The Cedars-Sinai Heart Institute (CSHI) is applying for the first competitive renewal of its Advanced Heart Disease Research Training Program. The objective of this Institutional Training Program is to build on our initial success (66% success rate for K awards in our first graduating class) to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide postdoctoral fellows with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the- art investigations in the laboratory. Our training program's areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, Community Health, Implementation Science, Precision Medicine and Genetics. The Training Program takes full advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.
The Cedars-Sinai Heart Institute is renewing its Institutional Training Grant for its Advanced Heart Disease Research Training Program. The objective of the program is to provide outstanding team-mentored training in basic biomedical and translational research to both PhDs and MD-scientists in order to provide them with the necessary skills to develop independent and productive academic careers in cardiovascular science. These future leaders of medicine will be well-equipped to develop new, more effective treatments for diseases of the heart and blood vessels such as heart attack, heart failure, high blood pressure and sudden death.
|Cho, Jae Hyung; Kilfoil, Peter J; Zhang, Rui et al. (2018) Reverse electrical remodeling in rats with heart failure and preserved ejection fraction. JCI Insight 3:|
|Ebinger, Joseph E; Strauss, Craig E; Garberich, Ross R et al. (2018) Value-Based ST-Segment-Elevation Myocardial Infarction Care Using Risk-Guided Triage and Early Discharge. Circ Cardiovasc Qual Outcomes 11:e004553|
|Shaw, Jaime L; Yang, Qi; Zhou, Zhengwei et al. (2018) Free-breathing, non-ECG, continuous myocardial T1 mapping with cardiovascular magnetic resonance Multitasking. Magn Reson Med :|
|Christodoulou, Anthony G; Shaw, Jaime L; Nguyen, Christopher et al. (2018) Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging. Nat Biomed Eng 2:215-226|
|Cho, Jae Hyung; Zhang, Rui; Aynaszyan, Stephan et al. (2018) Ventricular Arrhythmias Underlie Sudden Death in Rats With Heart Failure and Preserved Ejection Fraction. Circ Arrhythm Electrophysiol 11:e006452|
|Ma, Sen; Nguyen, Christopher T; Christodoulou, Anthony G et al. (2018) Accelerated Cardiac Diffusion Tensor Imaging Using Joint Low-Rank and Sparsity Constraints. IEEE Trans Biomed Eng 65:2219-2230|
|Elboudwarej, Omeed; Wei, Janet; Darouian, Navid et al. (2018) Maladaptive left ventricular remodeling in women: An analysis from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction study. Int J Cardiol 268:230-235|
|Sin, Jon; McIntyre, Laura; Stotland, Aleksandr et al. (2017) Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes. J Virol 91:|
|Gallet, Romain; Dawkins, James; Valle, Jackelyn et al. (2017) Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. Eur Heart J 38:201-211|
|Wei, Janet; Mehta, Puja K; Grey, Elizabeth et al. (2017) Sex-based differences in quality of care and outcomes in a health system using a standardized STEMI protocol. Am Heart J 191:30-36|
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