The Washington University Program in Principles of Pulmonary Research provides multidisciplinary training for predoctoral and postdoctoral scholars committed to a career in respiratory research. The postdoctoral portion of the Program enables MD and MD/PhD physicians who are training in pulmonary and critical care medicine to learn state-of-the-art scientific research in concert with PhD trainees from a basic science background. The predoctoral portion of the Program engages students in the MD/PhD and PhD graduate division to work in close connection with the same respiratory research curriculum. The proposal remains at seven postdoctoral and five predoctoral trainees with 2-3 years of support before transitioning to additional career development awards.
The aim of the Program is to promote the career development of trainees so they will enter academic pulmonary medicine with the skills needed to study problems relevant to respiratory diseases. The Program is closely monitored through a Director and four Committees (Internal Advisory, External Advisory, Review, and Diversity Recruitment) and relies on 25 senior mentors, 11 junior mentors, and 15 support faculty distributed into a coordinated set of three interdisciplinary research tracks, including two basic-translational tracks (Immunology-Host Defense and Epithelial Cell-Matrix Biology) and one clinical-translational track (for further application to human disease). The basic tracks are designed to correspond to the major themes of the pulmonary research program and to coincide with the graduate training program, and the clinical track is aimed at extending these fields to human subject research and the CTSA curriculum. This program structure allows for a broad-based faculty from 13 departments to coordinate and focus research activities and trainee supervision in a collaborative and synergistic process. For all trainee activities within this structure, there is also a carefully constructed mentoring process that includes benchmarks for individual trainee presentation, publication, and grant application. To achieve these goals, all predoctoral and postdoctoral trainees engage in the same research review process that is home-based around a joint Research and Development Conference. This conference is the hub for input from an overall Program Review Committee (that includes the Program Director and his advisors) and a project-specific Advisory Committee (that includes the trainee's mentors, co- mentors, and collaborators). Trainees also receive input via individual lab and group meetings as well as additional research conferences that are set up to coordinate with the research themes of the Program. The research-intense experience is supplemented through graduate coursework to build general skills and specific knowledge of a research field. Together, these mechanisms serve to ensure high-level trainee experiences and performance in previous and present cycles of this longstanding and highly successful Program.

Public Health Relevance

Respiratory disease represents a major health care problem. Indeed, chronic lower respiratory (lung) disease is the third leading cause of death in the U.S. population. The purpose of our pulmonary research training program is to develop new leaders and innovators to drive research and development in the field of lung disease and thereby help solve this problem.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
Zip Code
Monaco, Cynthia L; Gootenberg, David B; Zhao, Guoyan et al. (2016) Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host Microbe 19:311-22
Slatore, Christopher G; Kulkarni, Hrishikesh S; Corn, Judy et al. (2016) Improving Health Literacy. The New American Thoracic Society Guidelines for Patient Education Materials. Ann Am Thorac Soc 13:1208-11
Le Borgne, Marie; Raju, Saravanan; Zinselmeyer, Bernd H et al. (2016) Real-Time Analysis of Calcium Signals during the Early Phase of T Cell Activation Using a Genetically Encoded Calcium Biosensor. J Immunol 196:1471-9
Lu, Qun; Yokoyama, Christine C; Williams, Jesse W et al. (2016) Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host Microbe 19:102-13
Bosanquet, James P; Witt, Chad A; Bemiss, Bradford C et al. (2015) The impact of pre-transplant allosensitization on outcomes after lung transplantation. J Heart Lung Transplant 34:1415-22
Wu, Kangyun; Byers, Derek E; Jin, Xiaohua et al. (2015) TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med 212:681-97
Norman, Jason M; Handley, Scott A; Baldridge, Megan T et al. (2015) Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell 160:447-60
Guzy, Robert D; Stoilov, Ivan; Elton, Timothy J et al. (2015) Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin. Am J Respir Cell Mol Biol 52:116-28
Sheshadri, Ajay; Rodriguez, Alfonso; Chen, Ryan et al. (2015) Effect of Reducing Field of View on Multidetector Quantitative Computed Tomography Parameters of Airway Wall Thickness in Asthma. J Comput Assist Tomogr 39:584-90
Kulkarni, Hrishikesh S; Bemiss, Bradford C; Hachem, Ramsey R (2015) Antibody-mediated Rejection in Lung Transplantation. Curr Transplant Rep 2:316-323

Showing the most recent 10 out of 109 publications