This application for competing renewal of the Training Program in Mechanisms of Vascular Disease integrates the strength and diversity of multidisciplinary research In vascular biology at Vanderbilt University and Meharry Medical College into a cohesive program for specialized training of new research scientists. Participating departments at Vanderbilt include Biochemistry, Biomedical Engineering, Cancer Biology, Cell &Developmental Biology, Microbiology &Immunology, Molecular Physiology &Biophysics, Pathology, Pharmacology, Medicine, and Pediatrics, and at Meharry, Microbial Pathogenesis and Immune Response and Neurobiology and Neurotoxicology. Training will be offered in five diverse areas of research, interconnected by their focus on significant aspects of vascular biology. The areas are: (1) Microbial Vascular Diseases;(2) Atherosclerosis, Obesity, and Hypertension;(3) Cardiovascular Development and Vasculogenesis;(4) Angiogenesis and Tissue Remodeling;and (5) Thrombosis and Hemostasis. These broadly defined research areas focus on advancing the understanding of the mechanism(s) underlying vascular diseases including;viral, bacterial, or parasitic Infections that commandeer the cardiovascular system to propagate disease;atherosclerosis and its relationship to obesity and hypertension;developmental and congenital cardiovascular diseases and their repair;angiogenesis associated with tumorlgenesis and the role of extracellular matrix and molecular mediators;and molecular and cellular mechanisms of thrombosis in stroke and heart attack. Each focus area consists of 5-10 investigators. The program will support 5 predoctoral and 3 postdoctoral (M.D. and/or Ph.D.) trainees. Predoctoral training will lead to a degree In one of the basic sciences. Dissertation research will focus on a project within the specialized area of a training-grant mentor. Postdoctoral training will consist primarily of laboratory research under the guidance of a faculty mentor from the training grant and a co-mentor. All predoctoral and postdoctoral trainees will be required to participate in the courses. Cellular and Molecular Basis of Vascular Disease, taught by the participating faculty, courses on Fundamentals of Scientific Communication, and Biostatistics, and other courses depending on the background and specialized research interests of the trainee. Trainees are also required to participate in the Vascular Biology and Workin- Progress Seminars, the annual Vascular Biology Retreat, selected departmental research seminars, and training in Responsible Conduct of Research. Ample space and state-of-the-art instrumentation are available in the laboratories of the participating faculty.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007751-20
Application #
8666018
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1994-07-01
Project End
2015-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Arnette, Christopher; Frye, Keyada; Kaverina, Irina (2016) Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking. PLoS One 11:e0148996
Pfaltzgraff, Elise R; Roth, Gretchen M; Miller, Paul M et al. (2016) Loss of CENP-F results in distinct microtubule-related defects without chromosomal abnormalities. Mol Biol Cell 27:1990-9
Bensing, Barbara A; Loukachevitch, Lioudmila V; McCulloch, Kathryn M et al. (2016) Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. J Biol Chem 291:7230-40
Ashbrook, Alison W; Lentscher, Anthony J; Zamora, Paula F et al. (2016) Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio 7:
Hawman, David W; Fox, Julie M; Ashbrook, Alison W et al. (2016) Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence. Cell Rep 16:1326-38
Bartlett, Jacquelaine; Predazzi, Irene M; Williams, Scott M et al. (2016) Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? New Insights From the Framingham Offspring Study. Circ Cardiovasc Qual Outcomes 9:206-12
Pawlikowski, Jeffrey S; Brock, Claire; Chen, Sheau-Chiann et al. (2015) Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling. J Invest Dermatol 135:2093-101
McCulloch, Kathryn M; McCranie, Emilianne K; Smith, Jarrod A et al. (2015) Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proc Natl Acad Sci U S A 112:11547-52
Smith, Everett Clinton; Case, James Brett; Blanc, Hervé et al. (2015) Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity. J Virol 89:6418-26
Smith, Scott A; Silva, Laurie A; Fox, Julie M et al. (2015) Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. Cell Host Microbe 18:86-95

Showing the most recent 10 out of 114 publications