There has been a long history of cardiovascular research at the University of Mississippi Medical Center (UMMC). Much of this research has been conducted in the Department of Physiology where their efforts are directed toward developing a quantitative and integrated analysis of the cardiovascular and renal systems. In addition both basic and clinical research on hypertension and cardio-renal diseases at UMMC have expanded in various departments and programs such as Pharmacology, Biochemistry, Neurosciences, Medicine, Endocrinology, and Obstetrics and Gynecology. UMMC also serves as the Examination Center for the Jackson Heart Study that has a major focus on cardiovascular disease in African Americans. UMMC has also been a participant is several major clinical trials such as ALLHAT. Thus, UMMC has a diversity of basic, clinical, and population research programs in cardiovascular diseases. The main objective of the multidisciplinary Hypertension and Cardiorenal Diseases Research (HCDR) Training Program is to recruit, train, and mentor pre-doctoral and postdoctoral students in hypertension and cardiovascular and renal research so that they become the next generation of researchers in this field. To achieve this goal the Center for Excellence in Cardiovascular-Renal Research (CECR) at UMMC will provide a stimulating and productive mentoring environment for pre-doctoral and postdoctoral students. The HCDR Training Program not only capitalizes on the expertise of a strong group of basic science and clinical investigators in the field of cardiovascular and renal research at UMMC but also the resources provided by these established laboratories and the CECR core facilities.
The specific aims of this training grant proposal are as follows: 1. To train pre-doctoral students (3) in a multi-disciplinary approach in course work and research opportunities in hypertension and cardiovascular-renal disease research. 2. To provide postdoctoral students (5) multi-disciplinary training and mentoring in hypertension and cardiovascular-renal disease research 3. To recruit and train minority pre-doctoral and postdoctoral students in hypertension and cardiovascular- renal diseases research. Funding of the HCDR training program at UMMC would increase the quality and quantity of trainees in this multi-disciplinary program and greatly enhance our ability to train the next generation of biomedical scientists in hypertension and cardio-renal diseases research.
Hypertension has long been recognized as a major risk factor for cardiovascular diseases, including coronary artery disease, heart failure and stroke, and for ESRD. In the southeastern United States, and especially in Mississippi, cardiovascular and renal diseases occur much more frequently than in the rest of the country. The objective of the multidisciplinary Hypertension and Cardiorenal Diseases Research (HCDR) Training Program is to recruit, train, and mentor pre-doctoral and postdoctoral students in cardiovascular and renal research so that they become the next generation of researchers in this field.
|Xiang, Lusha; Lu, Silu; Mittwede, Peter N et al. (2014) Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma. Am J Physiol Heart Circ Physiol 306:H684-9|
|Hosick, P A; AlAmodi, A A; Storm, M V et al. (2014) Chronic carbon monoxide treatment attenuates development of obesity and remodels adipocytes in mice fed a high-fat diet. Int J Obes (Lond) 38:132-9|
|Wallace, Kedra; Cornelius, Denise C; Scott, Jeremy et al. (2014) CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia. Hypertension 64:1151-8|
|Mathis, Keisa W; Broome, Hanna J; Ryan, Michael J (2014) Autoimmunity: an underlying factor in the pathogenesis of hypertension. Curr Hypertens Rep 16:424|
|Oguchi, Hideyo; Sasamura, Hiroyuki; Shinoda, Kazunobu et al. (2014) Renal arteriolar injury by salt intake contributes to salt memory for the development of hypertension. Hypertension 64:784-91|
|Wallace, Kedra; Morris, Rachael; Kyle, Patrick B et al. (2014) Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome. Hypertens Pregnancy 33:41-54|
|DeCoux, Ashley; Lindsey, Merry L; Villarreal, Francisco et al. (2014) Myocardial matrix metalloproteinase-2: inside out and upside down. J Mol Cell Cardiol 77:64-72|
|Morris Jr, Michael W; Allukian 3rd, Myron; Herdrich, Benjamin J et al. (2014) Modulation of the inflammatory response by increasing fetal wound size or interleukin-10 overexpression determines wound phenotype and scar formation. Wound Repair Regen 22:406-14|
|Amaral, Lorena M; Kiprono, Luissa; Cornelius, Denise C et al. (2014) Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy. Am J Obstet Gynecol 211:158.e1-6|
|Mathis, Keisa W; Wallace, Kedra; Flynn, Elizabeth R et al. (2014) Preventing autoimmunity protects against the development of hypertension and renal injury. Hypertension 64:792-800|
Showing the most recent 10 out of 26 publications