The University of Kentucky Training Program for Clinical Scholars in Cardiovascular Science is designed to prepare exceptional clinical scholars to assume leadership positions directing multidisciplinary research in the field of cardiovascular medicine. In the last several years, as a consequence of substantial institutional commitment, we have assembled a vertically-integrated approach of incorporating basic, translational and clinical cardiovascular science in four concentrations: Thrombosis and Inflammation;Atherosclerosis and Aneurysm;Cardiac Hypertrophy and Heart Failure;and Vascular Cell Response to Stress. We propose to leverage our cardiovascular science strengths to provide a unique multidisciplinary training program that horizontally integrates trainees across the disciplines of Medicine, Nursing, and Pharmacy. Our goal is to increase the pipeline of clinical investigators who will bridge the gap between basic science advances and their application to clinical medicine. Specifically, our aims are: 1) To provide a rigorous and solid research education in the basic sciences related to cardiovascular research 2) To prepare new researchers for translational and clinical science in a highly interdisciplinary environment 3) To provide training in the efficient and ethical conduct of high quality laboratory management and science 4) To create an environment that will incubate scholars and mentors with an innovative and nurturing structure of interlaced mentoring teams To accomplish our goal, we have designed the Program to focus on clinicians (MD, PharmD, RN/PhD) who are at the early postdoctoral stage of their careers. The Program will combine an intensive mentored research experience that blends laboratory-based and clinically-based methods with a rigorous curriculum in cardiovascular science. A committee of experienced investigators will enhance the research experience by providing insight and oversight. Scholars will receive supplemental training in """"""""survival skills"""""""" and be , active participants in our cardiovascular community. Upon completion of the program, we anticipate that the trainees will have the experience and capabilities necessary to initiate an independent career as a patient- oriented or translational investigators.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL091812-03
Application #
7835700
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Commarato, Michael
Project Start
2008-06-01
Project End
2013-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
3
Fiscal Year
2010
Total Cost
$242,784
Indirect Cost
Name
University of Kentucky
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Haedtke, Christine; Smith, Marianne; VanBuren, John et al. (2017) The Relationships Among Pain, Depression, and Physical Activity in Patients With Heart Failure. J Cardiovasc Nurs 32:E21-E25
Butt, Muhammad Umer; Buzsaki, Lili A; Smyth, Susan S et al. (2017) Deep Vein Thrombosis Complicated by Spontaneous Iliopsoas Hematoma in Patient with Septic Shock. Am J Case Rep 18:1148-1152
Haedtke, Christine; Smith, Marianne; VanBuren, John et al. (2017) The Characteristics of Pain in Patients Diagnosed with Depression and Heart Failure. Pain Manag Nurs 18:353-362
Sexton, Travis R; Wallace, Eric L; Chen, Amy et al. (2016) Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement. J Thromb Thrombolysis 41:384-93
Pumphrey, Ashley; Yang, Zhengshi; Ye, Shaojing et al. (2016) Advanced cardiac chemical exchange saturation transfer (cardioCEST) MRI for in vivo cell tracking and metabolic imaging. NMR Biomed 29:74-83
Yasuma, Reo; Cicatiello, Valeria; Mizutani, Takeshi et al. (2016) Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal Transduct Target Ther 1:
Bogdanovich, Sasha; Kim, Younghee; Mizutani, Takeshi et al. (2016) Human IgG1 antibodies suppress angiogenesis in a target-independent manner. Signal Transduct Target Ther 1:
Haggerty, Christopher M; Mattingly, Andrea C; Kramer, Sage P et al. (2015) Left ventricular mechanical dysfunction in diet-induced obese mice is exacerbated during inotropic stress: a cine DENSE cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 17:75
Gelfand, Bradley D; Wright, Charles B; Kim, Younghee et al. (2015) Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. Cell Rep 11:1686-93
Yiannikouris, Frederique; Wang, Yu; Shoemaker, Robin et al. (2015) Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice. Hypertension 66:836-42

Showing the most recent 10 out of 39 publications