This training program provides two years of basic research training in vascular surgery for academic clinicians. It addresses the absence of adequate research training for vascular surgeons as it applies to specific areas of clinical disease. Research training in molecular and cell biology, biomechanics, coagulation thrombosis, and angiogenesis is provided with a focus on clinically relevant problems such as atherogenesis, intimal hyperplasia, prosthetic/host interactions and thrombosis. A new component is the availability of mentored advanced outcomes research training Trainees pursue a program of intense research activity supplemented with course work in research design, statistics, and evaluation of published research. The program is conducted and closely supervised by the program director, co-director and mentors who have well-established records of peer-reviewed research, and who were selected both for the current research activities and their proven commitment to train research fellows. Individual mentors are chosen from the program's faculty on the basis of the background and research interest of the individual trainee, and the trainees carry out their own projects under the close guidance of their mentor. Laboratory training can be supplemented by graduate level training at Harvard Medical School the Department of Health Care Policy and Research and Harvard's Faculty of Arts and Sciences, with course selection complementing laboratory endeavors. Upon completion of the program, trainees are capable of independent research and possess the scientific and research background needed to obtain competitive peer-reviewed grants;they have the abilities and knowledge necessary to provide translational expertise as they join medical school faculties. Selection of the trainees is based on candidates'demonstrated ability and career choice of academic practice. Applicants are resident physicians who have completed two, three or five years (i.e. is board eligible) of post-graduate surgical training. Trainees commit to two years of training;trainees desiring a shorter training period are not considered. Only those applicants with career goals in academic surgery, with a keen interest in basic resarch or outcomes research in vascular surgery, are compatible. Candidates pursuing a fellowship during a program of clinical traning must provide evidence that they will be accepted back into that program upon completion of their research training. Trainees are not involved in any clinical activities unless research related.

Public Health Relevance

Vascular Surgeons provide a practical "hands on" perspective on the relevant problems of devices and interventions on blood vessels. This program creates a cadre of surgeons with expertise in research fundamentals essential to frontline 'bench to bedside to public policy'programs in treatment of vascular disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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Beth Israel Deaconess Medical Center
United States
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Lo, Ruby C; Fokkema, Margriet T M; Curran, Thomas et al. (2015) Routine use of ultrasound-guided access reduces access site-related complications after lower extremity percutaneous revascularization. J Vasc Surg 61:405-12
Hawkins, Alexander T; Henry, Antonia J; Crandell, David M et al. (2014) A systematic review of functional and quality of life assessment after major lower extremity amputation. Ann Vasc Surg 28:763-80
Pradhan-Nabzdyk, Leena; Huang, Chenyu; LoGerfo, Frank W et al. (2014) Current siRNA targets in the prevention and treatment of intimal hyperplasia. Discov Med 18:125-32
Nabzdyk, Christoph S; Chun, Maggie C; Oliver-Allen, Hunter S et al. (2014) Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts. Biomaterials 35:3071-9
Gu, Zhimin; Zhou, Wen; Huang, Junwei et al. (2014) Nek2 is a novel regulator of B cell development and immunological response. Biomed Res Int 2014:621082
Swain, JaBaris D; Pugliese, Daniel N; Mucumbitsi, Joseph et al. (2014) Partnership for sustainability in cardiac surgery to address critical rheumatic heart disease in sub-Saharan Africa: the experience from Rwanda. World J Surg 38:2205-11
Hawkins, Alexander T; Berger, David L; Shellito, Paul C et al. (2014) Wound dehiscence after abdominoperineal resection for low rectal cancer is associated with decreased survival. Dis Colon Rectum 57:143-50
Eckers, Jaimee C; Kalen, Amanda L; Sarsour, Ehab H et al. (2014) Forkhead box M1 regulates quiescence-associated radioresistance of human head and neck squamous carcinoma cells. Radiat Res 182:420-9
Zhang, Jennifer Q; Curran, Thomas; McCallum, John C et al. (2014) Risk factors for readmission after lower extremity bypass in the American College of Surgeons National Surgery Quality Improvement Program. J Vasc Surg 59:1331-9
Mauro, Christine R; Tao, Ming; Yu, Peng et al. (2014) Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury. J Vasc Surg :

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