The goal of the Research Training Program in Pediatric Cardiology is to attract and train highly qualified physician scientists and PhD scientists dedicated to advancing the understanding, diagnosis, treatment, and prevention of pediatric and congenital heart disease. We are requesting 8 trainee positions, on average including 4 with MD or MD-PhD degrees and 4 with PhD degrees. We will expose trainees to the clinical, translational, or basic research techniques that represent the current state of the art. We will also teach trainees the importance of teamwork, the clear communication of research findings, responsible conduct of human and laboratory research, and mentoring skills. A Research Training Executive Committee (RTEC), comprising the Program Directors and five current mentors, will oversee the progress of fellow training, career development, and mentoring, approve new mentors, and ensure that existing mentors meet the metrics of the training program. A Core Curriculum includes Work-in-Progress meetings, a T32 journal club, a cardiovascular seminar series, a course in statistical methods, a hands-on didactic series in cardiac anatomy, a career development seminar, and attendance at the Circulation Editorial Board meetings. Trainees will also participate in an annual retreat and quarterly informal meetings of all T32 trainees and mentors. Through these interchanges, clinically oriented trainees will gain understanding of fundamental cardiovascular biology, and basic science trainees will gain understanding of important clinical problems. An External Advisory Committee (EAC) will have three visits in the five year grant period and will meet with Program directors, mentors and trainees, as well as provide the RTEC with written reports of their findings. An Internal Advisory Committee will comprise senior scientists and experienced mentors who will facilitate effectiveness of training by suggesting strategies that have proved successful in training programs in other disciplines within our institution. Milestones and metrics for trainee progress and the training program itself are outlined and will be overseen by the RTEC. Considerable institutional support includes supplementation of trainee stipends and travel funds, and support for the EAC and program activities. Excellent training in rigorous experimental bench research and in translational and clinical investigation within an interactive and vibrant program should prepare graduates to become leaders in pediatric cardiology and cardiovascular research.
Pediatric cardiology, like all of medicine, is poised to benefit from burgeoning advancements in genetics, genomics, bioengineering, and developmental, cellular and molecular biology. It is also fertile ground for rigorous prospective clinical investigation related to bioengineering, transcatheter, and pharmacological interventions, as well as cell therapy and regeneration for selected cardiovascular diseases. The challenges of this Training Program are to recruit basic, translational, and clinical researchers to these tasks and to bridge the still substantial gap between the laboratory and the bedside in pediatric cardiology. .
|Pickard, Sarah S; Gauvreau, Kimberlee; Gurvitz, Michelle et al. (2018) A National Population-based Study of Adults With Coronary Artery Disease and Coarctation of the Aorta. Am J Cardiol 122:2120-2124|
|Zhang, Donghui; Li, Yifei; Heims-Waldron, Danielle et al. (2018) Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation. Circ Res 122:74-87|
|Wang, Gang; Yang, Luhan; Grishin, Dennis et al. (2017) Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies. Nat Protoc 12:88-103|
|Daly, Kevin P; Stack, Maria; Eisenga, Michele F et al. (2017) Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients. J Heart Lung Transplant 36:434-442|
|Freud, Lindsay R; Marx, Gerald R; Marshall, Audrey C et al. (2017) Assessment of the Melody valve in the mitral position in young children by echocardiography. J Thorac Cardiovasc Surg 153:153-160.e1|
|Bezzerides, Vassilios J; Zhang, Aifeng; Xiao, Ling et al. (2017) Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Sci Rep 7:346|
|Diniz, Gabriela Placoná; Huang, Zhan-Peng; Liu, Jianming et al. (2017) Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy. Clin Sci (Lond) 131:2885-2900|
|Prosnitz, Aaron R; Leopold, Jane; Irons, Mira et al. (2017) Pulmonary vein stenosis in patients with Smith-Lemli-Opitz syndrome. Congenit Heart Dis 12:475-483|
|Opotowsky, Alexander R; Pickard, Sarah S; Geva, Tal (2017) Imaging adult patients with discrete subvalvar aortic stenosis. Curr Opin Cardiol 32:513-520|
|Yu, Wenhua; Zhang, Fang; Wang, Shiyan et al. (2017) Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis 8:e2744|
Showing the most recent 10 out of 158 publications