This Renewal Application for a well-established Ruth L. Kirschstein Institutional National Research Service Award (T32) is focused on the postdoctoral training of M.D., M.D.-Ph.D., and Ph.D. candidates to prepare them to pursue independent careers as successful Clinician-Scientists and/or Biomedical Research Scientists, whose primary interest is the cellular and molecular mechanisms of human disease. Its primary training goal is the development of core research competencies through both informal and structured didactic exercises, coupled with an in-depth mentored research experience, in a nurturing and supportive academic medical center environment. The programmatic emphasis is on understanding the basic pathogenetic mechanisms underlying major disease processes that affect the cardiovascular, pulmonary, hematopoietic/immune, and other organ systems, through the application of the multidisciplinary research tools and strategies of modern cellular and molecular biology, immunology, genetics and genomics, integrative physiology, and bioinformatics. The current Training Program, sponsored by the National Heart, Lung and Blood Institute, has been in continuous existence since 1958, and is based in the Department of Pathology at the Brigham and Women's Hospital, a primary teaching affiliate of Harvard Medical School. While the Training Program's Core Faculty is comprised primarily of clinician-scientists and basic biomedical researchers in the Department of Pathology, trainees also are encouraged to avail themselves of a wide spectrum of opportunities afforded by research mentors/laboratories in Harvard-affiliated research/medical center institutions (e.g., The Broad Institute, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts General Hospital and Massachusetts Institute of Technology). Trainees are selected from a national pool of applicants, via a proactive recruitment process, and the Program's emphasis is on tailoring a research training experience to fit a given candidate's background, scientific interests and career goals. The overarching scientific principle is one of translational molecular pathology - the probing of disease mechanisms at a fundamental mechanistic level that yields new insights that can be translated into targeted treatments for diverse diseases and, ultimately, their prevention.
Various disease processes that affect the cardiovascular, pulmonary, hematopoietic/immune, and other organ systems - creating a major health burden - appear to share in common basic pathogenetic mechanisms. Training in the skills of modern translational molecular pathology and bioinformatics can prepare the next generation of biomedical scientists to develop effective diagnostic, therapeutic and preventive strategies, in both academic and industrial settings.
|Dobry, Allison S; Zogg, Cheryl K; Hodi, F Stephen et al. (2018) Management of metastatic melanoma: improved survival in a national cohort following the approvals of checkpoint blockade immunotherapies and targeted therapies. Cancer Immunol Immunother 67:1833-1844|
|Schaefer, Inga-Marie; Hornick, Jason L (2018) Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update. Adv Anat Pathol 25:400-412|
|Ablain, Julien; Xu, Mengshu; Rothschild, Harriet et al. (2018) Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma. Science 362:1055-1060|
|Schaefer, Inga-Marie; Fletcher, Jonathan A; Nielsen, G Petur et al. (2018) Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. Cancer Cytopathol 126:552-566|
|Sage, Peter T; Schildberg, Frank A; Sobel, Raymond A et al. (2018) Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol 200:2592-2602|
|Nudel, K; Zhao, X; Basu, S et al. (2018) Genomics of Corynebacterium striatum, an emerging multidrug-resistant pathogen of immunocompromised patients. Clin Microbiol Infect 24:1016.e7-1016.e13|
|Basu, Sankha S; Randall, Elizabeth C; Regan, Michael S et al. (2018) In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture. Anal Chem 90:4987-4991|
|McConnell, Alicia M; Mito, Jeffrey K; Ablain, Julien et al. (2018) Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. Dev Biol :|
|Palte, Michael J; Basu, Sankha S; Dahlin, Jameson L et al. (2018) Development and Validation of an Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for the Concurrent Measurement of Gabapentin, Lamotrigine, Levetiracetam, Monohydroxy Derivative of Oxcarbazepine, and Zonisamide Concentrations in Se Ther Drug Monit 40:469-476|
|Al Hmada, Youssef; Schaefer, Inga-Marie; Fletcher, Christopher D M (2018) Hibernoma Mimicking Atypical Lipomatous Tumor: 64 Cases of a Morphologically Distinct Subset. Am J Surg Pathol 42:951-957|
Showing the most recent 10 out of 136 publications