This proposal defines a multi-disciplinary postdoctoral research training program to annually support six graduates of medicine, veterinary medicine, or the basic biomedical sciences. The past 29 years of this program document an impressive record of successfully training young scientists;indeed, 87% of completed trainees in the past decade (n=22) remain in research or training, and 10 received independent funding while supported by this program. Thus, we will continue to provide robust postdoctoral research training in areas highly relevant to cardiovascular biology/pathology provided by the well-funded, interactive laboratories of 20 investigators from the Departments of Biochemistry, Cellular/Structural Biology, Clinical Laboratory Sciences, Medicine, Opthalmology, Pathology, Periodontics, Pharmacology, Physiology, and Surgery at the University of Texas Health Science Center at San Antonio (UTHSCSA) and the Department of Mechanical Engineering at the University of Texas at San Antonio (UTSA). This research training program will continue to actively recruit and retain trainees from diverse backgrounds;the record of success in the past 10 years (1/3 of trainees from underrepresented groups) reflects our commitment in addressing national efforts to promote diversity in the biomedical workforce. We will also continue to recruit the most highly meritorious research trainees from throughout the best graduate and medical programs in the United States. Principal components of the training program include: (1) active participation with graded responsibility in the research laboratory of an experienced investigator;(2) a continuing research-in-progress seminar series;(3) an integrated lecture series on topics in cardiovascular (patho)biology presented by the training faculty;(4) didactic courses and seminars in the responsible conduct of research, scientific communications, and grantsmanship/peer review;(5) dual mentorship with a rigorous mentorship plan, (6) preparation of an individual development plan (IDP) and the comprehensive evaluation of annual progress, and (7) submission of an independent grant application. Trainee access to on-going departmental conferences, seminars, clinical rounds, pre- and postdoctoral courses further enhances the training experience. Research areas are encompassed within three investigative themes: (1) Inflammation, Cell Injury, and Adaptation;(2) Diabetes, and (3) Cardiovascular Pathophysiology. Integration of these overlapping research themes incorporates a range of highly relevant basic biomedical science investigations which are essential for our understanding of the genetic, biochemical, and molecular mechanisms that contribute to cardiovascular pathobiology. Given the complexities, morbidity, and mortality associated with occlusive cardiovascular disease in developed countries, this postdoctoral research training program will continue to provide scientists with the requisite skills to successfully pursue independent translational science studies directed towards the prevention and treatment of these prevalent disorders.

Public Health Relevance

Heart attacks and stroke continue to be the most common causes of death and disability in the United States and are most often the result of occlusion of blood flow to the heart or brain. Well-trained scientists are needed to investigate the causes and complications of these occlusive events. This research training program is designed to prepare young scientists to become the next generation of independent investigators who can work in teams to discover answers that will lead to the prevention and treatment of occlusive vascular disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center San Antonio
Schools of Medicine
San Antonio
United States
Zip Code
Evans, LaShauna; Myatt, Leslie (2017) Sexual dimorphism in the effect of maternal obesity on antioxidant defense mechanisms in the human placenta. Placenta 51:64-69
Sun, Y; Shen, Q; Watts, L T et al. (2016) Multimodal MRI characterization of experimental subarachnoid hemorrhage. Neuroscience 316:53-62
Zhang, Jie; Shapiro, Mark S (2016) Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve. J Physiol 594:31-7
DeLeon-Pennell, Kristine Y; Tian, Yuan; Zhang, Bai et al. (2016) CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling. Circ Cardiovasc Genet 9:14-25
Zhang, Jie; Carver, Chase M; Choveau, Frank S et al. (2016) Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron 92:461-478
Phipps, Jennifer E; Hoyt, Taylor; Vela, Deborah et al. (2016) Diagnosis of Thin-Capped Fibroatheromas in Intravascular Optical Coherence Tomography Images: Effects of Light Scattering. Circ Cardiovasc Interv 9:
Chandra, Saurav B; Mohan, Sumathy; Ford, Bridget M et al. (2016) Targeted overexpression of endothelial nitric oxide synthase in endothelial cells improves cerebrovascular reactivity in Ins2Akita-type-1 diabetic mice. J Cereb Blood Flow Metab 36:1135-42
Phipps, Jennifer E; Vela, Deborah; Hoyt, Taylor et al. (2015) Macrophages and intravascular OCT bright spots: a quantitative study. JACC Cardiovasc Imaging 8:63-72
Kar, Rekha; Kellogg 3rd, Dean L; Roman, Linda J (2015) Oxidative stress induces phosphorylation of neuronal NOS in cardiomyocytes through AMP-activated protein kinase (AMPK). Biochem Biophys Res Commun 459:393-7
Zamora, D A; Downs, K P; Ullevig, S L et al. (2015) Glutaredoxin 2a overexpression in macrophages promotes mitochondrial dysfunction but has little or no effect on atherogenesis in LDL-receptor null mice. Atherosclerosis 241:69-78

Showing the most recent 10 out of 106 publications