This application seeks renewal of support for the Vascular Biology Training Program now housed within the Center for Vascular and Inflammatory Diseases (OVID) at the University of Maryland School of Medicine in Baltimore, MD. The goals of this training program are to provide multidisciplinary training for 4 pre and 4 post doctoral scientists at the forefront of research related to the molecular and physiological basis of vascular disease and to develop a clear understanding of molecular, cellular, and physiological mechanisms that maintain health of the vasculature. The program has specific features and dedicated components to address two emerging critical needs in current cardiovascular research: 1) to provide first-rate basic science laboratory training for clinical M.D.'s (residents) to form the basis for their careers as future clinician- investigators studying the cellular and molecular basis of cardiovascular diseases relevant to their clinical disciplines, and 2) to expose pre- and post-doctoral Ph.D. trainees In basic research to clinical cardiovascular pathophysiology to provide a disease-related framework for their training. To accomplish these goals we will 1) take advantage of the multidisciplinary and highly interactive environment within the OVID and at the University of Maryland Baltimore campus to provide multidisciplinary in thrombosis, vascular biology, stem cell biology, immunology and inflammation, 2) provide comprehensive and state-of-the-art scientific training experience for clinical trainees by establishing links with the outstanding clinical faculty at the University of Maryland and with the appropriate residency training programs 3) Provide appropriate clinical experience to our pre- and post-doctoral trainees in basic research by designing both didactic and hands on components guided by both PhD and MD faculty 4) Aid all of our trainees in their path to independence with regard to obtaining extramural funding and making the critical transition from trainee to mentored independent investigators. The training program has an excellent training record of producing productive and funded scientists at academic institutions and active researchers and leaders within the Biotechnology Industry. 4 pre and 4 postdoctoral trainees can choose from 21 mentors in seven departments. The training program offers unique didactic component that provides trainees with state-of-the art knowledge in Vascular and Stem Cell Biology and Clinical Cardiovascular Disease, vigorous and unique seminar programs, and skills courses that ensure their success in a competitive science environment.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Mondoro, Traci
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Maryland Baltimore
Schools of Medicine
United States
Zip Code
Adair, Patrick; Kim, Yong Chan; Pratt, Kathleen P et al. (2016) Avidity of human T cell receptor engineered CD4(+) T cells drives T-helper differentiation fate. Cell Immunol 299:30-41
Noyes, Nathaniel C; Hampton, Brian; Migliorini, Mary et al. (2016) Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. Biochemistry 55:1204-13
Lillis, Anna P; Muratoglu, Selen Catania; Au, Dianaly T et al. (2015) LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. PLoS One 10:e0128903
Prasad, Joni M; Migliorini, Mary; Galisteo, Rebeca et al. (2015) Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain. J Biol Chem 290:17262-8
Kang, Liang-I; Isse, Kumiko; Koral, Kelly et al. (2015) Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1. Lab Invest 95:1117-29
Burrell, Bryna E; Warren, Kristi J; Nakayama, Yumi et al. (2015) Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance. Transplantation 99:1119-25
Cheng, Emily; Whitsett, Timothy G; Tran, Nhan L et al. (2015) The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion. Mol Cancer Res 13:575-83
Harris, Donald G; Benipal, Prabhjot K; Cheng, Xiangfei et al. (2015) Four-dimensional characterization of thrombosis in a live-cell, shear-flow assay: development and application to xenotransplantation. PLoS One 10:e0123015
Driesbaugh, Kathryn H; Buzza, Marguerite S; Martin, Erik W et al. (2015) Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin. J Biol Chem 290:3529-41
Nakayama, Yumi; Brinkman, C Colin; Bromberg, Jonathan S (2015) Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L. Transplantation 99:1561-7

Showing the most recent 10 out of 54 publications