This application is a competitive renewal of the present Multidisciplinary Training Program in Lung Disease (HL07749). The goal of the program is produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of pulmonary disorders. The program proposes to support 12 postdoctoral fellows (M.D.s and Ph.D.s) per year. The investigative approaches available to trainees include disciplines applicable at the molecular, cellular, tissue, organ, whole animal and clinical population levels. The program utilizes faculty trainers from the Medical School, School of Public Health, the College of Pharmacy, and the College of Engineering at the University of Michigan. Medical School faculty trainers are appointed in the Departments of Internal Medicine, Pathology, Radiology, Human Genetics, Microbiology &Immunology, Molecular and Integrative Physiology, Neurology, and Pediatrics. The School of Public Health trainers are appointed in the Departments of Epidemiology and Biostatistics. The College of Engineering trainers are appointed in the Department of Biomedical Engineering. A close relationship between a primary mentor and a co-mentor(s) with the trainee is the foundation of the training experience. This laboratory experience is supplemented by a core group of lectures;workshops, core conferences, and training in responsible research conduct, career planning, communication skills, and grant writing. Emphasis is placed on personal instruction specifically designed for individual trainees. New faculty and core lectures have been added to further solidify the disciplines of bioinformatics, genetics, metabolomics, and proteomics. Considerable emphasis has been placed on multidisciplinary interactions and providing opportunities to develop academic careers in areas of scientific need. Emerging areas of growth in our program include host-microbe interactions, transplantation biology, progenitor cell biology;health services research and multi- institutional disease-specific clinical networks for research. Postdoctoral trainees in the clinical sciences can acquire a Master's Degree from the School of Public Health. A broad range of research topics is available to trainees including the pathobiology of fibrotic lung disease, host defense mechanisms, lymphocyte-macrophage interactions, epithelial cell biology, fibroblast biology, tumor biology, eicosanoid biochemistry, granulocyte biology, progenitor cell biology, bioinformatics, epidemiology, outcomes in lung disease, physician decision making, economic assessment of medical interventions, appropriate utilization of medical technology and medical ethics. Fellows and mentors are reviewed by a committee that monitors the training and career development of fellows and promotes mentoring skills. Over the past 5 years, 6 underrepresented minorities have completed our training program. Eighty eight (88%) of graduates trained in the past 10 years are currently in academic or equivalent positions, indicative of the program's success

Public Health Relevance

The University of Michigan Multidisciplinary Training Program in Lung Disease provides research training for M.D. and Ph.D. scientists in both laboratory-based and clinical studies. The purpose of this training is to produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of lung disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
Zip Code
Salisbury, Margaret L; Xia, Meng; Zhou, Yueren et al. (2016) Idiopathic Pulmonary Fibrosis: Gender-Age-Physiology Index Stage for Predicting Future Lung Function Decline. Chest 149:491-8
Valley, Thomas S; Ryan, Andrew M; Cooke, Colin R (2016) Intensive Care Unit Admission and Mortality Among Medicare Beneficiaries With Pneumonia--Reply. JAMA 315:1285
Sjoding, Michael W; Valley, Thomas S; Prescott, Hallie C et al. (2016) Rising Billing for Intermediate Intensive Care among Hospitalized Medicare Beneficiaries between 1996 and 2010. Am J Respir Crit Care Med 193:163-70
Sjoding, Michael W; Hyzy, Robert C (2016) Recognition and Appropriate Treatment of the Acute Respiratory Distress Syndrome Remains Unacceptably Low. Crit Care Med 44:1611-2
Valley, Thomas S; Walkey, Allan J; Lindenauer, Peter K et al. (2016) Association Between Noninvasive Ventilation and Mortality Among Older Patients With Pneumonia. Crit Care Med :
Valley, Thomas S; Fagerlin, Angela (2016) Disruptive Technology. Can Electronic Portals Promote Communication in the Intensive Care Unit? Ann Am Thorac Soc 13:309-10
Speth, Jennifer M; Bourdonnay, Emilie; Penke, Loka Raghu Kumar et al. (2016) Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. J Immunol 196:5112-20
Sjoding, Michael W; Liu, Vincent X (2016) Can You Read Me Now? Unlocking Narrative Data with Natural Language Processing. Ann Am Thorac Soc 13:1443-5
Xu, Jintao; Eastman, Alison J; Flaczyk, Adam et al. (2016) Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection. MBio 7:
Valley, Thomas S; Sjoding, Michael W; Goldberger, Zachary D et al. (2016) ICU Use and Quality of Care for Patients With Myocardial Infarction and Heart Failure. Chest 150:524-32

Showing the most recent 10 out of 196 publications