This amended competing renewal HL07954 """"""""Multidisciplinary Training in Cardiovascular Biology"""""""" is centered in the Institute for Medicine and Engineering (IME) at the University of Pennsylvania. The IME bridges the School of Medicine (SOM) to the physical, engineering and computational sciences principally in the School of Engineering (SEAS). The Institute's modern research labs and core laboratory facilities are adjacent to both SOM and SEAS. The grant renewal will support 6 pre- and 6 postdoctoral trainees in interdisciplinary cardiovascular pathophysiology including at least one Clinical Fellow. 27 well-funded training faculty (IME members), representing 14 departments distributed across Penn's SOM, Children's Hospital of Philadelphia, and SEAS, conduct basic and/or translational-clinical Cardiovascular research. Considerable institutional infrastructural support from both Schools is committed to the program. Complementary hypothesis-driven and design-driven-discovery approaches to CV research are integrated to across a full spectrum of scales from the molecular to in vivo. Strong critical metrics for the current funding cycle (i.e. since 2005), include: (i) successful graduation and advancement of PhD students and post-Postdoc employment, and (il) trainee authorship of 124 papers in leading journals. Two Clinical/Translational Fellows (MDs) who were supported with commitment of >80% research time, published 18 papers. Trainee support is for two years to ensure a''vigorous, vital program. Trainees are selected in competitive review by a Steering Committee on the basis of academic record, quality of research abilities, and commitment to research in interdisciplinary cardiovascubiology. An External Advisory Committee reviews the program biennially. A substantial formal program for postdoctoral career development is provided. Predoctoral trainees are registered in one of the Graduate Groups of SOM or of SEAS allied to SOM. Predoctoral trainees complete at least one, and usually several, courses in cardiovascular-related engineering. Participation is mandatory in the benchmark Interdisciplinary Seminar Series (>40 lectures/year) and biweekly Chalk Talks. Minority (3 of 11) and Women representation (6of 11) is strong.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007954-14
Application #
8469540
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
1994-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
14
Fiscal Year
2013
Total Cost
$615,358
Indirect Cost
$38,523
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Yu, Christopher K; Xu, Tina; Assoian, Richard K et al. (2018) Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators. Arterioscler Thromb Vasc Biol 38:164-173
Driesbaugh, Kathryn H; Branchetti, Emanuela; Grau, Juan B et al. (2018) Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation. J Mol Cell Cardiol 115:94-103
Cao, Wen; Chang, Yulin V; Englund, Erin K et al. (2018) High-speed whole-brain oximetry by golden-angle radial MRI. Magn Reson Med 79:217-223
Child, Daniel D; Lee, John H; Pascua, Christine J et al. (2018) Cardiac mTORC1 Dysregulation Impacts Stress Adaptation and Survival in Huntington's Disease. Cell Rep 23:1020-1033
Khoshnejad, Makan; Brenner, Jacob S; Motley, William et al. (2018) Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9. Sci Rep 8:1760
Lee, Hyunyeol; Englund, Erin K; Wehrli, Felix W (2018) Interleaved quantitative BOLD: Combining extravascular R2' - and intravascular R2-measurements for estimation of deoxygenated blood volume and hemoglobin oxygen saturation. Neuroimage 174:420-431
Brenner, Jacob S; Kiseleva, Raisa Yu; Glassman, Patrick M et al. (2018) The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series). Pulm Circ 8:2045893217752329
Englund, Erin K; Rodgers, Zachary B; Langham, Michael C et al. (2018) Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption. Magn Reson Med 79:846-855
Chen, Jason; Verni, Christopher C; Jouppila, Annukka et al. (2018) Dual antiplatelet and anticoagulant (APAC) heparin proteoglycan mimetic with shear-dependent effects on platelet-collagen binding and thrombin generation. Thromb Res 169:143-151
Lynch, Jennifer M; Ko, Tiffany; Busch, David R et al. (2018) Preoperative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease. J Thorac Cardiovasc Surg 156:1657-1664

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