Sleep disorders are increasingly recognized to be common in the American population and to have important adverse consequences, not only on behavior with an increased risk of crashes but also on the cardiovascular system. Thus, sleep disorders are a major public health problem. This application is for renewal of a postdoctoral research training program for sleep research and research in sleep disorders at the University of Pennsylvania. The overall goals of the program are to train a cadre of independent investigators on these topics with a particular focus on physician-scientists. The training program has three distinct tracks: a) basic research, b) translational research, and c) patient-oriented research. Each track combines didactic training with an intense research experience working with a mentor(s). The program utilizes established Masters Degrees at the University of Pennsylvania to amplify what is provided by this particular program. The relevant Masters degrees are the Masters in Translational Research (Track 2) and the Masters in Clinical Epidemiology (Track 3). The program utilizes the infrastructure for research in sleep and its disorders that has been developed at the University of Pennsylvania by the interdisciplinary Center for Sleep and Circadian Neurobiology. This infrastructure is for both basic and clinical research and includes a dedicated 4-bedroom sleep research facility for studies in humans, including patients with specific sleep disorders. The program utilizes a group mentorship model and a mentorship committee is established for each trainee. Trainees are given specific training not only in sleep research but also in "survival" skills, including how to write grants. Career counseling is provide to each trainee and many of the trainees go on to successful academic careers as independent investigators. The strengths of the program include: a) a stable, dedicated leadership;b) a large group of productive research-oriented faculty who work in a very collaborative fashion;c) strong institutional support;and d) major research funding for faculty to pursue research.

Public Health Relevance

Sleep disorders are common in the United States population. Indeed, given the association between obesity and common sleep disorders such as sleep apnea, the prevalence of sleep disorders is increasing. While sleep disorders represent a major public health problem, there are a limited number of investigators in the new field of sleep medicine. This is particularly the case for physician-scientists pursuing state of the art research. This research training program is focused on developing a workforce of physician-scientists studying sleep and its disorders with a secondary goal of training PhD investigators from different backgrounds.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Ryu, Min-Hyung; Kang, In-Hye; Nelson, Mathew D et al. (2014) Engineering adenylate cyclases regulated by near-infrared window light. Proc Natl Acad Sci U S A 111:10167-72
Lim, Miranda M; Gerstner, Jason R; Holtzman, David M (2014) The sleep-wake cycle and Alzheimer's disease: what do we know? Neurodegener Dis Manag 4:351-62
Goel, Namni; Abe, Takashi; Braun, Marcia E et al. (2014) Cognitive workload and sleep restriction interact to influence sleep homeostatic responses. Sleep 37:1745-56
Kayser, Matthew S; Dalmau, Josep (2014) Anti-NMDA receptor encephalitis, autoimmunity, and psychosis. Schizophr Res :
Li, Zi-Lun; Ebrahimi, Behzad; Zhang, Xin et al. (2014) Obesity-metabolic derangement exacerbates cardiomyocyte loss distal to moderate coronary artery stenosis in pigs without affecting global cardiac function. Am J Physiol Heart Circ Physiol 306:H1087-101
Grandner, Michael A; Jackson, Nicholas; Gooneratne, Nalaka S et al. (2014) The development of a questionnaire to assess sleep-related practices, beliefs, and attitudes. Behav Sleep Med 12:123-42
Brown, Marishka K; Chan, May T; Zimmerman, John E et al. (2014) Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis. Neurobiol Aging 35:1431-41
Kayser, Matthew S; Yue, Zhifeng; Sehgal, Amita (2014) A critical period of sleep for development of courtship circuitry and behavior in Drosophila. Science 344:269-74
Li, Yanpeng; Panossian, Lori A; Zhang, Jing et al. (2014) Effects of chronic sleep fragmentation on wake-active neurons and the hypercapnic arousal response. Sleep 37:51-64
Pak, Victoria M; Grandner, Michael A; Pack, Allan I (2014) Circulating adhesion molecules in obstructive sleep apnea and cardiovascular disease. Sleep Med Rev 18:25-34

Showing the most recent 10 out of 45 publications