The purpose of this training program is to select talented and committed young investigators and to prepare them for careers in cardiovascular research. This program has been in place at this institution since 1978. A substantial number of our previous trainees remain active in research and have made notable contributions to cardiovascular investigation. We are proud of this tradition, and the current proposal preserves many features of our previously successful program. The only important organizational change since the last competitive renewal in 1997 is the replacement of the Program Director, R. Sanders Williams, M.D., by L. David Hillis, M.D. The 3 Associate Directors (Drs. Eric Olson, Masashi Yanagisawa, and James Stull) remain in place, as do many of the Participating Faculty. We request funds for 8 predoctoral and 16 postdoctoral positions annually (unchanged from previously). Our faculty is multidisciplinary: 55 individuals who represent 10 academic departments and 8 Graduate School programs. The faculty are linked by a common interest in important problems of cardiovascular biology and medicine as well as by an interlocking network of collaborative activities, including several research centers and PPG grants. Cardiovascular research training is offered in 4 general areas: (1) Developmental and Molecular Biology, (2) Vascular Biology, (3) Physiology and Signaling, and (4) Clinical Sciences. This Program gives particular attention to (a) the integration of molecular genetics and biological chemistry with physiological investigations in a broad range of model organisms and human subjects, (b) to issues of scientific integrity and ethics, and (c) to increasing the participation of females and underrepresented minority groups in the training program, both as participants and as faculty.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007360-35
Application #
8311690
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1978-07-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
35
Fiscal Year
2012
Total Cost
$415,517
Indirect Cost
$69,751
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Michael, Tesfaldet T; Karmpaliotis, Dimitri; Brilakis, Emmanouil S et al. (2015) Temporal trends of fluoroscopy time and contrast utilization in coronary chronic total occlusion revascularization: insights from a multicenter united states registry. Catheter Cardiovasc Interv 85:393-9
Lo, Nathan; Michael, Tesfaldet T; Moin, Danyaal et al. (2014) Periprocedural myocardial injury in chronic total occlusion percutaneous interventions: a systematic cardiac biomarker evaluation study. JACC Cardiovasc Interv 7:47-54
Grundy, Scott M; Neeland, Ian J; Turer, Aslan T et al. (2014) Ethnic and gender susceptibility to metabolic risk. Metab Syndr Relat Disord 12:110-6
Patel, Vishal G; Michael, Tesfaldet T; Mogabgab, Owen et al. (2014) Clinical, angiographic, and procedural predictors of periprocedural complications during chronic total occlusion percutaneous coronary intervention. J Invasive Cardiol 26:100-5
Jeroudi, Omar M; Alomar, Mohammed E; Michael, Tesfaldet T et al. (2014) Prevalence and management of coronary chronic total occlusions in a tertiary Veterans Affairs hospital. Catheter Cardiovasc Interv 84:637-43
Wang, Zhao V; Deng, Yingfeng; Gao, Ningguo et al. (2014) Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. Cell 156:1179-92
Mogabgab, Owen; Patel, Vishal G; Michael, Tesfaldet T et al. (2014) Impact of contrast agent viscosity on coronary balloon deflation times: bench testing results. J Interv Cardiol 27:177-81
Schlader, Zachary J; Crandall, Craig G (2014) Normothermic central hypovolemia tolerance reflects hyperthermic tolerance. Clin Auton Res 24:119-26
Garg, Ankit; O'Rourke, Jason; Long, Chengzu et al. (2014) KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy. J Clin Invest 124:3529-39
Liu, Ning; Nelson, Benjamin R; Bezprozvannaya, Svetlana et al. (2014) Requirement of MEF2A, C, and D for skeletal muscle regeneration. Proc Natl Acad Sci U S A 111:4109-14

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