The number of promising young biomedical scientists focused on lung disease is declining to a critically low level, resulting in a pressing need to tran a new generation of researchers focused on elucidating disease mechanisms. Acute and chronic lung diseases are major causes of morbidity and mortality throughout the world. For many of these diseases, the fundamental pathobiology is not well understood and effective disease-modifying treatments are not available. This training program named "Interdisciplinary Training Program in Lung Research" focuses on training researchers in basic mechanisms of lung disease and is committed to equipping young investigators with the skill set necessary to develop into successful researchers and academic leaders. The Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University and the Vanderbilt Center for Lung Research (VCLR) have a long, successful history in developing well-trained researchers who have the vision and the skills with which to embark on successful research careers. This program is housed in the VCLR, which was developed to coordinate and enhance collaborative interdisciplinary research and training. Dr. Timothy Blackwell (director of the VCLR) serves as program director. The program is designed to support post-doctoral trainees (both M.D. and Ph.D.) who show exceptional aptitude for successfully pursuing an academic research career. Trainees concentrate on one of several disease focused areas of existing expertise in the VCLR: acute lung inflammation/injury, asthma, pulmonary fibrosis, pulmonary hypertension, or lung carcinogenesis. A customized mentoring team is formed for each trainee, consisting of a mentor with nationally recognized expertise in the area and a research advisory committee to provide additional guidance, mentoring, and feedback. The trainee's experience is enhanced by interactions with other investigators and trainees in existing lung disease-focused research programs in the VCLR, an extensive program of seminars and conferences, and coursework tailored to meet the needs of each trainee. As a result, each trainee develops an understanding of the translational paradigm in his/her area of research and attains the academic skills necessary to become a future leader in the field of lung research.

Public Health Relevance

It has never been more important than now to support the development of a cadre of biomedical research scientists and physician-scientists who collaborate to make rapid progress in determining mechanisms of lung disease and developing new therapies. This interdisciplinary program in lung research prepares future independent investigators for the unique challenges associated with advancing science and public health in pulmonary and critical care medicine.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHL1-CSR-F (F2))
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Colombini-Hatch, Sandra
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Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
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Dulek, Daniel E; Newcomb, Dawn C; Toki, Shinji et al. (2014) STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol 88:9655-72
Dulek, Daniel E; Newcomb, Dawn C; Goleniewska, Kasia et al. (2014) Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun 82:3723-39
Hemnes, Anna R; Brittain, Evan L; Trammell, Aaron W et al. (2014) Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med 189:325-34
Kropski, Jonathan A; Mitchell, Daphne B; Markin, Cheryl et al. (2014) A novel dyskerin (DKC1) mutation is associated with familial interstitial pneumonia. Chest 146:e1-7
Kropski, Jonathan A; Lawson, William E; Young, Lisa R et al. (2013) Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis. Dis Model Mech 6:9-17
Richmond, Bradley W; Ploetze, Kristen; Isom, Joan et al. (2013) Sarcoidosis Th17 cells are ESAT-6 antigen specific but demonstrate reduced IFN-ýý expression. J Clin Immunol 33:446-55
Sevin, Carla M; Newcomb, Dawn C; Toki, Shinji et al. (2013) Deficiency of gp91phox inhibits allergic airway inflammation. Am J Respir Cell Mol Biol 49:396-402
Reed, N P; Henderson, M A; Oltz, E M et al. (2013) Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Genes Immun 14:7-12
Drake, Wonder P; Oswald-Richter, Kyra; Richmond, Bradley W et al. (2013) Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study. JAMA Dermatol 149:1040-9
Damo, Steven M; Kehl-Fie, Thomas E; Sugitani, Norie et al. (2013) Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens. Proc Natl Acad Sci U S A 110:3841-6

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