The goal of this program is to prepare scientists for research careers in the cardiovascular area, through interdisciplinary training at the predoctoral and postdoctoral levels. The University of Arizona provides a highly suitable environment for training in the cardiovascular area. It is noted for its well-established system of interdisciplinary graduate programs and for its tradition of collaborations across departmental boundaries. The environment has recently been enhanced with the formation of Cardiovascular Research and Diabetes Research Centers with extensive new research space. Thirty-three training faculty from thirteen departments, all with active, well-funded, collaborative research programs, provide strength in three broad areas of cardiovascular research: 1) cardiovascular development;2) tissue homeostasis, and 3) cardiovascular disease. Emphasis on integrating research at molecular, cellular and systems levels is a particular strength of the program. The broad range of in vitro and in vivo techniques available in faculty laboratories, together with University-supported core facilities (transgenic animal, proteomics, microarray, DMA core, chemical synthesis, histology, microscopy, FACs), provides a rich environment for cardiovascular research. The training program is adaptable to the specific needs and interests of the trainees, while ensuring that they gain a broad appreciation for cardiovascular research. Predoctoral training in the first year is built around coursework in molecular, cellular and systems biology, augmented with laboratory rotations, a course in scientific writing and ethics, and seminars to provide a broad background in physiology as well as exposure to various research laboratories, experimental approaches, and practical aspects of careers in science. In subsequent years, trainees focus on their research area through specialty coursework, colloquia, tutorials, and their dissertation research. Attendance at national and international meetings, a """"""""meet the speaker"""""""" program and the interdisciplinary environment of the graduate programs provide trainees with ample opportunities to interact with researchers using different approaches. Postdoctoral training is focused on learning state-of-the-art techniques in the area selected for study, developing greater sophistication in application of the experimental method, and developing and testing hypotheses. Trainees of the program are well prepared for careers in cardiovascular research. Of the 151 trainees appointed since the program's inception, 85% remain in research related positions;a similar track record pertains to the 66 trainees appointed in the last ten years.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007249-34
Application #
7826821
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Carlson, Drew E
Project Start
1977-07-01
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
34
Fiscal Year
2010
Total Cost
$303,154
Indirect Cost
Name
University of Arizona
Department
Physiology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Chen, Xiaochuan; Kelly, Amy C; Yates, Dustin T et al. (2017) Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine. J Endocrinol 232:285-295
Rosado-Toro, Jose A; Abidov, Aiden; Altbach, Maria I et al. (2017) Segmentation of the right ventricle in four chamber cine cardiac MR images using polar dynamic programming. Comput Med Imaging Graph 62:15-25
Jacobsen, Nicole L; Pontifex, Tasha K; Li, Hanjun et al. (2017) Regulation of Cx37 channel and growth-suppressive properties by phosphorylation. J Cell Sci 130:3308-3321
Tillotson, Joseph; Kedzior, Magdalena; Guimarães, Larissa et al. (2017) ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett 27:4082-4085
Severance, Alyscia Cory; Sandoval, Philip J; Wright, Stephen H (2017) Correlation between Apparent Substrate Affinity and OCT2 Transport Turnover. J Pharmacol Exp Ther 362:405-412
McConnell, Mark; Tal Grinspan, Lauren; Williams, Michael R et al. (2017) Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap. Biochemistry 56:3403-3413
Martínez-Guerrero, L J; Evans, K K; Dantzler, W H et al. (2016) The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules. Am J Physiol Renal Physiol 310:F57-67
Rosado-Toro, Jose A; Altbach, Maria I; Rodriguez, Jeffrey J (2016) Dynamic Programming Using Polar Variance for Image Segmentation. IEEE Trans Image Process :
Williams, Michael R; Lehman, Sarah J; Tardiff, Jil C et al. (2016) Atomic resolution probe for allostery in the regulatory thin filament. Proc Natl Acad Sci U S A 113:3257-62
Moore-Dotson, Johnnie M; Beckman, Jamie J; Mazade, Reece E et al. (2016) Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling. Invest Ophthalmol Vis Sci 57:1418-30

Showing the most recent 10 out of 110 publications