The University of Kentucky Training Program for Clinical Scholars in Cardiovascular Science (hereafter referred to as """"""""the Program"""""""") prepares clinical scholars to assume leadership positions directing research in the field of cardiovascular medicine. In the last several years, we have leveraged our cardiovascular science strengths to provide a unique multidisciplinary training program that horizontally integrates trainees across the disciplines of Medicine, Nursing, and Pharmacy. With this approach, we have achieved our goal of increasing the pipeline of investigators who bridge the gap between basic science advances and their application to clinical medicine. This has been achieved by providing a highly collaborative training environment that combines strong science with the study of cardiovascular biology and disease in clinical populations. As described in this application, our program features substantial collaborations between faculty mentors, a talented pool of qualified applicants, and solid infrastructure and institutional support. The success of our trainees in the first funding cycle demonstrates our ability to achieve our aims, which are: 1) To provide a rigorous and solid research education in the basic sciences related to cardiovascular research 2) To prepare new researchers for translational and clinical science in a highly interdisciplinary environment 3) To provide training in the efficient and ethical conduct of high quality laboratory management and science 4) To create an environment that will incubate scholars and mentors with an innovative and nurturing structure

Public Health Relevance

The University of Kentucky Clinical Scholars in Cardiovascular Science Training Program prepares fellows to assume positions at the forefront of cardiovascular discovery. By doing so, we have increased the pipeline of physicians and scientists that contribute at the highest levels to advancing the cardiovascular health of the nation.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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University of Kentucky
Internal Medicine/Medicine
Schools of Medicine
United States
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Sexton, Travis R; Wallace, Eric L; Chen, Amy et al. (2016) Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement. J Thromb Thrombolysis 41:384-93
Bogdanovich, Sasha; Kim, Younghee; Mizutani, Takeshi et al. (2016) Human IgG1 antibodies suppress angiogenesis in a target-independent manner. Signal Transduct Target Ther 1:
Pumphrey, Ashley; Yang, Zhengshi; Ye, Shaojing et al. (2016) Advanced cardiac chemical exchange saturation transfer (cardioCEST) MRI for in vivo cell tracking and metabolic imaging. NMR Biomed 29:74-83
Yasuma, Reo; Cicatiello, Valeria; Mizutani, Takeshi et al. (2016) Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal Transduct Target Ther 1:
Abdel-Latif, Ahmed; Heron, Paula M; Morris, Andrew J et al. (2015) Lysophospholipids in coronary artery and chronic ischemic heart disease. Curr Opin Lipidol 26:432-7
Mizutani, Takeshi; Fowler, Benjamin J; Kim, Younghee et al. (2015) Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci 56:7122-9
Mueller, Paul; Ye, Shaojing; Morris, Andrew et al. (2015) Lysophospholipid mediators in the vasculature. Exp Cell Res 333:190-4
Klyachkin, Yuri M; Nagareddy, Prabakara R; Ye, Shaojing et al. (2015) Pharmacological Elevation of Circulating Bioactive Phosphosphingolipids Enhances Myocardial Recovery After Acute Infarction. Stem Cells Transl Med 4:1333-43
Haggerty, Christopher M; Mattingly, Andrea C; Kramer, Sage P et al. (2015) Left ventricular mechanical dysfunction in diet-induced obese mice is exacerbated during inotropic stress: a cine DENSE cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 17:75
Yiannikouris, Frederique; Wang, Yu; Shoemaker, Robin et al. (2015) Deficiency of angiotensinogen in hepatocytes markedly decreases blood pressure in lean and obese male mice. Hypertension 66:836-42

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