This proposal for a training program in the area of sleep and its disorders. There is growing evidence of the prevalence of sleep disorders in the American population, and that problems related to inadequate sleep have a major impact on many aspects of our society. At a basic level, little is known about the fundamental mechanisms that control sleep and the function(s) of sleep. Thus, there is a major opportunity for scientific discovery. One of the barriers that is recognized to advancing the knowledge base in this area is the paucity of investigators, both those engaged in basic research and in patient-oriented research. This application describes a training program that is based on the relatively unique faculty resources and structure at the University of Pennsylvania for support of research in sleep and its disorders (the Center for Sleep and Respiratory Neurobiology). The proposal describes four specific training aspects that are intended to complete the matrix for training opportunities at the University of Pennsylvania in the area of research in sleep/sleep disorders. These four aspects are the following: a) a graduate program in neurobiology of sleep and circadian rhythm. This will be based on the highly successful and well developed Neuroscience Graduate Program. We will utilize, where appropriate, structures, courses and other resources developed by this group;b) a new graduate track in genomics/computational biology;c) a targeted MD/PhD program to train physician-scientists in sleep research. This aspect of our program will be based on the outstanding institutional MD/PhD program at the University of Pennsylvania;and d) a postdoctoral training program for nurse investigators. This will be based on the preeminent School of Nursing at the University of Pennsylvania. There are members of the tenured 'faculty at the School who are funded investigators in outcomes of sleep disorders. This, together with the other rich intellectual resources at the School of Nursing, provides a unique opportunity to develop a much needed national program to train nurse investigators in this area. All of these components of the program will utilize the extensive resources for research that have been developed by the Center for Sleep at the University of Pennsylvania.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Tigno, Xenia
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University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
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Han, Bo; McCarren, Hilary S; O'Neill, Dan et al. (2014) Distinctive recruitment of endogenous sleep-promoting neurons by volatile anesthetics and a nonimmobilizer. Anesthesiology 121:999-1009
Cielo, Christopher M; Silvestre, Jason; Paliga, J Thomas et al. (2014) Utility of screening for obstructive sleep apnea syndrome in children with craniofacial disorders. Plast Reconstr Surg 134:434e-441e
Trojanowski, Nicholas F; Padovan-Merhar, Olivia; Raizen, David M et al. (2014) Neural and genetic degeneracy underlies Caenorhabditis elegans feeding behavior. J Neurophysiol 112:951-61
Lynch, Jennifer M; Buckley, Erin M; Schwab, Peter J et al. (2014) Noninvasive optical quantification of cerebral venous oxygen saturation in humans. Acad Radiol 21:162-7
Prince, Toni-Moi; Wimmer, Mathieu; Choi, Jennifer et al. (2014) Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory. Neurobiol Learn Mem 109:122-30
Zhang, Ray; Lahens, Nicholas F; Ballance, Heather I et al. (2014) A circadian gene expression atlas in mammals: implications for biology and medicine. Proc Natl Acad Sci U S A 111:16219-24
Wester, Jason C; Contreras, Diego (2013) Differential modulation of spontaneous and evoked thalamocortical network activity by acetylcholine level in vitro. J Neurosci 33:17951-66
Nelson, M D; Trojanowski, N F; George-Raizen, J B et al. (2013) The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans. Nat Commun 4:2846
Nall, Aleksandra H; Sehgal, Amita (2013) Small-molecule screen in adult Drosophila identifies VMAT as a regulator of sleep. J Neurosci 33:8534-40
Dean, Grace E; Redeker, Nancy S; Wang, Ya-Jung et al. (2013) Sleep, mood, and quality of life in patients receiving treatment for lung cancer. Oncol Nurs Forum 40:441-51

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