Research in vascular biology has been responsible for remarkable changes in how we prevent, monitor and treat cardiovascular disease. The last fifty years have witnessed a transformation in patient care, increase in life expectancy and improvement in the quality of lives of those afflicted with vascular problems. It is through training of the next generation that we have made these achievements and it is through training that we will continue to make additional improvements in prevention and health care. The present application request funds to continue the interdisciplinary training of graduate students and post-doctoral fellows in vascular biology. In particular we aim at developing scientists who can: (1) "speak" various languages (metabolomics, pathology, molecular biology, genomics, and biomathematics), (2) integrate information and think towards (3) solving real clinical problems. To achieve these goals we have developed a multi-mentorship approach, novel didactic components and incorporated an interactive exposure to medicine into the structure of the training. UCLA houses a tremendous resource of interdisciplinary groups whose research focuses in vascular biology. The group includes 27 laboratories that currently offer training to 124 graduate students and post-doctoral fellows. It is this community that constitutes the pillars of a unique training program for the next generation of investigators in vascular biology. Being the only Vascular Biology Training grant in Los Angeles and one in four in California, we have trained 28 graduate students and post-doctoral fellows since 2002. These have produced 101 peer-reviewed publications while in the program and 9 have progressed to develop independent research groups in industry and universities across the nation. Furthermore, the activities associated with the training program have catalyzed interactions between groups intensifying collaborative activities. On the average 10 peer reviewed publications show the participation of two or more laboratories each year. Here, we request funding for 7 pre and 3 post-doctoral fellows / year, in which 2-3 new graduate students and either 1 or 2 post-doctoral fellows will enter the program each year. It is also our goal to actively seek and promote training and engagement of underrepresented minority groups (since 2002 we have a 21% minority trainee representation). It is an important objective of this program to be at the forefront of innovation in vascular biology education with strong emphasis in research integrity and ethics. In this current renewal we proposed the implementation of several new strategies to attain these goals and further improve the participation of minorities and the quality of training in vascular research. The success of this training program has engendered enthusiasm by the School of Medicine, College of Letters and Sciences and the Graduate Division at UCLA all of which have committed to provide additional institutional support towards activities developed by the VBTP.
Diseases that affect blood vessels continue to be the number one killer in Western societies. This application is relevant because it proposes unique, comprehensive and interdisciplinary training to the next generation of vascular biologists. It is our objective to produce individuals that will lead our next steps towards solving current and future medical problems in vascular disease.
|Rau, Christoph D; Wang, Jessica; Avetisyan, Rozeta et al. (2015) Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circ Cardiovasc Genet 8:40-9|
|Goddard, Lauren M; Murphy, Thomas J; Org, Tönis et al. (2014) Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell 156:549-62|
|Warren, Carmen M; Ziyad, Safiyyah; Briot, Anaïs et al. (2014) A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Sci Signal 7:ra1|
|Civelek, Mete; Lusis, Aldons J (2014) Systems genetics approaches to understand complex traits. Nat Rev Genet 15:34-48|
|Valenzuela, Nicole M; McNamara, Jeffrey T; Reed, Elaine F (2014) Antibody-mediated graft injury: complement-dependent and complement-independent mechanisms. Curr Opin Organ Transplant 19:33-40|
|Emert, Benjamin; Hasin-Brumshtein, Yehudit; Springstead, James R et al. (2014) HDL inhibits the effects of oxidized phospholipids on endothelial cell gene expression via multiple mechanisms. J Lipid Res 55:1678-1692|
|Gluck, Jessica M; Delman, Connor; Chyu, Jennifer et al. (2014) Microenvironment influences vascular differentiation of murine cardiovascular progenitor cells. J Biomed Mater Res B Appl Biomater 102:1730-9|
|Chapski, Douglas J; Monte, Emma; Vondriska, Thomas M (2014) Positive feedback in cardioprotection: can more mechanism lead to translation? Circ Res 114:1225-7|
|Jin, Y-P; Valenzuela, N M; Ziegler, M E et al. (2014) Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus. Am J Transplant 14:806-19|
|Civelek, Mete; Lusis, Aldons J (2014) From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol 34:1809-10|
Showing the most recent 10 out of 64 publications