This is a competitive renewal for a third term of the Vascular Biology and Hypertension Post-Doctoral Training Grant enabling both M.D. and Ph.D. fellows to study the vascular biology, signaling cascades, ionic currents and molecular events leading to systemic cardiovascular pathologies, such as hypertension, coronary artery disease (CAD), etc., supervised by NIH-funded mentors.
The specific aims of the program are: 1) to provide outstanding research training to fellows in various disciplines, in the areas of vascular biology, cell signaling and pathologic states, which lead to pathological events, including hypertension, stroke, CAD and other cardiovascular anomalies;2) to prepare trainees for careers as physicians and/or research scientists in biomedical research either as a primary career pursuit or in conjunction with clinical practice;and 3) to increase the number of M.D./D.O. trainees who pursue careers in academic medicine associated with translation of research findings into clinical practice. Skill sets will focus on a fundamental understanding of genetics, molecular biology, analytical chemistry, vascular biology, and whole animal physiology. Trainees will be taught the usefulness of animal models and in-vitro techniques for determining mechanisms of action of vascular and cardiac muscle cell activation. Techniques for measurements of blood flow, including radiographic, digital x-ray, fMRI, laser dopier, and confocal microscopy will be taught. The essentials of free-radical biology and generation of reactive oxygen species also will be taught. There will be increased efforts to allow trainees to translate the basic findings obtained in the research labs into clinical applications. The program has trained 5 M.D.s and 6 Ph.D.s over the past 4 years, with 4 fellows still in the program. Typically the number of applicants exceeds the number of available slots;however, our recent experience has been that following the match process, there is increasing matriculation to other institutions, usually leaving us with 6 fellows enrolled at any one time. We also attempt to always have one slot available for exceptional fellows who apply late. The quality of training is expected to be outstanding given our ability to recruit 29 NIH-funded mentors into the program. We also have direct access to the T35 Training Program, allowing us to introduce beginning medical student trainees to physician scientists at the end of their training who are about to enter medical specialties. These graduating trainees thus become role models.
|Malik, Mobin; Suboc, Tisha M; Tyagi, Sudhi et al. (2018) Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. Circ Res 123:1091-1102|
|Beyer, Andreas M; Freed, Julie K; Durand, Matthew J et al. (2016) Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res 118:856-66|
|Durand, Matthew J; Zinkevich, Natalya S; Riedel, Michael et al. (2016) Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. Arterioscler Thromb Vasc Biol 36:1254-62|
|Durand, Matthew J; Dharmashankar, Kodlipet; Bian, Jing-Tan et al. (2015) Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults. Hypertension 65:140-5|
|Meléndez, Giselle C; Manteufel, Edward J; Dehlin, Heather M et al. (2015) Non-human primate and rat cardiac fibroblasts show similar extracellular matrix-related and cellular adhesion gene responses to substance P. Heart Lung Circ 24:395-403|
|Mohandas, Appesh; Suboc, Tisha B; Wang, Jingli et al. (2015) Mineralocorticoid exposure and receptor activity modulate microvascular endothelial function in African Americans with and without hypertension. Vasc Med 20:401-8|
|Abais-Battad, Justine M; Rudemiller, Nathan P; Mattson, David L (2015) Hypertension and immunity: mechanisms of T cell activation and pathways of hypertension. Curr Opin Nephrol Hypertens 24:470-4|
|Flister, Michael J; Endres, Bradley T; Rudemiller, Nathan et al. (2014) CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. Cancer Res 74:6419-29|
|Dehlin, Heather M; Levick, Scott P (2014) Substance P in heart failure: the good and the bad. Int J Cardiol 170:270-7|
|Beyer, Andreas M; Durand, Matthew J; Hockenberry, Joseph et al. (2014) An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol 307:H1587-93|
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