This application is a competitive renewal of the present Multidisciplinary Training Program in Lung Disease (HL07749). The goal of the program is produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of pulmonary disorders. The program proposes to support 12 postdoctoral fellows (M.D.s and Ph.D.s) per year. The investigative approaches available to trainees include disciplines applicable at the molecular, cellular, tissue, organ, whole animal and clinical population levels. The program utilizes faculty trainers from the Medical School, School of Public Health, the College of Pharmacy, and the College of Engineering at the University of Michigan. Medical School faculty trainers are appointed in the Departments of Internal Medicine, Pathology, Radiology, Human Genetics, Microbiology &Immunology, Molecular and Integrative Physiology, Neurology, and Pediatrics. The School of Public Health trainers are appointed in the Departments of Epidemiology and Biostatistics. The College of Engineering trainers are appointed in the Department of Biomedical Engineering. A close relationship between a primary mentor and a co-mentor(s) with the trainee is the foundation of the training experience. This laboratory experience is supplemented by a core group of lectures;workshops, core conferences, and training in responsible research conduct, career planning, communication skills, and grant writing. Emphasis is placed on personal instruction specifically designed for individual trainees. New faculty and core lectures have been added to further solidify the disciplines of bioinformatics, genetics, metabolomics, and proteomics. Considerable emphasis has been placed on multidisciplinary interactions and providing opportunities to develop academic careers in areas of scientific need. Emerging areas of growth in our program include host-microbe interactions, transplantation biology, progenitor cell biology;health services research and multi- institutional disease-specific clinical networks for research. Postdoctoral trainees in the clinical sciences can acquire a Master's Degree from the School of Public Health. A broad range of research topics is available to trainees including the pathobiology of fibrotic lung disease, host defense mechanisms, lymphocyte-macrophage interactions, epithelial cell biology, fibroblast biology, tumor biology, eicosanoid biochemistry, granulocyte biology, progenitor cell biology, bioinformatics, epidemiology, outcomes in lung disease, physician decision making, economic assessment of medical interventions, appropriate utilization of medical technology and medical ethics. Fellows and mentors are reviewed by a committee that monitors the training and career development of fellows and promotes mentoring skills. Over the past 5 years, 6 underrepresented minorities have completed our training program. Eighty eight (88%) of graduates trained in the past 10 years are currently in academic or equivalent positions, indicative of the program's success

Public Health Relevance

The University of Michigan Multidisciplinary Training Program in Lung Disease provides research training for M.D. and Ph.D. scientists in both laboratory-based and clinical studies. The purpose of this training is to produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of lung disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007749-21
Application #
8414022
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
1993-07-01
Project End
2018-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
21
Fiscal Year
2013
Total Cost
$792,163
Indirect Cost
$56,238
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Tolle, Leslie; Yu, Fu-shin; Kovach, Melissa A et al. (2015) Redundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa. J Innate Immun 7:177-86
Dickson, Robert P; Erb-Downward, John R; Freeman, Christine M et al. (2014) Changes in the lung microbiome following lung transplantation include the emergence of two distinct Pseudomonas species with distinct clinical associations. PLoS One 9:e97214
Theriot, Casey M; Young, Vincent B (2014) Microbial and metabolic interactions between the gastrointestinal tract and Clostridium difficile infection. Gut Microbes 5:86-95
Martinez, Carlos H; Okajima, Yuka; Murray, Susan et al. (2014) Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res 15:62
Hashway, S A; Bergin, I L; Bassis, C M et al. (2014) Impact of a hormone-releasing intrauterine system on the vaginal microbiome: a prospective baboon model. J Med Primatol 43:89-99
Martinez, Carlos H; Kim, Victor; Chen, Yahong et al. (2014) The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med 108:491-9
Murdock, Benjamin J; Teitz-Tennenbaum, Seagal; Chen, Gwo-Hsiao et al. (2014) Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection. J Immunol 193:4107-16
Martinez, Carlos H; St Jean, Beth L; Plauschinat, Craig A et al. (2014) Internet access and use by COPD patients in the National Emphysema/COPD Association Survey. BMC Pulm Med 14:66
Martinez, Carlos H; Moy, Marilyn L; Nguyen, Huong Q et al. (2014) Taking Healthy Steps: rationale, design and baseline characteristics of a randomized trial of a pedometer-based Internet-mediated walking program in veterans with chronic obstructive pulmonary disease. BMC Pulm Med 14:12
Murdock, Benjamin J; Huffnagle, Gary B; Olszewski, Michal A et al. (2014) Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production. Infect Immun 82:937-48

Showing the most recent 10 out of 78 publications