We seek continued NIH support for our Training Program in cardiac imaging research. Funds are requested to support 8 fellows annually. Our program emphasizes the education of basic (PhD) and clinical (MD) scientists in modern cardiac magnetic resonance (MR), positron emission tomography (PET) and computed tomography (CT) imaging science. Our goal is to develop future leaders of cardiac imaging, emphasizing novel developmental and translational research. The training program, based in the MGH Cardiac MR-PET-CT Program, is a joint cardiology and radiology program, a model which greatly enhances opportunities for collaboration. The curriculum consists of didactic lectures including the clinical effectiveness course at the Harvard School of Public Health, laboratory exercises and individual research projects. A major strength of the Program is our outstanding faculty, each of whom are pursuing research at the cutting-edge of cardiac imaging science. The faculty consists of 21 MD and/or PhD scientists with expertise in cardiology, radiology, physics, computer science and outcomes research. Collectively they have over 50 active extramural grants and have supervised over 250 pre/post doctoral fellows in various aspects of basic and clinical cardiac imaging research. Extensive collaboration among the faculty, trainees, and accomplished investigators throughout the MGH, Harvard Medical School and MIT communities, further increase the Program's scientific impact. Broad exposure to highly motivated scientists and committed mentors, with an emphasis on individual scientific excellence, provide the conditions for the successful training of leaders in the use of these important technologies in cardiology. During the initial four years of NIH support, all NIH trainee positions were filled, and trainees authored or coauthored over 50 peer-reviewed publications. All finished trainees obtained staff positions in academic medical centers or continued in academic training programs. To enhance the program we have added technical faculty and novel equipment offering additional research opportunities for trainees in evolving areas of cardiac imaging science including FDG PET imaging of plaque activity, molecular imaging using optical and MR probes, 9.4T imaging of animal models, novel cardiac image reconstruction approaches and simultaneous imaging of stenosis and function during chemical stress using a dual source cardiac CT.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076136-10
Application #
8509762
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
2004-07-01
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
10
Fiscal Year
2013
Total Cost
$359,410
Indirect Cost
$24,956
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Lo, Janet; Lu, Michael T; Kim, Elli A et al. (2016) Statin Effects to Reduce Hepatosteatosis as Measured by Computed Tomography in Patients With Human Immunodeficiency Virus. Open Forum Infect Dis 3:ofw062
Pursnani, Amit; Celeng, Csilla; Schlett, Christopher L et al. (2016) Use of Coronary Computed Tomographic Angiography Findings to Modify Statin and Aspirin Prescription in Patients With Acute Chest Pain. Am J Cardiol 117:319-24
Lu, Michael T; Park, Jakob; Ghemigian, Khristine et al. (2016) Epicardial and paracardial adipose tissue volume and attenuation - Association with high-risk coronary plaque on computed tomographic angiography in the ROMICAT II trial. Atherosclerosis 251:47-54
Nou, Eric; Lu, Michael T; Looby, Sara E et al. (2016) Serum oxidized low-density lipoprotein decreases in response to statin therapy and relates independently to reductions in coronary plaque in patients with HIV. AIDS 30:583-90
Lu, Michael T; Onuma, Oyere K; Massaro, Joseph M et al. (2016) Lung Cancer Screening Eligibility in the Community: Cardiovascular Risk Factors, Coronary Artery Calcification, and Cardiovascular Events. Circulation 134:897-9
Pursnani, Amit; Lee, Ashley M; Mayrhofer, Thomas et al. (2015) Early resting myocardial computed tomography perfusion for the detection of acute coronary syndrome in patients with coronary artery disease. Circ Cardiovasc Imaging 8:e002404
Tawakol, Ahmed; Singh, Parmanand; Mojena, Marina et al. (2015) HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages. Arterioscler Thromb Vasc Biol 35:1463-71
Lo, Janet; Lu, Michael T; Ihenachor, Ezinne J et al. (2015) Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial. Lancet HIV 2:e52-63
Pursnani, Amit; Massaro, Joseph M; D'Agostino Sr, Ralph B et al. (2015) Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events. JAMA 314:134-41
Lehrer-Graiwer, Joshua; Singh, Parmanand; Abdelbaky, Amr et al. (2015) FDG-PET imaging for oxidized LDL in stable atherosclerotic disease: a phase II study of safety, tolerability, and anti-inflammatory activity. JACC Cardiovasc Imaging 8:493-4

Showing the most recent 10 out of 108 publications