This is a competitive renewal of a multi-disciplinary, post-doctoral cardiovascular research program Sponsored by the Cardiology Unit of the Dept. of Medicine and the Depts. of Molecular Physiology and Biophysics and Pharmacology of the University of Vermont College of Medicine. This grant has been funded since 1988. The goal of the program is to provide rigorous training for both MDs and PhDs that will equip them for productive research careers in cardiovascular science. MD trainees are recruited primarily in conjunction with the clinical Cardiology Fellowship Program at the University of Vermont, while PhDs are mainly recruited through the two basic science departments. The 18 participating faculty are divided into four thematic groups: 1) Cardiac Muscle and Heart Failure, 2) Smooth Muscle, 3) Vascular Biology, and 4) Clinical Cardiology and Epidemiology. Training is centered around a focussed laboratory or clinical research experience under the supervision of a primary mentor and a secondary mentor. Interactions with participating faculty within each thematic group and across boundaries are encouraged and facilitated. Trainees in Clinical Cardiology and Epidemiology take required seminar courses in study design and biostatistics, which are open to other trainees if they are deemed useful or necessary. All trainees attend a seminar series on responsible conduct of research. Administrative and policy decisions and overall oversight of trainees'progress is accomplished by a Steering Committee composed of the Pland Drs. David Warshaw and Mark Nelson, Chairs of Molecular Physiology and Biophysics and Pharmacology, respectively. The philosophy of the training program is to provide both focus and flexibility, a collaborative environment, and carefully designed, supportive mentoring relationships.
The ulitmate goal of this Training Program Is to train phyisicans and scientists who will make meaningful contributions to the understanding, diagnosis and treatment of human cardiovascular disease.
|Tanner, Bertrand C W; McNabb, Mark; Palmer, Bradley M et al. (2014) Random myosin loss along thick-filaments increases myosin attachment time and the proportion of bound myosin heads to mitigate force decline in skeletal muscle. Arch Biochem Biophys 552-553:117-27|
|Callahan, Damien M; Bedrin, Nicholas G; Subramanian, Meenakumari et al. (2014) Age-related structural alterations in human skeletal muscle fibers and mitochondria are sex specific: relationship to single-fiber function. J Appl Physiol (1985) 116:1582-92|
|Thompson, Andrew R; Hoeprich, Gregory J; Berger, Christopher L (2013) Single-molecule motility: statistical analysis and the effects of track length on quantification of processive motion. Biophys J 104:2651-61|
|Palmer, Bradley M; Tanner, Bertrand C W; Toth, Michael J et al. (2013) An inverse power-law distribution of molecular bond lifetimes predicts fractional derivative viscoelasticity in biological tissue. Biophys J 104:2540-52|
|Wang, Yuan; Tanner, Bertrand C W; Lombardo, Andrew T et al. (2013) Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity. J Mol Cell Cardiol 54:1-8|
|Sckolnick, Maria; Krementsova, Elena B; Warshaw, David M et al. (2013) More than just a cargo adapter, melanophilin prolongs and slows processive runs of myosin Va. J Biol Chem 288:29313-22|
|Dabertrand, Fabrice; Hannah, Rachael M; Pearson, Jessica M et al. (2013) Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles. J Cereb Blood Flow Metab 33:479-82|
|Hefer, David; Yi, Ting; Selby, Donald E et al. (2012) Erythropoietin induces positive inotropic and lusitropic effects in murine and human myocardium. J Mol Cell Cardiol 52:256-63|
|Tanner, Bertrand C W; Wang, Yuan; Maughan, David W et al. (2011) Measuring myosin cross-bridge attachment time in activated muscle fibers using stochastic vs. sinusoidal length perturbation analysis. J Appl Physiol 110:1101-8|
|Palmer, Bradley M; Sadayappan, Sakthivel; Wang, Yuan et al. (2011) Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophys J 101:1661-9|
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