This application is for renewal of a research training grant in cardiothoracic surgery that has been continuously funded since 1994. It is anticipated that in the next ten years there will be a shortage of cardiothoarcic surgeons. To meet the future needs it is essential that we train an increased number of academic surgeons. An essential element is training these individuals to be independent investigators. Therefore, the overall aims of the program are to provide a stimulating environment and research training for academic cardiothoracic surgeons. The specific goals are to:1)attract the most innovative, inquisitive, diverse, and motivated candidates;2) provide them with the highest possible level of training in the basic science of cardiovascular and pulmonary physiology and pathology;and 3)foster critical thought to prepare the trainees for an independent academic career and leadership role. A strength of the program is its interdisciplinary approach to scientific problem solving in which clinically recognized problems are studied in animal models of human disease at the integrative, cellular, and molecular levels, which can then be translated to clinical solutions. A key component of this training program is the faculty, which includes 26 faculty members with over $22 million of NIH support and extensive experience with research mentoring. They represent four separate departments with a history of collaborative research. Over the last 25 years, our laboratory has trained 72 postdoctoral research fellows. Of these 46 (64%) are in academic medicine. Six are division chiefs or department chairpersons, and one is a principal investigator at the NIH. The NIH T32 training grant has been key support for this training. Prior to the start of the present NIH training grant only 7% of trainees were female and 3% were from underrepresented minorities. Since the start of this training grant in 1994, 26% of trainees have been female and 10% have been minorities. Many of them are in leadership positions in their institutions. We propose to continue this training program and request support for five trainees.

Public Health Relevance

It is anticipated that there will be a shortage of heart and lung surgeons in the next decade. To meet this need it is essential that there are strong medical school programs to train surgeons. These surgeons need to be independent researchers so that they can advance the practice of cardiac and lung surgery and train the next generation of surgeons.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007776-18
Application #
8494662
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1994-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
18
Fiscal Year
2013
Total Cost
$264,905
Indirect Cost
$18,289
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Watanabe, Yoshiyuki; Weimar, Timo; Kazui, Toshinobu et al. (2014) Epicardial ablation performance of a novel radiofrequency device on the beating heart in pigs. Ann Thorac Surg 97:673-8
Kar, Julia; Knutsen, Andrew K; Cupps, Brian P et al. (2014) A validation of two-dimensional in vivo regional strain computed from displacement encoding with stimulated echoes (DENSE), in reference to tagged magnetic resonance imaging and studies in repeatability. Ann Biomed Eng 42:541-54
Lawrance, Christopher P; Henn, Matthew C; Miller, Jacob R et al. (2014) Comparison of the stand-alone Cox-Maze IV procedure to the concomitant Cox-Maze IV and mitral valve procedure for atrial fibrillation. Ann Cardiothorac Surg 3:55-61
Miller, Jacob R; Eghtesady, Pirooz (2014) Ventricular assist device use in congenital heart disease with a comparison to heart transplant. J Comp Eff Res 3:533-46
Robertson, Jason O; Lee, Anson M; Voeller, Rochus K et al. (2014) Quantification of the functional consequences of atrial fibrillation and surgical ablation on the left atrium using cardiac magnetic resonance imaging. Eur J Cardiothorac Surg 46:720-8
Lawrance, Christopher P; Henn, Matthew C; Miller, Jacob R et al. (2014) A minimally invasive Cox maze IV procedure is as effective as sternotomy while decreasing major morbidity and hospital stay. J Thorac Cardiovasc Surg 148:955-61; discussion 962-2
Janjua, M Burhan; Makepeace, Carol M; Anastacio, Melissa M et al. (2014) Cardioprotective benefits of adenosine triphosphate-sensitive potassium channel opener diazoxide are lost with administration after the onset of stress in mouse and human myocytes. J Am Coll Surg 219:803-13
Saint, Lindsey L; Lawrance, Christopher P; Leidenfrost, Jeremy E et al. (2014) How I do it: minimally invasive Cox-Maze IV procedure. Ann Cardiothorac Surg 3:117-9
Saint, Lindsey L; Lawrance, Christopher P; Okada, Shoichi et al. (2013) Performance of a novel bipolar/monopolar radiofrequency ablation device on the beating heart in an acute porcine model. Innovations (Phila) 8:276-83
Weimar, Timo; Watanabe, Yoshiyuki; Kazui, Toshinobu et al. (2013) Impact of differential right-to-left shunting on systemic perfusion in pulmonary arterial hypertension. Catheter Cardiovasc Interv 81:888-95

Showing the most recent 10 out of 53 publications