This proposal defines a multi-disciplinary postdoctoral research training program to annually support six graduates of medicine, veterinary medicine, or the basic biomedical sciences. The past 29 years of this program document an impressive record of successfully training young scientists;indeed, 87% of completed trainees in the past decade (n=22) remain in research or training, and 10 received independent funding while supported by this program. Thus, we will continue to provide robust postdoctoral research training in areas highly relevant to cardiovascular biology/pathology provided by the well-funded, interactive laboratories of 20 investigators from the Departments of Biochemistry, Cellular/Structural Biology, Clinical Laboratory Sciences, Medicine, Opthalmology, Pathology, Periodontics, Pharmacology, Physiology, and Surgery at the University of Texas Health Science Center at San Antonio (UTHSCSA) and the Department of Mechanical Engineering at the University of Texas at San Antonio (UTSA). This research training program will continue to actively recruit and retain trainees from diverse backgrounds;the record of success in the past 10 years (1/3 of trainees from underrepresented groups) reflects our commitment in addressing national efforts to promote diversity in the biomedical workforce. We will also continue to recruit the most highly meritorious research trainees from throughout the best graduate and medical programs in the United States. Principal components of the training program include: (1) active participation with graded responsibility in the research laboratory of an experienced investigator;(2) a continuing research-in-progress seminar series;(3) an integrated lecture series on topics in cardiovascular (patho)biology presented by the training faculty;(4) didactic courses and seminars in the responsible conduct of research, scientific communications, and grantsmanship/peer review;(5) dual mentorship with a rigorous mentorship plan, (6) preparation of an individual development plan (IDP) and the comprehensive evaluation of annual progress, and (7) submission of an independent grant application. Trainee access to on-going departmental conferences, seminars, clinical rounds, pre- and postdoctoral courses further enhances the training experience. Research areas are encompassed within three investigative themes: (1) Inflammation, Cell Injury, and Adaptation;(2) Diabetes, and (3) Cardiovascular Pathophysiology. Integration of these overlapping research themes incorporates a range of highly relevant basic biomedical science investigations which are essential for our understanding of the genetic, biochemical, and molecular mechanisms that contribute to cardiovascular pathobiology. Given the complexities, morbidity, and mortality associated with occlusive cardiovascular disease in developed countries, this postdoctoral research training program will continue to provide scientists with the requisite skills to successfully pursue independent translational science studies directed towards the prevention and treatment of these prevalent disorders.

Public Health Relevance

Heart attacks and stroke continue to be the most common causes of death and disability in the United States and are most often the result of occlusion of blood flow to the heart or brain. Well-trained scientists are needed to investigate the causes and complications of these occlusive events. This research training program is designed to prepare young scientists to become the next generation of independent investigators who can work in teams to discover answers that will lead to the prevention and treatment of occlusive vascular disease.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007446-33
Application #
8721472
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Texas Health Science Center
Department
Pathology
Type
Schools of Medicine
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Sun, Y; Shen, Q; Watts, L T et al. (2016) Multimodal MRI characterization of experimental subarachnoid hemorrhage. Neuroscience 316:53-62
Phipps, Jennifer E; Hoyt, Taylor; Vela, Deborah et al. (2016) Diagnosis of Thin-Capped Fibroatheromas in Intravascular Optical Coherence Tomography Images: Effects of Light Scattering. Circ Cardiovasc Interv 9:
DeLeon-Pennell, Kristine Y; Tian, Yuan; Zhang, Bai et al. (2016) CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac Remodeling. Circ Cardiovasc Genet 9:14-25
Zhang, Jie; Shapiro, Mark S (2016) Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve. J Physiol 594:31-7
Chandra, Saurav B; Mohan, Sumathy; Ford, Bridget M et al. (2016) Targeted overexpression of endothelial nitric oxide synthase in endothelial cells improves cerebrovascular reactivity in Ins2Akita-type-1 diabetic mice. J Cereb Blood Flow Metab 36:1135-42
San Emeterio Nateras, Oscar; Yu, Fang; Muir, Eric R et al. (2016) Intrinsic Resting-State Functional Connectivity in the Human Spinal Cord at 3.0 T. Radiology 279:262-8
Minami, Yoshiyasu; Phipps, Jennifer E; Hoyt, Taylor et al. (2015) Clinical utility of quantitative bright spots analysis in patients with acute coronary syndrome: an optical coherence tomography study. Int J Cardiovasc Imaging 31:1479-87
Berman, Jonathan M; Stockand, James D (2015) Salt and water loss in the distal colon. J Physiol 593:5229
Long, Justin A; Watts, Lora T; Li, Wei et al. (2015) The effects of perturbed cerebral blood flow and cerebrovascular reactivity on structural MRI and behavioral readouts in mild traumatic brain injury. J Cereb Blood Flow Metab 35:1852-61
Halaney, David L; Zahedivash, Aydin; Phipps, Jennifer E et al. (2015) Differences in forward angular light scattering distributions between M1 and M2 macrophages. J Biomed Opt 20:115002

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