This is a renewal application for a training program now in its 4th year designed to attract and train both predoctoral and postdoctoral investigators in basic investigation of cardiovascular and pulmonary biology, with the goal of preparing these scientists for research careers in these fields. As a program, we have been extremely successful at introducing both Ph.D. and M.D. trainees to state-of-the-art molecular and cellular techniques that are being used to define the molecular basis of inherited and congenital human cardiovascular and pulmonary diseases. This work is done within the context of a strong mentoring program designed to promote the investigative careers of both our clinical and basic science trainees. Our goal for the new funding period is to continue to draw upon our strong faculty to train new scientists for academic research careers in cardiovascular and pulmonary biology. The objectives are: (i) to provide an extended period of full-time, protected investigative training in a clinical or bench laboratory with an accomplished scientific mentor, (ii) to correlate basic developmental biology and physiology with clinically relevant cardiovascular and pulmonary defects, (iii) to provide financial support and facilities for laboratory investigation, and (iv) to guide the trainees' development so that after completion of training successful competition for independent funding is likely.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007873-10
Application #
7225586
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F3))
Program Officer
Commarato, Michael
Project Start
1998-07-10
Project End
2008-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
10
Fiscal Year
2007
Total Cost
$264,148
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Towe, Christopher T; White, Frances V; Grady, R Mark et al. (2018) Infants with Atypical Presentations of Alveolar Capillary Dysplasia with Misalignment of the Pulmonary Veins Who Underwent Bilateral Lung Transplantation. J Pediatr 194:158-164.e1
Panzer, Adam A; Regmi, Suk D; Cormier, DePorres et al. (2017) Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart. Sci Rep 7:46438
Akhirome, Ehiole; Walton, Nephi A; Nogee, Julie M et al. (2017) The Complex Genetic Basis of Congenital Heart Defects. Circ J 81:629-634
Buggio, Maurizio; Towe, Christopher; Annan, Anand et al. (2016) Pulmonary vasculature directed adenovirus increases epithelial lining fluid alpha-1 antitrypsin levels. J Gene Med 18:38-44
Jay, Patrick Y; Akhirome, Ehiole; Magnan, Rachel A et al. (2016) Transgenerational cardiology: One way to a baby's heart is through the mother. Mol Cell Endocrinol 435:94-102
Varga, Zoltan; Zhu, Wandi; Schubert, Angela R et al. (2015) Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations. Circ Arrhythm Electrophysiol 8:1228-39
Kasimova, Marina A; Zaydman, Mark A; Cui, Jianmin et al. (2015) PIP?-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6. Sci Rep 5:7474
Halabi, Carmen M; Broekelmann, Thomas J; Knutsen, Russell H et al. (2015) Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness. Am J Physiol Heart Circ Physiol 309:H1008-16
Towe, Christopher; Chester Ogborn, A; Ferkol, Thomas et al. (2015) Bronchiolitis obliterans syndrome is not specific for bronchiolitis obliterans in pediatric lung transplant. J Heart Lung Transplant 34:516-21
Schulkey, Claire E; Regmi, Suk D; Magnan, Rachel A et al. (2015) The maternal-age-associated risk of congenital heart disease is modifiable. Nature 520:230-3

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