This is a revised competitive renewal of NIH T32HL-07910 undid since 1999.
The aim i s to continue training the next generation of scientists in the clinically-relevant medical area of gene transfer for effective modulation of normal cell growth, and gene therapy. We request 4 pre- and 5 postdoctoral positions and 1 short term pre-doc slot for a minority student. Pre- and post-doctoral trainees will be trained 3-4 and 2-3 years, respectively. We assembled an outstanding group of 24 productive/interactive investigators from 8 departments of the medical school (Microbiology/Immunology, Biochemistry/Molecular Biology, Pharmacology/Toxicology, Medical/ Mol-cular Genetics, Medicine, Pediatrics, General Surgery and Urology) who have trained pre- and/or post-doctorals with multidisciplinary approaches using different cell types. Training emphasis is on hematopoietic stem (HSC) cells and blood cells, but includes studies with other cell types for gene modification to enhance collaboration/training experiences. The PI studies HSC, hematopoietic, and gene replacement, published >640 papers ,is on numerous editorial boards/NIH/other review/advisory committees, is cun'ent Pres-Elect of ASH, trained 66 pre/post docs. The Co-PI is recognized in the gene therapy and viral vector production area, has published >100 refereed papers in these areas, is Pres-Elect of ASGT, has trained >10 students/fellows. The PI/Co-PI are part of a long-term funded PPG on gene therapy along with 6 other preceptors on the program, and the program includes a nationally- recognized and funded clinical grade gene vector production facility. Our preceptors have extensive collaboration , co-publish with each other, have all labs within 5-10 minute walking distance and are dedicated to training students in gene transfer/therapy. Training entails one-on-one interactions, formal committee meetings, lab meetings, special seminar series, didactic courses, ethical training and scientific meeting presentations. An Internal and External Advisory Committee will monitor student/mentor progress. Our past students are employed in academia, and biotech and pharmaceutical companies. This training will enhance the future of gene transfer/therapy for basic understanding and treatment of disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Indiana University-Purdue University at Indianapolis
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Knab, Vanessa M; Corbin, Braden; Andrukhova, Olena et al. (2017) Acute Parathyroid Hormone Injection Increases C-Terminal but Not Intact Fibroblast Growth Factor 23 Levels. Endocrinology 158:1130-1139
Clinkenbeard, Erica L; Hanudel, Mark R; Stayrook, Keith R et al. (2017) Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow. Haematologica 102:e427-e430
Varberg, Kaela M; Winfree, Seth; Chu, Chenghao et al. (2017) Kinetic analyses of vasculogenesis inform mechanistic studies. Am J Physiol Cell Physiol 312:C446-C458
Hum, Julia M; Clinkenbeard, Erica L; Ip, Colin et al. (2017) The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1? expression. Bone Rep 6:38-43
Ocaña, Gail J; Pérez, Liliana; Guindon, Lynette et al. (2017) Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90?. Immunology 151:198-210
Sierra Potchanant, Elizabeth A; Cerabona, Donna; Sater, Zahi Abdul et al. (2017) INPP5E Preserves Genomic Stability through Regulation of Mitosis. Mol Cell Biol 37:
Serezani, Ana P M; Bozdogan, Gunseli; Sehra, Sarita et al. (2017) IL-4 impairs wound healing potential in the skin by repressing fibronectin expression. J Allergy Clin Immunol 139:142-151.e5
Gohn, Cassandra R; Blue, Emily K; Sheehan, BreAnn M et al. (2017) Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus. J Cell Physiol 232:1885-1892
Hum, Julia M; O'Bryan, Linda M; Tatiparthi, Arun K et al. (2017) Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho. J Am Soc Nephrol 28:1162-1174
Amin, Arpit; Zhurov, Yuriy; Ibrahim, George et al. (2016) Combined Endoscopic and Laparoscopic Management of Postcholecystectomy Mirizzi Syndrome from a Remnant Cystic Duct Stone: Case Report and Review of the Literature. Case Rep Surg 2016:1896368

Showing the most recent 10 out of 104 publications