy, Yogesh N V; Obokata, Masaru; Gersh, Bernard J et al. (2018) High Prevalence of Occult Heart Failure With Preserved Ejection Fraction Among Patients With Atrial Fibrillation and Dyspnea. Circulation 137:534-535
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Tefft, Brandon J; Uthamaraj, Susheil; Harbuzariu, Adriana et al. (2018) Nanoparticle-Mediated Cell Capture Enables Rapid Endothelialization of a Novel Bare Metal Stent. Tissue Eng Part A 24:1157-1166
Choe, Joshua A; Jana, Soumen; Tefft, Brandon J et al. (2018) Biomaterial characterization of off-the-shelf decellularized porcine pericardial tissue for use in prosthetic valvular applications. J Tissue Eng Regen Med 12:1608-1620
Bell, Elizabeth J; Decker, Paul A; Tsai, Michael Y et al. (2018) Hepatocyte growth factor is associated with progression of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 272:162-167
Reddy, Yogesh N V; El Sabbagh, Abdallah; Packer, Douglas et al. (2018) Evaluation of shortness of breath after atrial fibrillation ablation-Is there a stiff left atrium? Heart Rhythm 15:930-935
Egbe, Alexander C; Reddy, Yogesh N V; Khan, Arooj R et al. (2018) Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment. Int J Cardiol 271:312-316
Reddy, Yogesh N V; Carter, Rickey E; Obokata, Masaru et al. (2018) A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction. Circulation 138:861-870

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