This application for competing renewal of the Training Program in Mechanisms of Vascular Disease integrates the strength and diversity of multidisciplinary research In vascular biology at Vanderbilt University and Meharry Medical College into a cohesive program for specialized training of new research scientists. Participating departments at Vanderbilt include Biochemistry, Biomedical Engineering, Cancer Biology, Cell &Developmental Biology, Microbiology &Immunology, Molecular Physiology &Biophysics, Pathology, Pharmacology, Medicine, and Pediatrics, and at Meharry, Microbial Pathogenesis and Immune Response and Neurobiology and Neurotoxicology. Training will be offered in five diverse areas of research, interconnected by their focus on significant aspects of vascular biology. The areas are: (1) Microbial Vascular Diseases;(2) Atherosclerosis, Obesity, and Hypertension;(3) Cardiovascular Development and Vasculogenesis;(4) Angiogenesis and Tissue Remodeling;and (5) Thrombosis and Hemostasis. These broadly defined research areas focus on advancing the understanding of the mechanism(s) underlying vascular diseases including;viral, bacterial, or parasitic Infections that commandeer the cardiovascular system to propagate disease;atherosclerosis and its relationship to obesity and hypertension;developmental and congenital cardiovascular diseases and their repair;angiogenesis associated with tumorlgenesis and the role of extracellular matrix and molecular mediators;and molecular and cellular mechanisms of thrombosis in stroke and heart attack. Each focus area consists of 5-10 investigators. The program will support 5 predoctoral and 3 postdoctoral (M.D. and/or Ph.D.) trainees. Predoctoral training will lead to a degree In one of the basic sciences. Dissertation research will focus on a project within the specialized area of a training-grant mentor. Postdoctoral training will consist primarily of laboratory research under the guidance of a faculty mentor from the training grant and a co-mentor. All predoctoral and postdoctoral trainees will be required to participate in the courses. Cellular and Molecular Basis of Vascular Disease, taught by the participating faculty, courses on Fundamentals of Scientific Communication, and Biostatistics, and other courses depending on the background and specialized research interests of the trainee. Trainees are also required to participate in the Vascular Biology and Workin- Progress Seminars, the annual Vascular Biology Retreat, selected departmental research seminars, and training in Responsible Conduct of Research. Ample space and state-of-the-art instrumentation are available in the laboratories of the participating faculty.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007751-20
Application #
8666018
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Kline, Crystal F; Mohler, Peter J (2014) Defective interactions of protein partner with ion channels and transporters as alternative mechanisms of membrane channelopathies. Biochim Biophys Acta 1838:723-30
Lowery, Jonathan W; Amich, Jose M; Andonian, Alex et al. (2014) N-linked glycosylation of the bone morphogenetic protein receptor type 2 (BMPR2) enhances ligand binding. Cell Mol Life Sci 71:3165-72
Covarrubias, Roman; Wilhelm, Ashley J; Major, Amy S (2014) Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells. PLoS One 9:e102236
Hansen, Amanda G; Arnold, Shanna A; Jiang, Ming et al. (2014) ALCAM/CD166 is a TGF-?-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res 74:1404-15
Ashbrook, Alison W; Burrack, Kristina S; Silva, Laurie A et al. (2014) Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice. J Virol 88:12180-92
O'Brien, Christine M; Vargis, Elizabeth; Paria, Bibhash C et al. (2014) Raman spectroscopy provides a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo. Acta Paediatr 103:715-21
Hansen, Amanda G; Freeman, Tanner J; Arnold, Shanna A et al. (2013) Elevated ALCAM shedding in colorectal cancer correlates with poor patient outcome. Cancer Res 73:2955-64
Farrand, Allison J; Reniere, Michelle L; Ingmer, Hanne et al. (2013) Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system. J Bacteriol 195:5041-50
Lai, Caroline M; Mainou, Bernardo A; Kim, Kwang S et al. (2013) Directional release of reovirus from the apical surface of polarized endothelial cells. MBio 4:e00049-13
Liu, Yan; Hawkins, Oriana E; Su, Yingjun et al. (2013) Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-?B impairs this drug-induced senescence. EMBO Mol Med 5:149-66

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