This is a competitive renewal application for a post-doctoral Cardiovascular Training Grant (CVTG) Program centered at Tufts Medical Center (Tufts-MC) and Tufts University School of Medicine (TUSM). This CVTG provides state-of-the-art training to outstanding postdoctoral M.D. and/or Ph.D. fellows and is exemplary of the approach that the NHLBI seeks for training the next generation of CV scientists. Two broad and overlapping types of mechanistic CV research are emphasized: (1) cellular and molecular investigations of the CV system;and (2) translational, clinical studies in CV medicine. In its first five-year cycle this CVTG Program has been highly successful with 20 trainees to date, 43 peer-reviewed articles published by trainees, and two CVTG graduates now with K-grant funding. Several integrated elements make this CVTG Program a highly unique, multidisciplinary training experience: the rich training environment of the Tufts Health Sciences Campus, which includes Tufts-MC, TUSM, the Tufts Sackler Graduate School of Biomedical Sciences and the Tufts Human Nutrition Research Center, the internationally recognized Molecular Cardiology Research Institute, a major CV research department at Tufts-MC with 17 Pis and ~100 people, and the Tufts-MC Cardiology Division, with a superb group of translational researchers;the extensive portfolio of NIH-funded CV research in CVTG faculty;new training resources from the recent CTSA award;and the world-class faculty, with highly evolved collaborative interactions especially in this CVTG Program. Additional important strengths of this revised CVTG application include: 1. a special emphasis on mentoring, with each trainee being mentored by a 3-member mentoring committee with expertise spanning basic, clinical, and translational approaches, 2. a strong commitment to recruitment of highly qualified minority trainees, and 3. the inclusion of a strong and broad core curriculum. Trainees and faculty are formally evaluated on an annual basis. This program trains 4 postdoctoral M.D. and/or Ph.D. fellows per year for three years (steady-state: 12 trainees/year), with the goal of producing independent cardiovascular scientists well-equipped to lead their own research programs.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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Tufts University
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Morine, Kevin J; Qiao, Xiaoying; York, Sam et al. (2018) Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure. Circulation 138:513-526
Upshaw, Jenica N; Konstam, Marvin A; Klaveren, David van et al. (2016) Multistate Model to Predict Heart Failure Hospitalizations and All-Cause Mortality in Outpatients With Heart Failure With Reduced Ejection Fraction: Model Derivation and External Validation. Circ Heart Fail 9:
Salvador, Ane M; Nevers, Tania; Velázquez, Francisco et al. (2016) Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure. J Am Heart Assoc 5:e003126
Zeiger, A S; Liu, F D; Durham, J T et al. (2016) Static mechanical strain induces capillary endothelial cell cycle re-entry and sprouting. Phys Biol 13:046006
Velázquez, Francisco; Grodecki-Pena, Anna; Knapp, Andrew et al. (2016) CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol 196:1305-1316
Paulus, Jessica K; Lai, Lana Y H; Lundquist, Christine et al. (2016) Field Synopsis of the Role of Sex in Stroke Prediction Models. J Am Heart Assoc 5:
Qin, Zhexue; Bagley, Jessamyn; Sukhova, Galina et al. (2015) Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3. J Mol Cell Cardiol 87:160-70
Wessler, Benjamin S; Udelson, James E (2015) Neuronal dysfunction and medical therapy in heart failure: can an imaging biomarker help to ""personalize"" therapy? J Nucl Med 56 Suppl 4:20S-24S
Wessler, Benjamin S; Kent, David M (2015) Prevention of recurrent stroke in patients with patent foramen ovale. Neurol Clin 33:491-500
Wessler, Benjamin S; Lai Yh, Lana; Kramer, Whitney et al. (2015) Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical Prediction Model Database. Circ Cardiovasc Qual Outcomes 8:368-75

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