The Center for Clinical Epidemiology and Biostatistics (CCEB), the Cardiovascular Institute (CVI), the Division of Cardiovascular Medicine DCM), and the Pulmonary, Allergy, and Critical Care Division (PACCD) of the University of Pennsylvania School of Medicine submit this request for the renewal of an innovative and successful research training program for post-doctoral training for clinicians in cardiovascular and pulmonary clinical research, specifically designed to strengthen the links among traditional epidemiology and clinical cardiovascular and pulmonary medicine. The objective of the program is to train physicians to be rigorous and independent academic investigators able to use the range of approaches available in epidemiology to address clinical research issues regarding the etiology, prognosis, prevention and early detection, treatment, clinical economics, technology assessment, medical decision making, and quality of patient care of cardiovascular or pulmonary disease. The two- to three-year training program consists of required courses in clinical epidemiology, research methodology, and biostatistics;a required course in cardiopulmonary epidemiology;elective courses;extensive independent readings;attendance at and participation in research seminars at the CCEB, CVI, DCM, and PACCD;plus the completion of an independent research project. Specifically, the program is designed to: (1) provide in-depth knowledge of the research techniques appropriate to clinical research;(2) provide research experience with mentors in clinical epidemiology and cardiovascular and pulmonary research;and (3) bring together faculty and fellows in the CCEB, CVI, DCM, and PACCD. Trainees matriculate in the Master of Science in Clinical Epidemiology (MSCE) degree program. Strengths of the ongoing program, Cardiology and Pulmonary Research Training, are the long history of successful research training programs in the CCEB, DCM, and PACCD;the newly created CVI;the collaborative links that have been forged among these programs;the comprehensive course offerings and research programs that are available to trainees;and an extensive set of experienced program directors and faculty preceptors with successful training records. In addition, the availability of the broad range of rich expertise of the faculties in the-CCEB, DCM, CVI, and PACCD;numerous existing large databases available to these groups that can be used for research projects and training;a broad array of specialized analytic capabilities available for clinical studies (e.g., clinical trials, case-control, cohort research, etc.);and the faculties'commitment to collaborative research and training, combine to provide an ideal environment for this training program.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHL1-CSR-J (F1))
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Einhorn, Paula
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University of Pennsylvania
Biostatistics & Other Math Sci
Schools of Medicine
United States
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Porteous, Mary K; Lee, James C; Lederer, David J et al. (2017) Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension. Ann Am Thorac Soc 14:1514-1522
Hysinger, Erik B; Friedman, Nicholas L; Padula, Michael A et al. (2017) Tracheobronchomalacia Is Associated with Increased Morbidity in Bronchopulmonary Dysplasia. Ann Am Thorac Soc :
Kohn, Rachel; Madden, Vanessa; Kahn, Jeremy M et al. (2017) Diffusion of Evidence-based Intensive Care Unit Organizational Practices. A State-Wide Analysis. Ann Am Thorac Soc 14:254-261
Jones, Tiffanie K; Meyer, Nuala J (2017) What's in a Number? Platelet Count Dynamics as a Novel Mediator of Acute Respiratory Distress Syndrome Survival. Am J Respir Crit Care Med 195:1285-1287
Porteous, Mary K; Ky, Bonnie; Kirkpatrick, James N et al. (2016) Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction after Lung Transplant. Am J Respir Crit Care Med 193:1392-400
Baston, Cameron; West, T Eoin (2016) Lung ultrasound in acute respiratory distress syndrome and beyond. J Thorac Dis 8:E1763-E1766
Palakshappa, Jessica A; Christie, Jason D (2016) Survivorship Research: Studying the Past to Define the Future. Crit Care Med 44:1422-3
Porteous, Mary K; Rivera-Lebron, Belinda N; Kreider, Maryl et al. (2016) Determinants of 6-minute walk distance in patients with idiopathic pulmonary fibrosis undergoing lung transplant evaluation. Pulm Circ 6:30-6
Bakhru, Rita N; McWilliams, David J; Wiebe, Douglas J et al. (2016) Intensive Care Unit Structure Variation and Implications for Early Mobilization Practices. An International Survey. Ann Am Thorac Soc 13:1527-37
Kohn, Rachel; Halpern, Scott D; Kerlin, Meeta Prasad (2016) The implications of intensive care unit capacity strain for the care of critically ill patients. Rev Bras Ter Intensiva 28:366-368

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