In this application we propose to continue our highly successful multidisciplinary post-doctoral training program in critical care outcomes research. The training program provides 2-3 years of research training in the areas of critical illness and acute organ dysfunction, with a focus on complex critical illness syndromes such as acute lung injury and sepsis. The academic home of our training program is the CRISMA Center, an interdisciplinary research center with over 30 extramurally funded faculty members, 40 research staff members, and multiple core facilities for administrative support, laboratory work, and data management. CRISMA post-doctoral scholars will train in one of five interrelated areas based on CRISMA?s five scientific programs: (a) immunobiology and the cellular basis for organ injury; (b) systems modelling and computational biology; (c) clinical epidemiology of critical illness; (d) critical care ethics and decision making; and (e) critical care organization and management. In this renewal application we have further strengthened our training program by expanding training opportunities in precision medicine, predictive analytics, implementation science, and decision science. Trainees partner with their principle trainer and their training group to develop structured, written career development plans. Training activities include intensive mentorship in the form of weekly meetings with primary mentors and monthly meetings with their mentorship teams; didactic education in the form of formal coursework in research methodology through the University of Pittsburgh Institute for Clinical Research Education, in most cases culminating in the attainment of a master?s degree; and experiential research in which trainees design, execute, and complete mentored research projects in their chosen area of study. In addition, trainees present and receive feedback on their ongoing work through participation in weekly research seminars; as well as receive interactive instruction in the responsible conduct of research in both formal and informal settings. The training environment is supported by numerous training and career development resources at the University of Pittsburgh, including tight integration with our University?s Clinical and Translational Research Institute. Overall, our training program is designed to create an innovative scientific workforce with the skills necessary to answer the most pressing research questions in the field of critical illness and acute cardiopulmonary disease.

Public Health Relevance

Over 4 million Americans are admitted to an intensive care unit each year, and mortality for critical illness syndromes such as acute lung injury and sepsis exceeds 25%. This training program will provide post-doctoral scholars with state-of-the-art, interdisciplinary training in critical care outcomes research spanning T2, T3, and T4 translation, creating a scientific workforce with the skills, experience, and training to design and execute research studies that will improve patient-centered outcomes for patients with critical illness and acute cardiopulmonary disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007820-21
Application #
9629772
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Kalantari, Roya
Project Start
1996-09-06
Project End
2024-05-31
Budget Start
2019-06-01
Budget End
2020-05-31
Support Year
21
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Jha, Ruchira Menka; Koleck, Theresa A; Puccio, Ava M et al. (2018) Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury. J Neurol Neurosurg Psychiatry 89:1152-1162
Prout, Andrew J; Talisa, Victor B; Carcillo, Joseph A et al. (2018) Children with Chronic Disease Bear the Highest Burden of Pediatric Sepsis. J Pediatr 199:194-199.e1
Morris, Alan H (2018) Human Cognitive Limitations. Broad, Consistent, Clinical Application of Physiological Principles Will Require Decision Support. Ann Am Thorac Soc 15:S53-S56
Pinsky, Michael R (2018) Cardiopulmonary Interactions: Physiologic Basis and Clinical Applications. Ann Am Thorac Soc 15:S45-S48
Evans, Idris V R; Phillips, Gary S; Alpern, Elizabeth R et al. (2018) Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis. JAMA 320:358-367
Scheunemann, Leslie P; Khalil, Ramy; Rajagopal, Padma S et al. (2018) Development and Pilot Testing of a Simulation to Study How Physicians Facilitate Surrogate Decision-Making Based on Critically Ill Patients' Values and Preferences. J Pain Symptom Manage :
Yoon, Joo H; Pinsky, Michael R (2018) Predicting adverse hemodynamic events in critically ill patients. Curr Opin Crit Care 24:196-203
Mahmood, Syed S; Pinsky, Michael R (2018) Heart-lung interactions during mechanical ventilation: the basics. Ann Transl Med 6:349
Kievlan, Daniel R; Zhang, Li A; Chang, Chung-Chou H et al. (2018) Evaluation of Repeated Quick Sepsis-Related Organ Failure Assessment Measurements Among Patients With Suspected Infection. Crit Care Med 46:1906-1913
Prout, Andrew J; Wolf, Michael S; Fink, Ericka L (2017) Translating biomarkers from research to clinical use in pediatric neurocritical care: focus on traumatic brain injury and cardiac arrest. Curr Opin Pediatr 29:272-279

Showing the most recent 10 out of 97 publications