We seek continued support for a (renamed) training program in respiratory neurobiology at the University of Wisconsin. The program is designed to prepare pre- and post-doctoral scientists for independent careers in basic and applied biomedical research and teaching. Although the program focus on respiratory control continues, extensive changes have been made in this application: 1) G. S. Mitchell will become program director (formerly J. Dempsey), and 2) training faculty will expand from 7 to 14. Historically, our strength has been in training integrative biologists, able to conduct research with solid grounding at multiple levels of biological organization, but featuring studies on intact animals or human subjects. These training goals have been expanded to include greater emphases on cellular/molecular physiology and translational research. To accommodate these changes, we request an increase to 4 predoctoral 4 postdoctoral positions. Four main research focus groups are identified: 1) plasticity in respiratory motor control, 2) hypoxia induced gene expression, 3) sleep disordered breathing and 4)cardiorespiratory responses to physiological stimuli (e.g. hypoxia and exercise). Focus group includes trainers working at multiple levels of biological organization, but with a sufficiently common theme to assure interaction. Common scientific foundations lend cohesiveness to the training program. Trainees will benefit from the existence of multiple, complementary research focus groups, expanding their research experiences across specialization. Key elements of the proposed program include: 1) a close working relationship between trainees and a faculty supervisor; 2)cooperative mentoring of trainees; 3) long-standing and close ties among trainers; 4) a critical mass and diversity of trainers and trainees to assure quality interactions; and 5)research presentations in a variety of weekly, monthly and annual forums. Predoctoral trainees are admitted to one of several graduate degree programs according to their needs, including neuroscience, physiology or veterinary science. Predoctoral trainees may select a laboratory immediately, or rotate among trainers laboratories while completing required course work prior to deciding on a laboratory. Postdoctoral trainees (PhD, MD or DVM degree) generally enter a research laboratory based on their interests. Postdoctoral training focuses on development as an independent investigator, including the necessary research, writing and speaking skills, and a firm foundation in science ethics. Postdoctoral training typically lasts 2-3 years.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007654-20
Application #
7085543
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Rothgeb, Ann E
Project Start
1987-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
20
Fiscal Year
2006
Total Cost
$349,566
Indirect Cost
Name
University of Wisconsin Madison
Department
Biology
Type
Schools of Veterinary Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Bartman, Michelle E; Johnson, Stephen M (2018) Isolated adult turtle brainstems exhibit central hypoxic chemosensitivity. Comp Biochem Physiol A Mol Integr Physiol 225:65-73
Nichols, Nicole L; Satriotomo, Irawan; Allen, Latoya L et al. (2017) Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats. J Neurosci 37:5834-5845
Dale, Erica A; Fields, Daryl P; Devinney, Michael J et al. (2017) Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation. Exp Neurol 287:130-136
Devinney, Michael J; Nichols, Nicole L; Mitchell, Gordon S (2016) Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation. J Neurosci 36:7877-85
Nichols, Nicole L; Satriotomo, Irawan; Harrigan, Daniel J et al. (2015) Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS. Exp Neurol 273:138-50
Turner, Sara M F; Johnson, Stephen M (2015) Abrupt changes in pentobarbital sensitivity in preBötzinger complex region, hypoglossal motor nucleus, nucleus tractus solitarius, and cortex during rat transitional period (P10-P15). Respir Physiol Neurobiol 207:61-71
Devinney, Michael J; Fields, Daryl P; Huxtable, Adrianne G et al. (2015) Phrenic long-term facilitation requires PKC? activity within phrenic motor neurons. J Neurosci 35:8107-17
Huxtable, Adrianne G; Smith, Stephanie M C; Peterson, Timothy J et al. (2015) Intermittent Hypoxia-Induced Spinal Inflammation Impairs Respiratory Motor Plasticity by a Spinal p38 MAP Kinase-Dependent Mechanism. J Neurosci 35:6871-80
Moses, Kayla L; Beshish, Arij G; Heinowski, Nicole et al. (2015) Effect of body position and oxygen tension on foramen ovale recruitment. Am J Physiol Regul Integr Comp Physiol 308:R28-33
Johnson, Stephen M; Krisp, Ashley R; Bartman, Michelle E (2015) Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism. Respir Physiol Neurobiol 207:48-57

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