Channing Laboratory Training Program in the Clinical Epidemiology of Lung Diseases This training program is a competing continuation of a program funded by National Research Service Award T32 HL007427. The program, which has operated continuously for the past 30 years, focuses on chronic respiratory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD), which are major public health problems. Asthma and COPD are linked with early childhood factors, including gender, diet, allergen exposure, and cigarette smoke exposure, as well as with genetic susceptibility;these factors influence disease expression throughout life. Based on our current knowledge of complex traits, there is a critical need for individuals trained in the application of epidemiologic and genetic methods to perform quantitative research in respiratory biology. This program is instrumental in meeting this need, successfully training independent research investigators who go on to lead their own research programs across the U.S. and Canada. The program provides research training in 3 areas: biostatistics, epidemiologic risk factors, and genetics/genomics. Six post-doctoral and two pre-doctoral training positions are requested in this proposal. The trainees interact with a pool of 37 faculty members in the 3 interrelated research areas. Each trainee will have the opportunity to become involved in the design, execution, and analysis of ongoing federally and non-federally funded research projects as well as develop an independent career path. Trainees'research is conducted at the Channing Laboratory, a research division of the Department of Medicine at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS). Pre-doctoral trainees work toward a Ph.D. in biostatistics or an Sc.D. in epidemiology. Post-doctoral trainees undertake didactic classroom work leading to a master of science (Sc.M.) in epidemiology, or a master of public health (M.P.H.) degree, with a concentration in quantitative methods at the Harvard School of Public Health (HSPH). After completing our program, trainees will be eligible to assume faculty positions in biostatistics or respiratory epidemiology. Trainees benefit from a close relationship with the Departments of Environmental Health and Biostatistics at HSPH and the Division of Pulmonary and Critical Care Medicine at the Brigham and Women's Hospital. In the past 15 years, we have had 98% retention of T32 trainees in faculty or other research positions.

Public Health Relevance

Channing Laboratory Training Program in the Clinical Epidemiology of Lung Diseases Providing appropriate training in respiratory epidemiology will be essential for the next generation of leaders in respiratory population-based research. This T32 program will build on a successful track record of training with both formal didactic education and mentored research experiences. The medical researchers trained in this program have made, and will continue to make, important contributions to our understanding of asthma and COPD that will lead to more effective treatment for these diseases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Tigno, Xenia
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Busch, Robert; Hobbs, Brian D; Zhou, Jin et al. (2017) Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. Am J Respir Cell Mol Biol 57:35-46
McGeachie, Michael J; Davis, Joshua S; Kho, Alvin T et al. (2017) Asthma remission: Predicting future airways responsiveness using an miRNA network. J Allergy Clin Immunol 140:598-600.e8
Trivedi, Michelle K; Sharma, Sunita; Rifas-Shiman, Sheryl L et al. (2017) Folic Acid in Pregnancy and Childhood Asthma: A US Cohort. Clin Pediatr (Phila) :9922817729482
Hobbs, Brian D; de Jong, Kim; Lamontagne, Maxime et al. (2017) Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet 49:426-432
Mirzakhani, Hooman; O'Connor, George; Bacharier, Leonard B et al. (2017) Asthma control status in pregnancy, body mass index, and maternal vitamin D levels. J Allergy Clin Immunol 140:1453-1456.e7
Boueiz, Adel; Lutz, Sharon M; Cho, Michael H et al. (2017) Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med 195:757-771
Hayden, Lystra P; Cho, Michael H; McDonald, Merry-Lynn N et al. (2017) Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis. Am J Respir Cell Mol Biol 56:20-28
Croteau-Chonka, Damien C; Qiu, Weiliang; Martinez, Fernando D et al. (2017) Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control. Am J Respir Crit Care Med 195:179-188
Qiao, Dandi; Lange, Christoph; Laird, Nan M et al. (2017) Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol 41:309-319
McGeachie, M J; Yates, K P; Zhou, X et al. (2016) Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med 374:1842-1852

Showing the most recent 10 out of 222 publications