This application requests pre-doctoral and post-doctoral funding for Multidisciplinary Training in Translational Cardiovascular Research. The training program in Translational Cardiovascular Research at Columbia University Medical Center is conceived to enhance and ensure the development of cardiovascular scientists who have broadly-based knowledge in the fields of Cardiovascular Cell Biology, Biophysics, Genetics and Genomics, Bio- and Tissue-Engineering and Clinical Sciences. The training will be based within the Clyde and Helen Wu Center for Molecular Cardiology and Department of Physiology and Cellular Biophysics at Columbia University College of Physicians &Surgeons, and the Judith Sulzberger Genome Center which includes an NIH Roadmap Functional Genomics High Throughput screening center. Particular emphasis has been placed on diversity through a Minority Research Fellowship Program for undergraduates in New York City Universities that serves as a pipeline for underserved minorities to train in the cardiovascular training program at Columbia. Members of the Center for Molecular Cardiology include basic and translational researchers whose primary appointments are within the Departments of Medicine, Pharmacology, and Physiology and Cellular Biophysics. The Center and the Department of Physiology have well-established cardiovascular seminar series and journal clubs, joint laboratory meetings, and retreats, that are designed to encourage collaborations and foster excellence in cardiovascular research. A course in basic and translational cardiovascular biology bridges fundamental cardiovascular molecular physiology with translational cardiovascular biology. Trainees will be exposed to a diverse group of faculty, including several at outside institutions and in the pharmaceutical industry who will provided short-term targeted mentoring in specific areas such as genetics, cell imaging, high throughput screening, which would not be possible if they trained in a single laboratory or at one institution. The proposed program will use an interdisciplinary approach with special emphasis on forward thinking science including functional genomics, chemical biology, structural biology, tissue engineering, bioengineering and molecular physiology all in the context of established cardiovascular laboratories headed by some of the world's leading cardiovascular scientists.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Chang, Donald D; Colecraft, Henry M (2015) Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in Ca(V)1.2 channel regulation. J Physiol 593:5075-90
Maksimovic, Srdjan; Nakatani, Masashi; Baba, Yoshichika et al. (2014) Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature 509:617-21
Maksimovic, Srdjan; Baba, Yoshichika; Lumpkin, Ellen A (2013) Neurotransmitters and synaptic components in the Merkel cell-neurite complex, a gentle-touch receptor. Ann N Y Acad Sci 1279:13-21
Yang, Tingting; He, Lin-Ling; Chen, Ming et al. (2013) Bio-inspired voltage-dependent calcium channel blockers. Nat Commun 4:2540
Totary-Jain, Hana; Sanoudou, Despina; Dautriche, Cula N et al. (2012) Rapamycin resistance is linked to defective regulation of Skp2. Cancer Res 72:1836-43
Maidhof, Robert; Tandon, Nina; Lee, Eun Jung et al. (2012) Biomimetic perfusion and electrical stimulation applied in concert improved the assembly of engineered cardiac tissue. J Tissue Eng Regen Med 6:e12-23
Levin, Elena J; Cao, Yu; Enkavi, Giray et al. (2012) Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A 109:11194-9
Pan, Yaping; Weng, Jun; Levin, Elena J et al. (2011) Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain. Proc Natl Acad Sci U S A 108:5885-90
Cao, Yu; Jin, Xiangshu; Levin, Elena J et al. (2011) Crystal structure of a phosphorylation-coupled saccharide transporter. Nature 473:50-4
Li, Gang; Scull, Christopher; Ozcan, Lale et al. (2010) NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol 191:1113-25

Showing the most recent 10 out of 17 publications