This application requests continued support for the highly successful postdoctoral training program in cardiovascular research in the Division of Cardiology at Emory University School of Medicine. The proposed program will extend our laboratory, translational and clinical research curriculum that has developed an impressive record of training outstanding postdoctoral fellows. The Emory University Cardiology Research Division has become recognized as a leader in research on the role of oxidative stress in vascular disease. The trainees of this program have been very successful in obtaining independent positions in academics. In the last 10 years of this training grant, eleven graduates (20%) of our program are faculty members in American medical schools. We have had several fellows who have been winners or finalists for national young investigator awards. Two years of funding are requested for 8 post-doctoral fellows. The 25 mentors included in this application provide a broad-based, multidisciplinary environment ideally suited to provide an outstanding educational experience for trainees. Participating faculty are drawn from the Divisions/Departments of Cardiology, Radiology, Biochemistry, Biomedical Engineering, and the Winship Cancer Center at Emory University. All have established funding and publication records as well as documented success in training productive members of the scientific community. The training program is structured around a mentor-based environment supplemented with an extensive array of didactic educational opportunities. In summary, the proposed cardiovascular research training program will provide a unique opportunity for multidisciplinary training in basic and clinical vascular biology. Successful trainees will be well equipped to initiate a research career in academic cardiology.

Public Health Relevance

We propose to conduct a training program in the Division of Cardiology at Emory University School of Medicine over the next five years that will extend our laboratory, transitional and clinical research curriculum that has developed outstanding postdoctoral fellows over the previous five years. The 25 mentors that have agreed to support the training grant come from many different Departments and Divisions at the University allowing the training fellows a more diverse learning experience. Emerging the fellows into this multidisciplinary environment will allow for better equipped research careers in academic cardiology.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Emory University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Corban, Michel T; Hung, Olivia Y; Eshtehardi, Parham et al. (2014) Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies. J Am Coll Cardiol 63:2346-55
Naqvi, Nawazish; Li, Ming; Calvert, John W et al. (2014) A proliferative burst during preadolescence establishes the final cardiomyocyte number. Cell 157:795-807
Duran, Charity; San Martín, Alejandra (2014) Do endothelial cells eat tryptophan to die? Circ Res 114:406-8
Samady, Habib; Hung, Olivia Y (2013) Coronary microvasculature: small vessels with large impact. Circ Cardiovasc Interv 6:323-5
Xiong, Shiqin; Salazar, Gloria; Patrushev, Nikolay et al. (2013) Peroxisome proliferator-activated receptor ? coactivator-1? is a central negative regulator of vascular senescence. Arterioscler Thromb Vasc Biol 33:988-98
Dikalov, Sergey I; Li, Wei; Doughan, Abdulrahman K et al. (2012) Mitochondrial reactive oxygen species and calcium uptake regulate activation of phagocytic NADPH oxidase. Am J Physiol Regul Integr Comp Physiol 302:R1134-42
Hendley, Yolanda; Zhao, Liping; Coverson, Dorothy L et al. (2011) Differences in weight perception among blacks and whites. J Womens Health (Larchmt) 20:1805-11
Mangalat, Deepa; Kalogeropoulos, Andreas; Georgiopoulou, Vasiliki et al. (2009) Value of Cardiac CT in Patients With Heart Failure. Curr Cardiovasc Imaging Rep 2:410-417
Guzik, Tomasz J; Chen, Wei; Gongora, Maria C et al. (2008) Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. J Am Coll Cardiol 52:1803-9
Dikalov, Sergey I; Li, Wei; Mehranpour, Payam et al. (2007) Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay. Biochem Pharmacol 73:972-80

Showing the most recent 10 out of 17 publications