The discipline of Hematology continues to be a model for translating basic scientific discoveries in immunology, molecular biology, and cellular biology into promising new therapies for human beings. To maximize our opportunity to translate nascent scientific knowledge into clinical hematology, we need to perpetuate the pool of gifted and highly trained physician-scientists who will translate between the laboratory and the clinic. To fully link basic science with clinical investigation, a trainee must receive rigorous laboratory training and strong mentoring in a stimulating and nurturing research environment. Unfortunately, there is a shortage of young investigators with such training in the discipline of hematology. A recent survey of directors of adult and pediatric hematology/oncology subspecialty training programs in the United States and Canada found a deficiency in fellows trained in academic Hematology (1). The study stated that, """"""""Concern is raised over the small numbers of trainees who opt for single-board eligibility in Hematology (100/o) and pursue careers in nonmalignant Hematology (<6% of graduates of adult training programs)."""""""" The Division of Hematology at Johns Hopkins is one of the few remaining free-standing Hematology Programs in the country. Thus, the purpose ofthe proposed training program is to prepare qualified individuals with an M.D. and/or Ph.D. degree for a research career in the field of Hematology. This program for research training in hematology provides interdisciplinary laboratory training for individuals preparing for full-time careers in hematology research. Trainees work on projects relevant to the biology of benign and malignant blood disorders in the laboratories of leading investigators. These research projects, in conjunction with participation in course-work, research seminars, journal clubs, laboratory meetings, and attendance at National and International meetings, afford trainees the basic knowledge and required skills to function successfully as independent investigators.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007525-30
Application #
8490721
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1982-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
30
Fiscal Year
2013
Total Cost
$180,902
Indirect Cost
$18,505
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Payer, Lindsay M; Steranka, Jared P; Yang, Wan Rou et al. (2017) Structural variants caused by Alu insertions are associated with risks for many human diseases. Proc Natl Acad Sci U S A 114:E3984-E3992
Merrill, Samuel A; Brittingham, Zachary D; Yuan, Xuan et al. (2017) Eculizumab cessation in atypical hemolytic uremic syndrome. Blood 130:368-372
Baines, Andrea C; Brodsky, Robert A (2017) Complementopathies. Blood Rev 31:213-223
Vaught, Arthur J; Gavriilaki, Eleni; Hueppchen, Nancy et al. (2016) Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome. Exp Hematol 44:390-8
Lombardi, Lindsey R; Kanakry, Christopher G; Zahurak, Marianna et al. (2016) Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre- and post-transplantation cyclophosphamide. Leuk Lymphoma 57:666-75
McDonnell, Megan H; Smith Jr, Elton T; Lipford, Edward H et al. (2016) Microgranular acute promyelocytic leukemia presenting with leukopenia and an unusual immunophenotype. Hematol Oncol Stem Cell Ther :
Gocke, Christian B; McMillan, Ross; Wang, Qiuju et al. (2016) IQGAP1 Scaffold-MAP Kinase Interactions Enhance Multiple Myeloma Clonogenic Growth and Self-Renewal. Mol Cancer Ther 15:2733-2739
Jang, Yoon-Young; Cai, Liuhong; Ye, Zhaohui (2016) Genome editing systems in novel therapies. Discov Med 21:57-64
Gerber, Jonathan M; Zeidner, Joshua F; Morse, Sarah et al. (2016) Association of acute myeloid leukemia's most immature phenotype with risk groups and outcomes. Haematologica 101:607-16
Deng, Kai; Pertea, Mihaela; Rongvaux, Anthony et al. (2015) Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature 517:381-5

Showing the most recent 10 out of 110 publications