The primary objective of this proposal is to continue our longstanding cardiopulmonary research training efforts at the University of Colorado Denver, Anschutz Medical Center Campus. This program trains individuals with doctoral degrees in either biological or medical sciences for successful academic careers in cardiopulmonary research and teaching. A multidisciplinary approach to both mentoring and research training is emphasizing the integration of studies at the molecular, cellular, tissue organ, and physiological (whole animals or human subjects) levels to permit rapid bench-to-bedside translation of the work performed. We have expanded the focus of the training program in this submission to include access to expertise in Bioengineering, Regenerative Medicine, Genomics, and Child-Maternal Health. This expanded focus will enable us to involve outstanding programs and investigators whose work is directly related to Cardiopulmonary Biology. Of the many training grants at the University of Colorado, this is the only one specifically dedicated to pulmonary vascular biology. Our continuing and long-term goal is that after 3 years of training the program's fellows will have acquired the professional skills to be competitive and obtain their own extramural funds. Our records show that we have achieved this benchmark. Therefore, our specific objectives are: 1) To provide trainee fellows with an intensive research experience in cardiovascular-pulmonary research with a focus on the pathophysiological aspects of chronic pulmonary vascular disease and right heart failure, by pairing them with mentors who are rigorously selected based on their qualifications and scientific area of expertise and placing them in a collaborative, stimulating environment, 2) To enhance the scientific knowledge and critical thinking abilities of the participating trainees by requiring a series of workshops/lecturs on hypothesis formulation, experimental design, reporting and presentation of scientific information, grant proposal preparation and hands on experience in innovative molecular and cellular physiological approaches to cardiovascular-pulmonary research, 3) To enhance multidisciplinary, collaborative approaches to research by requiring co-mentors, and strong interaction with an Internal Advisory Committee with oversight by Executive and External Advisory Committees, 4) To ensure that Fellows acquire and learn the necessary information to conduct and report research in an ethical manner, and 5) To provide the trainees with the information they need regarding a career in academic medicine and research by exposing them to available funding mechanisms for physician/basic scientists such as K-series awards and other mentored clinician scientist awards. The increasing national and international interest in pulmonary vascular biology, the expanded nature of our program, and the excellent track record of training individuals from all backgrounds, including underrepresented minorities, support our request for 6 postdoctoral trainees each year.

Public Health Relevance

A large number of human diseases can affect the structure and function of blood vessels in the lung. In fact, when diseases are complicated by increases in pressure in the lung blood vessels (lung vascular disease), significant increases in morbidity and mortality are observed. This program is directed at training individuals to better understand the causes of lung vascular disease with the long-tem goal that these investigators will develop new therapies to decrease or ameliorate the health burden of lung vascular problems.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007171-36
Application #
8414354
Study Section
Special Emphasis Panel (ZHL1-CSR-F (O1))
Program Officer
Colombini-Hatch, Sandra
Project Start
1976-07-01
Project End
2018-06-30
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
36
Fiscal Year
2013
Total Cost
$390,836
Indirect Cost
$27,884
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Schäfer, Michal; Myers, Cynthia; Brown, R Dale et al. (2016) Pulmonary Arterial Stiffness: Toward a New Paradigm in Pulmonary Arterial Hypertension Pathophysiology and Assessment. Curr Hypertens Rep 18:4
Keller, Amy C; Knaub, Leslie A; McClatchey, P Mason et al. (2016) Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxid Med Cell Longev 2016:8524267
McClatchey, P Mason; Keller, Amy C; Bouchard, Ron et al. (2016) Fully automated software for quantitative measurements of mitochondrial morphology. Mitochondrion 26:58-71
Reid, Brian G; Stratton, Matthew S; Bowers, Samantha et al. (2016) Discovery of novel small molecule inhibitors of cardiac hypertrophy using high throughput, high content imaging. J Mol Cell Cardiol 97:106-13
Li, Min; Riddle, Suzette; Zhang, Hui et al. (2016) Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1. Circulation 134:1105-1121
Keller, Amy C; Knaub, Leslie A; Miller, Matthew W et al. (2015) Saxagliptin restores vascular mitochondrial exercise response in the Goto-Kakizaki rat. J Cardiovasc Pharmacol 65:137-47
Lemon, Douglas D; Harrison, Brooke C; Horn, Todd R et al. (2015) Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa HDAC axis in striated muscle. FEBS Lett 589:1080-8
Ferguson, Bradley S; McKinsey, Timothy A (2015) Non-sirtuin histone deacetylases in the control of cardiac aging. J Mol Cell Cardiol 83:14-20
Ostriker, Allison; Horita, Henrick N; Poczobutt, Joanna et al. (2014) Vascular smooth muscle cell-derived transforming growth factor-β promotes maturation of activated, neointima lesion-like macrophages. Arterioscler Thromb Vasc Biol 34:877-86
El Kasmi, Karim C; Pugliese, Steven C; Riddle, Suzette R et al. (2014) Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol 193:597-609

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