This is an application for continuation of the postdoctoral training program in lung biology and disease at the University of Texas Southwestern Medical Center. Training will be directed at the postdoctoral level, and the research training will be for two years in addition to any associated clinical training. The proposal is born out of a collaborative effort between divisions within the Pediatric and Internal Medicine departments involved in lung research at this institute, and is thus interdepartmental at its core. Our training faculty consist of experienced investigators representing 16 different clinical and basic science departments and centers, forming a solid, diverse training force, organized into four thematic tracks: 1) Pulmonary vascular disease;2) Interstitial lung diseases;3) Lung epithelial cell and differentiation disorders;and 4) Immunity/Inflammation/Sepsis. Besides mentor-based teaching, trainees will receive a comprehensive track- and project-specific didactic curriculum. Both clinical and basic science trainees will be guided by an individualized advisory committee that has both basic and clinical science mentors, to broaden the trainee's perspective and facilitate bench to bedside thinking. Emphasis will be placed on maintenance of project focus, creative experimental design, state of the art technology, and careful early career guidance.

Public Health Relevance

Lung diseases continue to account for most of the leading causes of death in the United States. Despite the need for further lung research targeted broadly at basic and clinical levels, there is a national shortage of clinically-directed scientists. The goal of the UT Southwestern Lung Biology and Disease Training program is to provide in-depth research training for postdoctoral fellows involved in adult and pediatric lung disease research, to invest in the future of lung-related research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Colombini-Hatch, Sandra
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University of Texas Sw Medical Center Dallas
Internal Medicine/Medicine
Schools of Medicine
United States
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Chambliss, Ken L; Barrera, Jose; Umetani, Michihisa et al. (2016) Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. Endocrinology 157:3731-3741
Morrow, K Adam; Ochoa, Cristhiaan D; Balczon, Ron et al. (2016) Pseudomonas aeruginosa exoenzymes U and Y induce a transmissible endothelial proteinopathy. Am J Physiol Lung Cell Mol Physiol 310:L337-53
Cho, Geoffrey W; Altamirano, Francisco; Hill, Joseph A (2016) Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death. Biochim Biophys Acta 1862:763-77
Ulrich, Victoria; Gelber, Shari E; Vukelic, Milena et al. (2016) ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice. Arthritis Rheumatol 68:730-9
Regan, Erin; Sibley, Robert C; Cenik, Bercin Kutluk et al. (2016) Identification of Gene Expression Differences between Lymphangiogenic and Non-Lymphangiogenic Non-Small Cell Lung Cancer Cell Lines. PLoS One 11:e0150963
Philley, Julie V; Wallace Jr, Richard J; Benwill, Jeana L et al. (2015) Preliminary Results of Bedaquiline as Salvage Therapy for Patients With Nontuberculous Mycobacterial Lung Disease. Chest 148:499-506
Morrow, K A; Seifert, R; Kaever, V et al. (2015) Heterogeneity of pulmonary endothelial cyclic nucleotide response to Pseudomonas aeruginosa ExoY infection. Am J Physiol Lung Cell Mol Physiol 309:L1199-207
Philley, Julie V; Griffith, David E (2015) Treatment of slowly growing mycobacteria. Clin Chest Med 36:79-90
Xin, Wenkuan; Feinstein, Wei P; Britain, Andrea L et al. (2015) Estimating the magnitude of near-membrane PDE4 activity in living cells. Am J Physiol Cell Physiol 309:C415-24
Tokman, Sofya; Singer, Jonathan P; Devine, Megan S et al. (2015) Clinical outcomes of lung transplant recipients with telomerase mutations. J Heart Lung Transplant 34:1318-24

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