The goal of this Training Grant in Pulmonary and Cardiovascular Biology is to establish a training program for t the enhancement of basic research training in critical aspects of mammalian embryonic and perinatal biology I by providing stipends for three postdoctoral associates and for three predoctoral candidates within the ! University of Cincinnati Graduate Programs. The program draws heavily upon integrated, innovative, andl established Graduate Programs for the study of molecular, developmental, and cell biology and benefits from related programs supported by the NHLBI. This program identifies and recruits promising young doctoral and postdoctoral candidates who will complete their doctoral degree, or a postdoctoral training program. Special attention will be given to recruitment of minorities and to M.D. candidates for this program. Postdoctoral trainees will have the M.D. or Ph.D. degree, or both, and will be selected on a competitive basis. Scientific guidance, career development and course work will be obtained within the graduate programs at the University of Cincinnati College of Medicine in which the training faculty participate. The program has brought together 25 distinguished and well-established investigators with experience using contemporary molecular and cellular strategies to study the developmental biology of tung, heart and blood at Cincinnati Children's Research Foundation and at the University of Cincinnati College of Medicine. These faculty share research interests and have a long history of collaboration in developmental science. The major themes include: study of gene expression during mammalian embryogenesis, gene targeting, and the use of transgenic mice to study gene function and regulation with the developing mouse. The grant will include an administrative core consisting of the Principal Investigator, Executive Committee, external and internal Advisory Boards. Ongoing studies will include a course focused to ethical issues in the conduct of science. Predoctoral trainees will obtain their Ph.D. degrees in the Developmental Biology Graduate Program, Biomedical Sciences Degree Program, Department of Anatomy and Cell Biology, or Department of Molecular Genetics, Biochemistry and Microbiology, at the University of Cincinnati College of Medicine. Regular research meetings and several pertinent seminar series further enhance the program. Progress of each trainee will be reviewed annually by the Executive Committee.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007752-17
Application #
7778809
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
1994-07-15
Project End
2014-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
17
Fiscal Year
2010
Total Cost
$269,136
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Higano, Nara S; Hahn, Andrew D; Tkach, Jean A et al. (2017) Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magn Reson Med 77:1284-1295
Hahn, Andrew D; Higano, Nara S; Walkup, Laura L et al. (2017) Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system. J Magn Reson Imaging 45:463-471
Stevens, Mariana L; Chaturvedi, Praneet; Rankin, Scott A et al. (2017) Genomic integration of Wnt/?-catenin and BMP/Smad1 signaling coordinates foregut and hindgut transcriptional programs. Development 144:1283-1295
Sallese, Anthony; Suzuki, Takuji; McCarthy, Cormac et al. (2017) Targeting cholesterol homeostasis in lung diseases. Sci Rep 7:10211
Verma, A H; Bueter, C L; Rothenberg, M E et al. (2017) Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2(-/-) mice. Mucosal Immunol 10:194-204
Rindler, Tara N; Hinton, Robert B; Salomonis, Nathan et al. (2017) Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics. Sci Rep 7:39276
Thomen, Robert P; Walkup, Laura L; Roach, David J et al. (2017) Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatric patients. J Cyst Fibros 16:275-282
Chung, Eunah; Deacon, Patrick; Marable, Sierra et al. (2016) Notch signaling promotes nephrogenesis by downregulating Six2. Development 143:3907-3913
Munnamalai, Vidhya; Fekete, Donna M (2016) Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner. Development 143:4003-4015
Walkup, Laura L; Thomen, Robert P; Akinyi, Teckla G et al. (2016) Feasibility, tolerability and safety of pediatric hyperpolarized (129)Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis. Pediatr Radiol 46:1651-1662

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