This is a revised competitive renewal of NIH T32HL-07910 undid since 1999.
The aim i s to continue training the next generation of scientists in the clinically-relevant medical area of gene transfer for effective modulation of normal cell growth, and gene therapy. We request 4 pre- and 5 postdoctoral positions and 1 short term pre-doc slot for a minority student. Pre- and post-doctoral trainees will be trained 3-4 and 2-3 years, respectively. We assembled an outstanding group of 24 productive/interactive investigators from 8 departments of the medical school (Microbiology/Immunology, Biochemistry/Molecular Biology, Pharmacology/Toxicology, Medical/ Mol-cular Genetics, Medicine, Pediatrics, General Surgery and Urology) who have trained pre- and/or post-doctorals with multidisciplinary approaches using different cell types. Training emphasis is on hematopoietic stem (HSC) cells and blood cells, but includes studies with other cell types for gene modification to enhance collaboration/training experiences. The PI studies HSC, hematopoietic, and gene replacement, published >640 papers ,is on numerous editorial boards/NIH/other review/advisory committees, is cun'ent Pres-Elect of ASH, trained 66 pre/post docs. The Co-PI is recognized in the gene therapy and viral vector production area, has published >100 refereed papers in these areas, is Pres-Elect of ASGT, has trained >10 students/fellows. The PI/Co-PI are part of a long-term funded PPG on gene therapy along with 6 other preceptors on the program, and the program includes a nationally- recognized and funded clinical grade gene vector production facility. Our preceptors have extensive collaboration , co-publish with each other, have all labs within 5-10 minute walking distance and are dedicated to training students in gene transfer/therapy. Training entails one-on-one interactions, formal committee meetings, lab meetings, special seminar series, didactic courses, ethical training and scientific meeting presentations. An Internal and External Advisory Committee will monitor student/mentor progress. Our past students are employed in academia, and biotech and pharmaceutical companies. This training will enhance the future of gene transfer/therapy for basic understanding and treatment of disease.
|White, Kenneth E; Hum, Julia M; Econs, Michael J (2014) Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis. Curr Osteoporos Rep 12:252-62|
|Pham, Duy; Sehra, Sarita; Sun, Xin et al. (2014) The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation. J Allergy Clin Immunol 134:204-14|
|Walline, Crystal C; Deffit, Sarah N; Wang, Nan et al. (2014) Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. Immunology 141:531-9|
|Glosson-Byers, Nicole L; Sehra, Sarita; Stritesky, Gretta L et al. (2014) Th17 cells demonstrate stable cytokine production in a proallergic environment. J Immunol 193:2631-40|
|Pham, Duy; Walline, Crystal C; Hollister, Kristin et al. (2013) The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor * chain. J Biol Chem 288:27423-33|
|Chitteti, Brahmananda Reddy; Bethel, Monique; Voytik-Harbin, Sherry L et al. (2013) In vitro construction of 2D and 3D simulations of the murine hematopoietic niche. Methods Mol Biol 1035:43-56|
|Hua, Laiqing; Yao, Shuyu; Pham, Duy et al. (2013) Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection. J Virol 87:11884-93|
|Hollister, Kristin; Kusam, Saritha; Wu, Hao et al. (2013) Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model. J Immunol 191:3705-11|
|Pham, Duy; Yu, Qing; Walline, Crystal C et al. (2013) Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. J Immunol 191:902-11|
|Martin, Holly; Mali, Raghuveer Singh; Ma, Peilin et al. (2013) Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest 123:4449-63|
Showing the most recent 10 out of 61 publications