This application is for a competing renewal in the Cardiovascular Pathophysiology training program at UAB for pre-doctoral students which is currently in its 9th year. We have successfully recruited a significant proportion of minorities, MD/Ph.D students and women trainees. Since the appointment of the first trainees in late 1999 24 students have entered the training program with 16 having completed their graduate studies and developed science related careers in respected national research centers and universities. The training will be undertaken by faculty from six separate departments at the institution (four basic science and two clinical) with a expertise in a broad range of research areas relevant to cardiovascular research. This training program recognizes the integrated and multi-disciplinary nature of modern cardiovascular research and includes faculty from six research centers at UAB encompassing institutional areas of strength in Free Radical Biology, Nephrology Research, Clinical Nutrition, BioMatrix Engineering and Regenerative Medicine Comprehensive Diabetes and Hypertension. The students will earn degrees in the graduate programs in pathology, physiology or integrated biomedical sciences (IBS). Students supported by the proposal will have completed the first year, selected a project and mentor with cardiovascular relevance and demonstrated excellence in their studies and research potential. The program plan consists of a didactic component that emphasizes cardiovascular disease in the context of other pathologies with particular emphasis on molecular mechanisms of disease. An area of increasing significance in cardiovascular research and a strength at UAB. We also include courses that encompass career enhancement components including preparation for research applications, review of papers, and preparation of review articles. In addition we have included an emerging and important area in graduate education in the development of the management and personnel skills necessary to direct a research group. No overlap with current training programs at this institution exist.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007918-15
Application #
8494661
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
15
Fiscal Year
2013
Total Cost
$142,588
Indirect Cost
$13,263
Name
University of Alabama Birmingham
Department
Pathology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Krzywanski, David M; Moellering, Douglas R; Westbrook, David G et al. (2016) Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry. Circ Cardiovasc Genet 9:26-36
Alexander, Grant C; Vines, Jeremy B; Hwang, Patrick et al. (2016) Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo. ACS Appl Mater Interfaces 8:5178-87
Kesterson, Robert A; Johnson, Larry W; Lambert, Laura J et al. (2016) Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer. Bio Protoc 6:
Giordano, Samantha; Hage, Fadi G; Xing, Dongqi et al. (2015) Estrogen and Cardiovascular Disease: Is Timing Everything? Am J Med Sci 350:27-35
Black, Leland L; Srivastava, Roshni; Schoeb, Trenton R et al. (2015) Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice. J Immunol 195:4685-98
Oh, Joo-Yeun; Stapley, Ryan; Harper, Victoria et al. (2015) Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements. Transfusion 55:2967-78
Wall, S B; Oh, J-Y; Mitchell, L et al. (2015) Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. Redox Biol 4:346-54
Stapley, Ryan; Rodriguez, Cilina; Oh, Joo-Yeun et al. (2015) Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage. Free Radic Biol Med 85:207-18
El-Ferzli, George T; Andukuri, Adinarayana; Alexander, Grant et al. (2015) A Nitric Oxide-Releasing Self-Assembled Peptide Amphiphile Nanomatrix for Improving the Biocompatibility of Microporous Hollow Fibers. ASAIO J 61:589-95
Kramer, Philip A; Prichard, Lynn; Chacko, Balu et al. (2015) Inhibition of the lymphocyte metabolic switch by the oxidative burst of human neutrophils. Clin Sci (Lond) 129:489-504

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