This application requests continuing support for Years 11-15 for the Training Program in Translational Cardiovascular Science within the University of Wisconsin Cardiovascular Research Center (CVRC) at the University of Wisconsin-Madison. Housed in the School of Medicine and Public Health (SMPH), the CVRC is a campus-wide interdisciplinary research center with faculty members from seven additional schools and colleges and from 27 academic departments. All are dedicated to developing programs in basic research, clinical investigation, diagnosis and therapy, and/or public education concerning the basis for cardiovascular diseases. The training program provides basic research training for postdoctoral MD's and PhD's (four positions), as well as predoctoral trainees (four positions, with a request for one additional slot), with the goal of training scientists who will be capable of thinking and working "from molecule to bedside." The practical immediate aims are to attract and train clinicians in basic research, and to attract and train graduate and postdoctoral (PhD) students in clinically motivated basic science. This application requests support for research training of physicians as part of their resident and fellow training. The training program also funds predoctoral and postdoctoral (PhD) trainees in translational cardiovascular sciences. The 24 trainers in this program have been selected from members of the CVRC for the clinical relevance of their science in the focus areas (contractility/heart failure, ion channels/arrhythmias and vascular biology/atherosclerosis and cell biology/stem cells), their training records, and the overall activity and impact of their peer-reviewed research programs. Training takes place at UW-Madison and takes advantage of the strong institutional support and environment for such training, as well as the established working relationships between clinical and basic science departments and faculty both within the School of Medicine and Public Health and the University at large. Trainers and trainees all participate in core activities that define the program as a cohesive entity. The scientists and physician scientists trained in this translational cardiovascular science program are in unique positions to apply basic scientific knowledge to benefit patients with cardiovascular disease, the foremost cause of mortality among Americans.

Public Health Relevance

Translational cardiovascular research training is a much needed and important initiative because, despite considerable progress in cardiovascular research, cardiovascular disease is still the leading cause of death of adult men and women in our nation. This program brings together basic and clinical researchers and trainees with the goal of training physician-scientists who will be capable of thinking and working from molecule to bedside, which is a fundamental avenue for approaching this important training for the future.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007936-13
Application #
8495387
Study Section
Special Emphasis Panel (ZHL1-CSR-M (O1))
Program Officer
Carlson, Drew E
Project Start
2000-07-01
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
13
Fiscal Year
2013
Total Cost
$450,750
Indirect Cost
$28,762
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Stern, Rebecca; Tattersall, Matthew C; Gepner, Adam D et al. (2015) Sex differences in predictors of longitudinal changes in carotid artery stiffness: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 35:478-84
Belair, David G; Khalil, Andrew S; Miller, Michael J et al. (2014) Serum-dependence of affinity-mediated VEGF release from biomimetic microspheres. Biomacromolecules 15:2038-48
Rodriguez, Karien J; Piechura, Laura M; Porras, Ana M et al. (2014) Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification. BMC Cardiovasc Disord 14:29
Chowdhury, Sandipan; Jarecki, Brian W; Chanda, Baron (2014) A molecular framework for temperature-dependent gating of ion channels. Cell 158:1148-58
Gepner, Adam D; Korcarz, Claudia E; Colangelo, Laura A et al. (2014) Longitudinal effects of a decade of aging on carotid artery stiffness: the multiethnic study of atherosclerosis. Stroke 45:48-53
Tattersall, Matthew C; Gassett, Amanda; Korcarz, Claudia E et al. (2014) Predictors of carotid thickness and plaque progression during a decade: the Multi-Ethnic Study of Atherosclerosis. Stroke 45:3257-62
Oelstrom, Kevin; Goldschen-Ohm, Marcel P; Holmgren, Miguel et al. (2014) Evolutionarily conserved intracellular gate of voltage-dependent sodium channels. Nat Commun 5:3420
Gunnarsson, Sverrir I; Peppard, Paul E; Korcarz, Claudia E et al. (2014) Obstructive sleep apnea is associated with future subclinical carotid artery disease: thirteen-year follow-up from the Wisconsin sleep cohort. Arterioscler Thromb Vasc Biol 34:2338-42
Kalscheur, Matthew M; Vaidyanathan, Ravi; Orland, Kate M et al. (2014) KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia. Heart Rhythm 11:885-94
Gepner, Adam D; Colangelo, Laura A; Blondon, Marc et al. (2014) 25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 34:1102-9

Showing the most recent 10 out of 82 publications