The breadth of interdisciplinary research teams is expanding dramatically. At the intersection of environment and health, in particular, teams increasingly need strong grounding in basic biology and genetics while at the same time need increasingly sophisticated analyses of disease models. Only then will they be prepared to study the interaction of susceptibility genes with environmental exposures. For that reason we have adopted the approach that the modern trainee cannot be expected to do it all;rather, to succeed he or she will need to be prepared with the strongest possible disciplinary foundation together with the tools needed to work effectively with others outside their own discipline. From a large and talented pool of applicants, we select outstanding BS and DVM trainees who seek the PhD or ScD degree, and outstanding PhD, MD, and DVM trainees who make a 3-year commitment to postdoctoral training in interdisciplinary pulmonary sciences. Trainees with backgrounds in biology, medicine, engineering, and physics work side-by-side on problems at the intersection of pulmonary sciences and environmental exposures. These trainees benefit from working with each other, working with trainees not supported by this T32, and working with a well-funded interdisciplinary faculty. This faculty addresses three main problems: air pollution, lung infection, and asthma. The theme of pulmonary inflammation spans these foci. Another theme is a strong emphasis on engineering and physical sciences. Bridging the gap between the life sciences and the physical / engineering sciences has been a longstanding goal of our program. These themes foster exceptional levels of collaboration among a faculty with unusually diverse expertise and interests. They form the faculty into a cohesive interdisciplinary team elucidating basic mechanisms of lung disease. Our Program offers access to excellent facilities and unique nanotechnologies, and is designed so that trainees will: 1) master modern technologies of cell and molecular biology as well as integrative physiology;2) learn the relative strengths and weaknesses of different approaches, 3) design experiments effectively and interpret data critically, 4) adapt well to change, and 5) build successful careers as responsible members of the scientific community. In the past 34 years of our T32 we have never had an unfilled slot. In the past 10 years of our T32, 6 of our trainees were underrepresented minorities and 27 have completed training. 25 are currently working in science, including 7 in industry and 18 in academia at the rank of assistant professor or higher.

Public Health Relevance

Our training program addresses three main problems: air pollution, lung infection, and asthma. The theme of pulmonary inflammation certainly spans these problems, as does a strong interdisciplinary emphasis on bridging the gap between the biological sciences and the physical sciences. These bridging themes form our faculty into a cohesive interdisciplinary training program elucidating basic mechanisms of lung disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007118-36
Application #
8017601
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Rothgeb, Ann E
Project Start
1975-07-01
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
36
Fiscal Year
2011
Total Cost
$592,698
Indirect Cost
Name
Harvard University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Joachim, Rose; Suber, Freeman; Kobzik, Lester (2017) Characterising Pre-pubertal Resistance to Death from Endotoxemia. Sci Rep 7:16541
Mathews, Joel A; Krishnamoorthy, Nandini; Kasahara, David Itiro et al. (2017) IL-33 Drives Augmented Responses to Ozone in Obese Mice. Environ Health Perspect 125:246-253
Wagner, Peter J; Park, Hae-Ryung; Wang, Zhaoxi et al. (2017) In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children. Environ Health Perspect 125:721-729
Watson-Wright, Christa; Singh, Dilpreet; Demokritou, Philip (2017) Toxicological Implications of Released Particulate Matter during Thermal Decomposition of Nano-Enabled Thermoplastics. NanoImpact 5:29-40
Lasky-Su, Jessica; Dahlin, Amber; Litonjua, Augusto A et al. (2017) Metabolome alterations in severe critical illness and vitamin D status. Crit Care 21:193
Nwanaji-Enwerem, Jamaji C; Colicino, Elena; Dai, Lingzhen et al. (2017) Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age. Environ Sci Technol 51:8185-8195
Pirela, Sandra V; Lu, Xiaoyan; Miousse, Isabelle et al. (2016) Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: A case study of toxicological implications from nanomaterials released during consumer use. NanoImpact 1:1-8
Notbohm, Jacob; Banerjee, Shiladitya; Utuje, Kazage J C et al. (2016) Cellular Contraction and Polarization Drive Collective Cellular Motion. Biophys J 110:2729-38
Lu, Xiaoyan; Miousse, Isabelle R; Pirela, Sandra V et al. (2016) In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles. Nanotoxicology 10:629-39
Brand, Jeffrey D; Mathews, Joel A; Kasahara, David I et al. (2016) Regulation of IL-17A expression in mice following subacute ozone exposure. J Immunotoxicol 13:428-38

Showing the most recent 10 out of 127 publications