Sleep disorders are increasingly recognized to be common in the American population and to have important adverse consequences, not only on behavior with an increased risk of crashes but also on the cardiovascular system. Thus, sleep disorders are a major public health problem. This application is for renewal of a postdoctoral research training program for sleep research and research in sleep disorders at the University of Pennsylvania. The overall goals of the program are to train a cadre of independent investigators on these topics with a particular focus on physician-scientists. The training program has three distinct tracks: a) basic research, b) translational research, and c) patient-oriented research. Each track combines didactic training with an intense research experience working with a mentor(s). The program utilizes established Masters Degrees at the University of Pennsylvania to amplify what is provided by this particular program. The relevant Masters degrees are the Masters in Translational Research (Track 2) and the Masters in Clinical Epidemiology (Track 3). The program utilizes the infrastructure for research in sleep and its disorders that has been developed at the University of Pennsylvania by the interdisciplinary Center for Sleep and Circadian Neurobiology. This infrastructure is for both basic and clinical research and includes a dedicated 4-bedroom sleep research facility for studies in humans, including patients with specific sleep disorders. The program utilizes a group mentorship model and a mentorship committee is established for each trainee. Trainees are given specific training not only in sleep research but also in "survival" skills, including how to write grants. Career counseling is provide to each trainee and many of the trainees go on to successful academic careers as independent investigators. The strengths of the program include: a) a stable, dedicated leadership;b) a large group of productive research-oriented faculty who work in a very collaborative fashion;c) strong institutional support;and d) major research funding for faculty to pursue research.

Public Health Relevance

Sleep disorders are common in the United States population. Indeed, given the association between obesity and common sleep disorders such as sleep apnea, the prevalence of sleep disorders is increasing. While sleep disorders represent a major public health problem, there are a limited number of investigators in the new field of sleep medicine. This is particularly the case for physician-scientists pursuing state of the art research. This research training program is focused on developing a workforce of physician-scientists studying sleep and its disorders with a secondary goal of training PhD investigators from different backgrounds.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007713-22
Application #
8629779
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Soans, Rajath E; Lim, Diane C; Keenan, Brendan T et al. (2016) Automated Protein Localization of Blood Brain Barrier Vasculature in Brightfield IHC Images. PLoS One 11:e0148411
Lyons, M Melanie; Bhatt, Nitin Y; Kneeland-Szanto, Elizabeth et al. (2016) Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility. Biomark Med 10:265-300
Paterno, Rosalia; Metheny, Hannah; Xiong, Guoxiang et al. (2016) Mild Traumatic Brain Injury Decreases Broadband Power in Area CA1. J Neurotrauma 33:1645-9
Kayser, Matthew S; Dalmau, Josep (2016) Anti-NMDA receptor encephalitis, autoimmunity, and psychosis. Schizophr Res 176:36-40
Gerstner, Jason R; Lenz, Olivia; Vanderheyden, William M et al. (2016) Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila. J Neurosci Res :
Pechar, Joanne; Lyons, M Melanie (2016) Acute Compartment Syndrome of the Lower Leg: A Review. J Nurse Pract 12:265-270
Veatch, Olivia J; Maxwell-Horn, Angela C; Malow, Beth A (2015) Sleep in Autism Spectrum Disorders. Curr Sleep Med Rep 1:131-140
Nelson, Matthew D; Janssen, Tom; York, Neil et al. (2015) FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans. PLoS One 10:e0142938
Xia, Wenqing; Wang, Shaohua; Spaeth, Andrea M et al. (2015) Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study. Biomed Res Int 2015:719076
Dumoulin Bridi, Michelle C; Aton, Sara J; Seibt, Julie et al. (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain. Sci Adv 1:e1500105

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