This T-32 Training application is to competitively renew the current T32 pulmonary training program, anchored within the Indiana University School of Medicine, the only medical school in the state of Indiana. The proposed program builds on the success of the current training award, being multidisciplinary, highly collaborative, and including established investigators and highly qualified and dedicated mentors. We will continue to expose trainees to classical elements of basic and clinical-translational research, to which we incorporated novel technologies and a robust component of regenerative medicine, building on our local strengths. New in this application is a partnership with Pediatric Pulmonology at IU, fueled by the realization that adult lung diseases start in childhood or even prenatally, and by the strong history of cross training our fellows in research. Given the success and growth of our program, we are also proposing an increase in the number of trainees, adding one predoctoral and one postdoctoral spot to the three postdoctoral positions from the current program. The addition of one predoctoral position will also allow us to more efficiently to recruit future leaders of pulmonary and critical care medicine at an early stage. Finally, we propose to offer to interested postdocs a track for training in life science entrepreneurship, as an alternatie but yet important science career track. The ultimate goal is for us to train investigators that wil accelerate the advancements in lung research and close the gaps in knowledge that prevented for so many decades the development of phenotypic characterization, effective preventive intervention, and disease-modifying or even curative druts for most patients with lung disease. We maintain the strong commitment to training underrepresented minority talent and by a strong oversight from leaders in the field.

Public Health Relevance

We propose a training plan for one predoctoral student, two pulmonary physicians and two PhD scientists to become outstanding researchers or entrepreneurs in both Adult and Pediatric Pulmonary and Critical Care Medicine, which studies lung diseases such as COPD/emphysema, pneumonia, asthma, acute lung injury, lung transplant, pulmonary hypertension, as well as cystic fibrosis, BPD, and early origins of adult lung disease. There is a high requirement to train experts who will discover new management tools needed for lung diseases which contribute to a high mortality in the US and our program is designed to address this need.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Kalantari, Roya
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Indiana University-Purdue University at Indianapolis
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United States
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Khan, Sikandar H; Kitsis, Michelle; Golovyan, Dmitriy et al. (2018) Effects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature. Heart Lung 47:489-496
Khan, Sikandar; Biju, Ashok; Wang, Sophia et al. (2018) Mobile critical care recovery program (m-CCRP) for acute respiratory failure survivors: study protocol for a randomized controlled trial. Trials 19:94
Golovyan, Dmitriy M; Khan, Sikandar H; Wang, Sophia et al. (2018) What should I address at follow-up of patients who survive critical illness? Cleve Clin J Med 85:523-526
Ni, Kevin; Gill, Amar; Tseng, Victor et al. (2018) Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res 19:107
Wang, Sophia; Hammes, Jessica; Khan, Sikandar et al. (2018) Improving Recovery and Outcomes Every Day after the ICU (IMPROVE): study protocol for a randomized controlled trial. Trials 19:196
Khan, Sikandar H; Devnani, Rohit; LaPradd, Michelle et al. (2018) Age of transfused red blood cells and health outcomes in two surgical cohorts. Heart Lung :
Frump, Andrea L; Selej, Mona; Wood, Jordan A et al. (2018) Hypoxia Upregulates Estrogen Receptor ? in Pulmonary Artery Endothelial Cells in a HIF-1?-Dependent Manner. Am J Respir Cell Mol Biol 59:114-126
Khan, Sikandar H; Wang, Sophia; Harrawood, Amanda et al. (2017) Decreasing Delirium through Music (DDM) in critically ill, mechanically ventilated patients in the intensive care unit: study protocol for a pilot randomized controlled trial. Trials 18:574
Brown, Mary Beth; Neves, Evandro; Long, Gary et al. (2017) High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol 312:R197-R210
Wang, Sophia; Mosher, Chris; Perkins, Anthony J et al. (2017) Post-Intensive Care Unit Psychiatric Comorbidity and Quality of Life. J Hosp Med 12:831-835

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