This application requests funding for the third competitive renewal of a postdoctoral training program in Cardiovascular Diseases. The program is designed to provide opportunities for Cardiology, Surgical and Pediatrics-based physician-scientist trainees to become independent investigators in Cardiovascular research. Trainees will be exposed to a diverse group of faculty, ranging from junior faculty to full- professor, each well-funded, with outstanding training and publication records. Trainees are encouraged to choose co-mentors, to enhance their multi-disciplinary training. Faculty mentors will direct research training in four primary areas: 1) Vascular Biology including atherosclerosis, angiogenesis and stem cells;2) Cardiomyocyte biology, including ion channels, pharmacology and tissue- and biomedical-engineering, 3) Immunology and Genomics, including transplantation and disease markers, and 4) Translational, Outcomes and Clinical Research, including population disparity in cardiovascular diseases, access to cardiac care and selective therapy. Strong emphasis is given to training physician-scientists with broadly- based, interdisciplinary knowledge and unique skill sets, with a strong fundamental understanding of cardiovascular biology and physiology. The usual duration of the program is two years and depending upon the individual trainees'selected area of research focus may be extended to three years. Candidates are selected from a very large pool of outstanding applicants to our clinical training programs in Surgery, Cardiothoracic Surgery, Adult and Pediatric Cardiology, Neonatology and Pediatric Critical Care, as well as through direct applications to the training program. Special efforts are undertaken to enhance our recruitment of woman and minorities, in part through affiliation with Harlem Hospital's Surgical Residency program. The training program and the core departments have well-established cardiovascular seminar series and journal clubs, joint laboratory meetings and retreats that are designed to foster collaborations and interdisciplinary research. In addition, the training program itself sponsors an annual retreat, seminars and work-in-progress sessions to assess trainee progress. The training program has an efficient evaluation and feedback system to ensure appropriate training of our fellows. Throughout the program and afterwards, trainees are advised on research and career development, individually and through a mentoring program headed by an Associate Director for Trainee Development. The program is designed to take advantage of the many existing strengths of Columbia University, including the Irving Center for Clinical and Translational Research (CTSA), Mailman School of Public Health, Genome Center, Bioinformatics, Tissue and Biomedical Engineering and numerous basic science departments and strong clinical programs, as well as the established track record of research training of physician-scientists in this program for the past 15 years.

Public Health Relevance

The mission of this program is to continue successful training of outstanding independent cardiovascular physician-scientists, who will become academic leaders in the fields of Cardiology, Surgery and Pediatrics.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Cai, Bishuang; Thorp, Edward B; Doran, Amanda C et al. (2017) MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis. J Clin Invest 127:564-568
Boutin, C; Carpenter, D J (2017) Assessment of wetland/upland vegetation communities and evaluation of soil-plant contamination by polycyclic aromatic hydrocarbons and trace metals in regions near oil sands mining in Alberta. Sci Total Environ 576:829-839
See, Sarah B; Clerkin, Kevin J; Kennel, Peter J et al. (2017) Ventricular assist device elicits serum natural IgG that correlates with the development of primary graft dysfunction following heart transplantation. J Heart Lung Transplant 36:862-870
Clerkin, Kevin J; Topkara, Veli K; Demmer, Ryan T et al. (2017) Implantable Cardioverter-Defibrillators in Patients With a Continuous-Flow Left Ventricular Assist Device: An Analysis of the INTERMACS Registry. JACC Heart Fail 5:916-926
Hardy, Mark A; Furr, Allen; Barret, Juan P et al. (2017) The immunologic considerations in human head transplantation. Int J Surg 41:196-202
Christakopoulos, Georgios E; Christopoulos, Georgios; Karmpaliotis, Dimitri et al. (2017) Predictors of Excess Patient Radiation Exposure During Chronic Total Occlusion Coronary Intervention: Insights From a Contemporary Multicentre Registry. Can J Cardiol 33:478-484
Clerkin, Kevin J; See, Sarah B; Farr, Maryjane A et al. (2017) Comparative Assessment of Anti-HLA Antibodies Using Two Commercially Available Luminex-Based Assays. Transplant Direct 3:e218
Clerkin, Kevin J; Ali, Ziad A; Mancini, Donna M (2017) New developments for the detection and treatment of cardiac vasculopathy. Curr Opin Cardiol :
Kelly, Christopher R; Kirtane, Ajay J; Stant, Jennifer et al. (2017) An Updated Protocol for Evaluating Chest Pain and Managing Acute Coronary Syndromes. Crit Pathw Cardiol 16:7-14
Chatterjee, Debanjana; Moore, Carolina; Gao, Baoshan et al. (2017) Prevalence of polyreactive innate clones among graft--infiltrating B cells in human cardiac allograft vasculopathy. J Heart Lung Transplant :

Showing the most recent 10 out of 199 publications