The objective of the """"""""Multidisciplinary Training in Lung Biology"""""""" training grant is to produce outstanding, independent biomedical scientists who investigate the mechanisms, manifestations, preventions and cures for lung disorders. While the program is young, there is a solid track record of training/mentoring and extensive interactive collaborations between basic science and clinical faculty. This interdisciplinary program is to both predoctoral, where a Ph.D. program is completed in the graduate program of Cell and Molecular Biology and postdoctoral, where qualified M.D. or Ph.D. candidates are offered an advanced research experience. Training is mentor-based but is enriched by didactic courses and workshops in advanced contemporary laboratory skills coupled with """"""""survival skills"""""""" needed to excel in modem academia. Productive Mentor and trainee interactions are central to the research training experience and are supplemented by appropriate course work, active participation in conferences and presentations of original research at local and national scientific meetings. The participating faculty, were chosen based on research productivity, significant grant support, collegiality and commitment to serve as mentors. The identified focus areas include pulmonary mechanics, bioengineering, airway epithelial biology, pathology, oxidative chemistry, lung immunobiology, cell apotosis, cell signaling, lung injury and with emphasis on patient oriented research including lung mechanics, asthma, interstitial lung disease and acute lung injury (ARDS).The disciplines of physiology, pulmonary medicine, pathology and immunobiology are strongly represented. Trainee progress will be carefully evaluated and productively monitored by each mentor(s), the program director and executive committee. Progress is evaluated by an independent advisory committee: The strengths of the program lie in 1.) the multidisciplinary environment 2.) the strong interactions between the clinical and basic science faculty 3.) the training track record of the faculty and 4.) strong institutional support. We expect to train and prepare future productive leaders in pulmonary research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Colombini-Hatch, Sandra
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University of Vermont & St Agric College
Internal Medicine/Medicine
Schools of Medicine
United States
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Fenn, Spencer L; Miao, Tianxin; Scherrer, Ryan M et al. (2016) Dual-Cross-Linked Methacrylated Alginate Sub-Microspheres for Intracellular Chemotherapeutic Delivery. ACS Appl Mater Interfaces 8:17775-83
Randall, Matthew J; Haenen, Guido R M M; Bouwman, Freek G et al. (2016) The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase. Toxicol Lett 240:43-9
Ziegler, Christopher M; Eisenhauer, Philip; Bruce, Emily A et al. (2016) The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. PLoS Pathog 12:e1005501
Heppner, David E; Hristova, Milena; Dustin, Christopher M et al. (2016) The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling. J Biol Chem 291:23282-23293
Habibovic, Aida; Hristova, Milena; Heppner, David E et al. (2016) DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma. JCI Insight 1:e88811
Heppner, David E; van der Vliet, Albert (2016) Redox-dependent regulation of epidermal growth factor receptor signaling. Redox Biol 8:24-7
Luzader, Deborah H; Willsey, Graham G; Wargo, Matthew J et al. (2016) The Type Three Secretion System 2-Encoded Regulator EtrB Modulates Enterohemorrhagic Escherichia coli Virulence Gene Expression. Infect Immun 84:2555-65
Charron, Patrick N; Fenn, Spencer L; Poniz, Alex et al. (2016) Mechanical properties and failure analysis of visible light crosslinked alginate-based tissue sealants. J Mech Behav Biomed Mater 59:314-21
Little, A C; Sham, D; Hristova, M et al. (2016) DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties. Oncogenesis 5:e261
Ubags, Niki D J; Burg, Elianne; Antkowiak, Maryellen et al. (2016) A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function. Am J Respir Cell Mol Biol 55:188-200

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