Channing Laboratory Training Program in the Clinical Epidemiology of Lung Diseases This training program is a competing continuation of a program funded by National Research Service Award T32 HL007427. The program, which has operated continuously for the past 30 years, focuses on chronic respiratory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD), which are major public health problems. Asthma and COPD are linked with early childhood factors, including gender, diet, allergen exposure, and cigarette smoke exposure, as well as with genetic susceptibility;these factors influence disease expression throughout life. Based on our current knowledge of complex traits, there is a critical need for individuals trained in the application of epidemiologic and genetic methods to perform quantitative research in respiratory biology. This program is instrumental in meeting this need, successfully training independent research investigators who go on to lead their own research programs across the U.S. and Canada. The program provides research training in 3 areas: biostatistics, epidemiologic risk factors, and genetics/genomics. Six post-doctoral and two pre-doctoral training positions are requested in this proposal. The trainees interact with a pool of 37 faculty members in the 3 interrelated research areas. Each trainee will have the opportunity to become involved in the design, execution, and analysis of ongoing federally and non-federally funded research projects as well as develop an independent career path. Trainees'research is conducted at the Channing Laboratory, a research division of the Department of Medicine at Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS). Pre-doctoral trainees work toward a Ph.D. in biostatistics or an Sc.D. in epidemiology. Post-doctoral trainees undertake didactic classroom work leading to a master of science (Sc.M.) in epidemiology, or a master of public health (M.P.H.) degree, with a concentration in quantitative methods at the Harvard School of Public Health (HSPH). After completing our program, trainees will be eligible to assume faculty positions in biostatistics or respiratory epidemiology. Trainees benefit from a close relationship with the Departments of Environmental Health and Biostatistics at HSPH and the Division of Pulmonary and Critical Care Medicine at the Brigham and Women's Hospital. In the past 15 years, we have had 98% retention of T32 trainees in faculty or other research positions.

Public Health Relevance

Channing Laboratory Training Program in the Clinical Epidemiology of Lung Diseases Providing appropriate training in respiratory epidemiology will be essential for the next generation of leaders in respiratory population-based research. This T32 program will build on a successful track record of training with both formal didactic education and mentored research experiences. The medical researchers trained in this program have made, and will continue to make, important contributions to our understanding of asthma and COPD that will lead to more effective treatment for these diseases.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007427-34
Application #
8680288
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Tigno, Xenia
Project Start
Project End
Budget Start
Budget End
Support Year
34
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Sordillo, Joanne E; Scirica, Christina V; Rifas-Shiman, Sheryl L et al. (2015) Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. J Allergy Clin Immunol 135:441-8
Sharma, Sunita; Chhabra, Divya; Kho, Alvin T et al. (2014) The genomic origins of asthma. Thorax 69:481-7
Bunyavanich, Supinda; Rifas-Shiman, Sheryl L; Platts-Mills, Thomas A et al. (2014) Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children. J Allergy Clin Immunol 133:1373-82
Hobbs, Brian D; Hersh, Craig P (2014) Integrative genomics of chronic obstructive pulmonary disease. Biochem Biophys Res Commun 452:276-86
Bunyavanich, Supinda; Rifas-Shiman, Sheryl L; Platts-Mills, Thomas A E et al. (2014) Peanut allergy prevalence among school-age children in a US cohort not selected for any disease. J Allergy Clin Immunol 134:753-5
Winkler, Thomas W; Day, Felix R; Croteau-Chonka, Damien C et al. (2014) Quality control and conduct of genome-wide association meta-analyses. Nat Protoc 9:1192-212
Duan, Q L; Lasky-Su, J; Himes, B E et al. (2014) A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics J 14:41-7
Hardin, Megan; Cho, Michael; McDonald, Merry-Lynn et al. (2014) The clinical and genetic features of COPD-asthma overlap syndrome. Eur Respir J 44:341-50
Yip, Wai-Ki; Fier, Heide; DeMeo, Dawn L et al. (2014) A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol 38:714-21
Wu, Ann Chen; Himes, Blanca E; Lasky-Su, Jessica et al. (2014) Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. J Allergy Clin Immunol 133:723-8.e3

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